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| 1 | Efficacy and safety of Amla(Phyllanthus emblica L.) in non-erosive reflux disease:a double-blind,randomized,placebo-controlled clinical trial显示文摘Background: Gastroesophageal reflux disease(GERD) is one of the most common gastrointestinal complaints. GERD, caused by the reflux of stomach contents into the esophagus, leads to troublesome symptoms such as heartburn and regurgitation. It is classified into two types: erosive esophagitis,characterized by visible esophageal mucosa erosion in endoscopy, and non-erosive reflux disease(NERD). GERD is a chronic and recurrent disease that impairs the quality of life and imposes socioeconomic and therapeutic burdens to both patients and society.Objective: Due to the failure of the conventional treatments for GERD and to the traditional use of Amla(Phyllanthus emblica L.), in addition to beneficial effects shown in recent studies, we evaluated the safety and efficacy of Amla tablet for improvement of symptoms of patients with NERD.Design, setting, participants and interventions: We designed a double-arm, randomized, double-blind,placebo-controlled clinical trial. Sixty-eight patients who had classic symptoms of GERD(heartburn,regurgitation and epigastralgia) for at least three months before the start of the trial were randomized in two parallel groups. Patients in the Amla group received two 500 mg Amla tablets twice a day, after meals,for 4 weeks. In the control group, patients received placebo tablets similar to the Amla prescription.Main outcome measures: The patients were visited at baseline, and at the end of the 2 nd and 4 th weeks of intervention; their symptoms were measured on a frequency and severity scale for the symptoms of NERD,according to the quality of life in reflux-associated disease questionnaire.Results: Frequencies of heartburn and regurgitation in both groups of the study were significantly reduced after intervention(P < 0.001). Repeated measures logistic regression analysis showed that, in the Amla group, there was a more significant reduction in regurgitation frequency, heartburn frequency, regurgitation severity and heartburn severity during the study period, compared with the placebo group(P < 0.001).Conclusion: This randomized double-blind, placebo-controlled clinical trial demonstrated that Amla could reduce frequencies of heartburn and regurgitation and improve heartburn and regurgitation severity in patients with NERD. | Shahnaz Karkon Varnosfaderani Fataneh Hashem-Dabaghian Gholamreza Amin Mahbubeh Bozorgi Ghazaleh Heydarirad Esmaeil Nazem Mohsen Nasiri Toosi Seyed Hamdollah Mosavat | 2018 | Journal of Integrative Medicine2018，16，2： | 7 |
| 2 | Comparison of ultrasonography and radiography in diagnosis of rib fractures显示文摘肋骨破裂是源于钝胸损伤的最普通的骨胳的胸的损害。肋骨破裂的一半没在精确物理评估和拍之上被检测。最近, ultrasonography (USG ) 被调查了检测肋骨破裂。但是基于文学, USG 的实用性广泛地变化。这研究被进行与这代表性的研究,有次要的钝胸损伤的连续病人和怀疑的肋骨折断在位于马什哈德伊朗的阿訇 Reza 医院里介绍的 radiography.MethodsIn 比较在可能的肋骨破裂的察觉调查 USG 的角色,被 USG 和X光线照相术在2013年4月和2013年10月之间估计。X 光线照相术在胸设计和倾斜的肋骨看法在损伤的区域上集中了的 posteroanterior (PA ) 被执行。在拿 USG 和 X 光线照相术花的时间持续时间被记录。破裂的流行和地点由 USG 表明病人们被估计, X 光线照相术是怀疑的 compared.ResultsSixty 一个。到女比率的男性与一个平均数是 2.4:1 (43 个男人和 18 个女人)? 潲楳? | Elham Pishbin Koorosh Ahmadi Molood Foogardi Maryam Salehi Farrokh Seilanian Toosi Vafa Rahimi-Movaghar | 2017 | Chinese Journal of Traumatology2017，20，4： | 5 |
