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| 1 | Epidemiology and Diagnosis of H elicobacter pylori Infection显示文摘 | Ante Tonkic Marija Tonkic Philippe Lehours Francis Mégraud | 2012 | Helicobacter2012，，： | 6 |
| 2 | Inactive matrix Gla protein is elevated in patients with inflammatory bowel disease显示文摘BACKGROUND Matrix Gla protein(MGP)is a vitamin K dependent peptide which has an established role in suppression of vascular calcification.Recent studies have pointed to a possible link between immunomodulatory effect of MGP and inflammatory bowel disease(IBD).AIM To compare plasma levels of dephosphorylated and uncarboxylated MGP(dpucMGP)between IBD patients and controls.METHODS This cross-sectional study was conducted on 70 patients with IBD(30 patients with ulcerative colitis and 40 patients with Crohn’s disease)and 60 age and gender matching healthy controls.Plasma dp-ucMGP levels were analyzed from blood samples by CLIA method using IDS-iSYS InaKtif MGP(Immunodiagnostic Systems,Frankfurt,Germany)according to the manufacturer's instructions.fecal calprotectin(FC)levels were determined from stool samples by turbidimetric immunoassay method using Bühlmann fecal calprotectin turbo assay(Bühlmann Laboratories Aktiengesellschaft,Schonenbuch,Switzerland).Other parameters were analyzed according to the standard laboratory procedures.RESULTS Plasma levels of dp-ucMGP were significantly higher in patients with IBD compared to the healthy control group(629.83±124.20 pmol/mL vs 546.7±122.09 pmol/mL,P<0.001),and there was no significant difference between patients with Crohn’s disease and patients with ulcerative colitis(640.02±131.88 pmol/mL vs 616.23±113.92 pmol/mL,P=0.432).Furthermore,a significant positive correlation of plasma dp-ucMGP levels was found with both FC levels(r=0.396,P<0.001)and high sensitivity C-reactive protein(hsCRP)levels(r=0.477,P<0.001).Moreover,in the total study population a significant positive correlation was found between dp-ucMGP with age(r=0.210,P=0.016)and waist circumference(r=0.264,P=0.002).Multiple linear regression analysis showed that dp-ucMGP levels retained significant association with FC(β±SE,0.06±0.02,P=0.003).CONCLUSION Study results support experimental data of MGP immunomodulatory IBD effect and indicate potential involvement in the pathophysiology of the disease,and possibly extraintestinal manifestations. | Darko Brnic Dinko Martinovic Piero Marin Zivkovic Daria Tokic Marino Vilovic Doris Rusic Ivana Tadin Hadjina Christian Libers Sandro Glumac Daniela Supe-Domic Ante Tonkic Josko Bozic | 2020 | World Journal of Gastroenterology2020，26，32： | 5 |
| 3 | 十五肽BPC157减弱慢性苯丙胺诱导的行为障碍(英文)显示文摘AIM: To investigate the effect of pentadecapeptide BPC 157 on chronic exposure to amphetamine in rats, particularly the changes commonly referred in chronic amphetamine studies as tolerance ( lesser grade of stereotyped behavior, without increased excitability) and reverse tolerance (ie, prominent stereotyped behavior and heightened startle response upon late amphetamine challenges). METHODS: After initial application (initial single dose-regimen), amphetamine (10 mg/kg, ip) was given once daily till d 5 ( continuous administration-regimen), and thereafter on d 8, 16, and 46 (intermittent administration regimen). For stereotyped behavior and heightened startle response the observation period was 120 min after amphetamine application, and each animal was observed for 10 s in 5 min intervals. Pentadecapeptide BPC 157 (10 μg/kg or 10 ng/kg, ip) or saline (5.0 mL/kg, ip) were given only at the beginning of the experiment, simultaneously with the initial dose of amphetamine. RESULTS: In relation to | Predrag SIKIRIC, Nikola JELOVAC, Andjelka JELOVAC-GJELDUM, Goran DODIG, Mario STARESINIC, Tornislav ANIC, Ivan ZORICIC, Davor RAK, Darko PEROVIC, Gorana ARALICA, Gojko BULJAT, Ingrid PRKACEV, Martina LOVRIC-BENCIC, Jadranka SEPAROVIC, Sven SEIWERTH, Rudolf RUCMAN, Marijan PETEK, Branko TURKOVIC, Tihomil ZIGER, AJenka BOBAN-BLAGAIC, Vlado BEDEKOVIC, Ante TONKIC, Slaven BABIC ( Department of Pharmacology, Medical Faculty University of Zagreb, Croatia) | 2002 | Acta Pharmacologica Sinica2002，23，5： | 2 |
