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| 1 | Diabetic retinopathy and age-related macular degeneration: a survey of pharmacoutilization and cost in Calabria, Italy显示文摘The aged population is constantly growing, thus fostering an increase in age-dependent diseases. Among these, diabetic retinopathy (DR) along with age-related macular degeneration entails progressive vision loss. Since such conditions are associated with the proliferation of novel vessels, their pharmacotherapeutic management consists of the intravitreal injection of anti-vascular endothelial growth factor drugs, able to hinder the driving of vascular proliferation prompted by vascular endothelial growth factor. The humanized anti-vascular endothelial growth factor monoclonal antibody ranibizumab provided evidence for efficacy in several trials, hence earning approval by the US Food and Drug Administration for therapeutic use in all the stages of DR. Due to the lack of epidemiologic and pharmacoeconomic evaluation in the local Calabria Region context, the present retrospective observational study focused on prevalence of DR and age-related macular degeneration, treatment and cost of therapy with ranibizumab in 870 patients arriving to clinical observation at the 'Mater Domini” University Hospital in Calabria, Italy from January 2014 to June 2017. Data were extracted from the database of ophthalmology ward and subjected to statistical analysis. The results suggest that the most frequent retinal diseases are age-related macular degeneration and DR and that the use of ranibizumab has been decreasing over the 4-year study period together with the associated cost per patient which was similar for both disorders. Therefore, appropriateness of treatment with drugs other than ranibizumab needs to be assessed in this setting and deep monitoring of pharmacologic treatment for retinal diseases is necessary to prevent or delay visual acuity decrease and complete vision loss. Study procedures were performed in accordance with the 'Mater Domini” University Hospital ethical standards of the responsible committee on human experimentation. | Damiana Scuteri Ada Vero Mariacristina Zito Maria Diana Naturale Giacinto Bagetta Carlo Nucci Paolo Tonin Maria Tiziana Corasaniti | 2019 | Neural Regeneration Research2019，14，8： | 3 |
| 2 | 显示文摘 | da-Costa JL Tonin FG Zanolli LA | 2009 | Electrophoresis2009，30，12： | 1 |
| 3 | Satisfaction with care in post-stroke patients undergoing a telerehabilitation programme at home 显示文摘 | Piton L Turolla A Tonin P | 2008 | J Telemed Telecare2008，14，5： | 1 |
| 4 | AZT-induced mitochondrial myopathy显示文摘 | Tomelleri G Tonin P Spadaro M | 1992 | Ital J Neurol Sci1992，13，9： | 1 |
| 5 | Study on the conversion of wool keratin by steam explosion 显示文摘 | Claudio Tonin Marina Zoccola Annalisa Aluigi | 2006 | Biomacromolecules2006，，7： | 1 |
| 6 | The limited spectrum of pathogenic BRCA1 and BRCA2mutation in the French Canadian breast and breast-ovarian cancer families,a founder population of Quebec,Canada显示文摘 | | 2006 | Bull Cancer2006，93，9： | 1 |
| 7 | Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy显示文摘 | DAM M TONIN P DE BONI A | 1996 | Stroke1996，27，7： | 1 |
| 8 | The augmented-feedback rehabilitation technique facilitates the arm motor recovery in patients after a recent stroke 显示文摘 | Piron L Tonin P Atzori AM | 2003 | Stud Health Technol Inform2003，94，： | 1 |
| 9 | Optimizing the separation of food dyes by capillary electrophoresis显示文摘 | Jager A V Tonin F G Tavares M F M | 2005 | J Sep Sci2005，28，910： | 1 |
| 10 | Assessment of arbuscular mycorrhizal fungi diversity in the rhizosphere of Viola calaminaria and effect of these fungi on heavy metal uptake by clover显示文摘 | C. Tonin P. Vandenkoornhuyse E. J. Joner J. Straczek C. Leyval | 2001 | Mycorrhiza2001，，4： | 1 |
| 11 | En- demic carbapenem-resistant Pseudomonas aeruginosa with acquired metallo-beta-lactamase determinants in European hospital显示文摘 | Lagatolla C Tonin EA Monti-Bragadin C | 2004 | Emerg Infect Dis2004，10，3： | 1 |
| 12 | Topical tacrolimus in the treatment of lichen planus in a child显示文摘 | Fortina A B Giulioni E Tonin E | 2008 | Pediatr Dermatol2008，25，5： | 1 |
| 13 | Multineuropathy in a patient with HBV infection, polyarteritis nodosa and celiac disease显示文摘 | Giovanna Squintani Sergio Ferrari Paola Caramaschi Tiziana Cavallaro Nicola Refatti Nicola Rizzuto Paola Tonin | 2009 | Rheumatology International2009，，5： | 1 |
| 14 | Endemic carbapenem-resistant Pseudomonas aeruginosa with acquired metallo-beta-lactamase determinants in European hospital显示文摘 | Lagatolla C Tonin EA Monti-Bragadin C | 2004 | Emergency Infect Disease2004，10，3： | 1 |
| 15 | HPLC- DAD-ESI/MS identification and quantifi-cation of phenolic compounds in iiex paraguariensis beverages and on-line e- valuation of ir/div-idual antioxidant activity显示文摘 | Peres R G Tonin F G Tavares M F M | 2013 | Molecules2013，18，4： | 1 |
| 16 | Reducing the risk of dislocationafter total hip arthroplasty : the effect of orientation of the acetabularcomponent显示文摘 | Biedermann R Tonin A Krismer M | 2005 | J Bone Joint Surg Br2005，87，6： | 1 |
| 17 | Reducing the risk of dislocation after total hip arthroplasty:the effect of orientation of the acetabular component 显示文摘 | Bierdermann R Tonin A Krismer M | 2005 | J Bone Joint Surg2005，87，6： | 1 |
| 18 | Neuropathology of mitochondrial diseases显示文摘 | Filosto M Tomelleri G Tonin P | 2007 | Bioscience Reports2007，27，13： | 1 |
| 19 | Motor tele-rehabilitation in post-stroke patients显示文摘 | Piron L Tonin P Trivello E | 2004 | Med Inform Internet Med2004，29，2： | 1 |
| 20 | Improving electrical performances of wool textiles:synthesis of conducting polypyrrole on the fiber surface显示文摘 | VARESANO A TONIN C | | 0，，12： | 1 |
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