| 3 | Molecular epidemiology of hepatitis C virus among injection drug users in Iran: a slight change in prevalence of HCV genotypes over time显示文摘 | Katayoun Samimi-Rad Mohsen Nasiri Toosi Ali Masoudi-nejad Ali Najafi Ramin Rahimnia Fatemeh Asgari Alireza Namazi Shabestari Gholamreza Hassanpour Seyed-Moayed Alavian Freshteh Asgari | 2012 | Archives of Virology2012，，10： | 2 |
| 4 | Does Percutaneous Kyphoplasty Have Better Functional Outcome Than Vertebroplasty in Single Level Osteoporotic Compression Fractures? A Comparative Prospective Study显示文摘 | F. Omidi-Kashani F. Samini E. G. Hasankhani A. R. Kachooei K. Z. Toosi F. Golhasani-Keshtan Jun Iwamoto | 2013 | Journal of Osteoporosis2013，，： | 2 |
| 5 | Biochar Adsorbed Ammonia Is Bioavailable显示文摘 | Arezoo Taghizadeh -Toosi Tim J Clough Robert R Sherlock | 2012 | Plant and Soil2012，350，2： | 1 |
| 6 | Erythroderma:a clinical study of 97 eases显示文摘 | Akhyani M Ghodsi ZS Toosi S | | 0，，： | 1 |
| 7 | Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke显示文摘 | Werring DJ Toosy AT Clark CA | 2000 | J Neurol Neurosurg Psychiatry2000，69，2： | 1 |
| 8 | Electrocardiographic score and short-term outcomes of acute pulmonary embolism显示文摘 | TOOSI M S MERLINO J D LEEPER K V | 2007 | Am J Cardiol2007，100，： | 1 |
| 9 | Recovery from optic neuritis is associated with a change in the distribution of cerebral response to visual stimulation:a functional magnetic resonance imaging study显示文摘 | Werring DJ Bullmore ET Toosy AT | 2000 | Neurol Neurosurg Psychiatry2000，68，4： | 1 |
| 10 | Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke显示文摘 | Wetting D J Toosy AT Clark CA | 2000 | J Neurol N eurosurg Psychiatry2000，69，2： | 1 |
| 11 | Asymmetrical activation of human visual cortex demonstrated by functional MRI with monocular stimulation显示文摘 | Toosy AT Werring DJ Plant GT | 2001 | Neuroimage2001，14，3： | 1 |
| 12 | From diffusion tractography to quantitative white matter:a reproducibility study显示文摘 | Ciccarelli O Parker GJM Toosy AT | 2003 | Neuroimaging2003，18，： | 1 |
| 13 | Diffusion ten- sor imaging can detect and quantify corticospinal tract de- generation after stroke 显示文摘 | Werring DJ Toosy AT Clark CA | 2000 | J Neurol Neurosurg Psychia- try2000，69，2： | 1 |
| 14 | Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke显示文摘 | Werring DJ Toosy AT Clark CA | 2000 | J Neurol Neurosurg Psychiatry2000，69，2： | 1 |
| 15 | Serial magnetization transfer imaging in acute optic neuritis显示文摘 | Hickman SJ Toosy AT Jones SJ | 2004 | Brain2004，127，3： | 1 |
| 16 | Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke 显示文摘 | Werring DJ Toosy AT Clark CA | 2000 | J Neurol Neurosurg Psychiatry2000，69，2： | 1 |
| 17 | Relation of Helicobacter pylori infection and coronary heart disease显示文摘 | Mendall M A Goggin P M Molineaux N Levy J Toosy T Strachan D | 1994 | Br Heart J1994，71，： | 1 |
| 18 | Electrocardiographical score and short-term outcomes of acute pulmonary embolism显示文摘 | Toosi MS Merlino JD Leeper KV | | 0，，： | 1 |
| 19 | Bio- char adsorbed ammonia is bioavailable 显示文摘 | Taghizadeh - Toosi A Clough T J Sherlock R R | 2012 | Plant and Soil2012，350，12： | 1 |
| 20 | Characterizing function structure relationships in the human visual system with functional MRI and diffusion tensor imaging显示文摘 | Toosy AT Cieearelli O Parker GJ | 2004 | Neuroimage2004，21，4： | 1 |
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