| 4 | Side effects of ropinirole in patients with idiopathic Parkinson's disease 显示文摘 | Titlic M Tonkic A Jukic I | 2008 | Bratisl Lek Listy2008，109，： | 1 |
| 5 | Tinnitus caused by vertebrobasilar dolichoectasia显示文摘 | Titlic M Tonkic A Jukic I | 2007 | Bratisl Lek Listy2007，108，1011： | 1 |
| 6 | Clinical manifestation of ver- tebrobasilar doliechoectasia显示文摘 | Titlic M Tonkic A Jukie I | 2008 | Bratlslleklisty2008，109，6： | 1 |
| 7 | First report of molecular characterization of carbapenem-resistant Acinetobacter baumannii in different intensive care units in university hospital split,Croatia 显示文摘 | Barisic GB Bedenic B Tonkic M | | J Chemotherapy0，19，4： | 1 |
| 8 | Lamotrigine in the treatment of pain syndromes and neuropathic pain显示文摘 | Titlic M Jukic I Tonkic A | 2008 | Bratisl Lek Listy2008，109，9： | 1 |
| 9 | Clinical manifestations of verte- brobasilar doliehoectasia 显示文摘 | Titlic M Tonkic A Jukie I | 2008 | Bratlsl Lek Listy2008，109，6： | 1 |
| 10 | First report of molecular characterization of carbapenem-resistant Acinetobacter baumannii in different intensive care units in university hospital split,Croatia显示文摘 | Barisic GB Bedenic B Tonkic M | 2007 | J Chemotherapy2007，19，4： | 1 |
| 11 | Cerebral venous sinus thrombosis as a recurrent thrombotic event in a patient with heterozygous prothrombin G20210A genotype after discontinuation of oral anticoagulation therapy:how long should we treat these patients with warfarin显示文摘 | Jukic I Titlic M Tonkic A | 2007 | J Thromb Thrombolysis2007，24，1： | 1 |
| 12 | Prevalence and antimicrobial resistance of extended-spectrum beta-lactamases-producing Escherichia coil and Klebsiella pneumonise strains isolated in a university hospital in Split,Croatia显示文摘 | Tonkic M Goic-Barisic I Punda-Polic V | 2005 | Int Microbiol2005，8，2： | 1 |
| 13 | Clinical manifestations of verte- brobasilar dolichoectasia显示文摘 | Titlic M Tonkic A Jukic I | 2008 | Bratisl Lek Listy2008，109，11： | 1 |
| 14 | Interleukins IL-33 and IL-17 IIL-17 A in patients with ulcerative colitis显示文摘 | AjdukovicJ Tonkic A Salamunic I | 2010 | Hepatogastroenterology2010，57，104： | 1 |
| 15 | Use of lamotrigine in glosso-pharyneal neuralgia:a case report显示文摘 | Titlic M Jukick I Tonkic A | 2006 | Headache2006，46，： | 1 |
| 16 | Epidemiology and diagnosis of Helicobacter pylori infection显示文摘 | Tonkic A Tonkic M Lehours P graud F | 2012 | Helicobacter2012，，： | 1 |
| 17 | Clinical manifestations of verte-brobasilar dolichoectasia显示文摘 | Titlic M Tonkic A Jukic I | 2008 | Bratisl Lek Listy2008，109，： | 1 |
| 18 | Prevalence and antimicrobial resistance of extended-spectrum beta-lactamases-producing Escherichia coli and Klebsiella pneumoniae strains isolated in a university hospital in Split,Croatia显示文摘 | Tonkic M Goic-Barisic I Punda-Polic V | 2005 | Int Microbiol2005，8，2： | 1 |
| 19 | Clinical manifestations of vertebrobasilar dolichoectasia显示文摘 | Titlic M Tonkic A Jukic I | 2008 | Bratisl Lek Listy2008，109，11： | 1 |
| 20 | Clinical manifestations of vertebrobasilar dolichoectasia显示文摘 | Titlic M Tonkic A Jukic I | 2008 | Bratisl Lek Listy2008，109，： | 1 |
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