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| 1 | FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。 | Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 | 2006 | 中国循证医学杂志2006，6，6： | 3 |
| 2 | Renoprotective and anti hypertensive effects of combined valsartan and perindopril in progressive diabetic nephropathy in the transgenic(mRen-2) 27 rat显示文摘 | Otsm Mackenzie H S Tory J L | 2001 | Nephrol Dial Transplant2001，16，7： | 1 |
| 3 | Bimatoprostand travoprost:a review of recent studies of two new glaucomadrugs显示文摘 | EISENBERG D L TORIS C B CAMRAS C B | 2002 | Surv Ophthalmol2002，47，1： | 1 |
| 4 | Effects of combination therapy with enapril and losartan on the rate of progression of renal injury in rats with 5/6 renal mass abation显示文摘 | Ots M Machenzie H S Tory J L | 1998 | J Am Soc Nephrol1998，9，2： | 1 |
| 5 | Generating new product ideas: An initial investigation of role of market information and organizational characteristics 显示文摘 | Tory L C Szymanski M D Varadarjan R P | 2001 | Journal of the Academy of Marketing Science2001，29，1： | 1 |
| 6 | An analytical model for short-channel organic thin-film transistors 显示文摘 | Toris L Dodabalapur A Katz H E | 1995 | Journal of Applied Physics1995，78，2： | 1 |
| 7 | Guideline implementation fails to improve thrombolytic administration 显示文摘 | Kinsman L Tori K Endacott R | 2007 | Accid Emerg Nurs2007，15，1： | 1 |
| 8 | Computer simulation and experiments on two-phase flow in an inclined sedimentation vessel 显示文摘 | HARALD L TORY | 1997 | Pow- der Technology1997，94，： | 1 |
| 9 | Ant-based phyloge- netic reconstruction (ABPR) :a new distance algorithm for phyloge- netic estimation based on ant colony optimization 显示文摘 | VI/TORI K DELBEM A C B PEREIRA S L | 2008 | Genetics and Molecular Biology2008，31，4： | 1 |
| 10 | muti- ca 显示文摘 | Maldonado E Teresa R A Perez-Castorena A L Anti-inflamma- tory activity of phenyl propanoids from Coreopsis mutica var | 1998 | Planta Med1998，64，： | 1 |
| 11 | Effects of a prostaglandin DP receptor agonist,AL-6598,on aqueous humor dynamics in a nonhuman primate model of glaucoma显示文摘 | Zhan G L Feilmeier M R | 2006 | J Ocul Pharmacol Ther2006，22，2： | 1 |
| 12 | Aqueous humor dynamics in monkeys with laser-induced glaucoma显示文摘 | Toris C B Zhan G L Wang Y L Zhao J McLaughlin M A Camras C B | 2000 | J Ocul Pharmacol Ther2000，16，： | 1 |
| 13 | Unexpected ecotone dynamics of a sand dune vegetation complex following water table decline显示文摘Aims Central Hungarian inland dune ranges harbor heterogeneous grassland vegetation with an extensive network of ecotones,arranged perpendicular to topography-driven hydrologic gradients.The area suffers from severe aridification due to climate change and local anthropogenic factors,which have led to a dramatic decline of the water table.As a result,groundwater is no longer reachable for lowlying plant communities;thus,we expect they are bound to undergo profound changes.This study investigates how the plant communities respond to this changing environment over time by monitoring ecotones,since they are frequently the hotspots of ecosystem change.We monitored five ecotones along permanent belt transects for 15 years to characterize their dynamic response,and to identify the internal structural changes of the plant communities the ecotones delimit.Methods Ecotones were delineated with the split moving window technique.The dynamics of two ecotone parameters,location and contrast,were analyzed with linear regression models incorporating two independent variables:study year as a measure of time since the loss of groundwater,and precipitation as a possible driver of interannual variations.The internal changes of the patches separated by the ecotones were analyzed using plant functional groups.Important Findings Precipitation had no detectable effect on the ecotone descriptors,but study year influenced ecotones in an unusual fashion.The position of the ecotones appeared to be very stable in time;their dynamics are stationary,not directional as we predicted.The contrasts had clear tendencies;two ecotones disappeared,one new one was formed and two ecotones showed no trend.The internal changes of the patches over time were dramatic,showing a shift toward more xeric and more open plant assemblages in most stretches of the transects.Thus,the dynamic response of the vegetation was not patch expansion vs.shrinking,but fusion vs.division,which profoundly restructured the vegetation pattern.Analysis of plant functional groups revealed that the trends of the ecotone contrasts could be traced back to internal changes of the patches and not to processes within ecotones.Hence,in situations where stationary ecotone dynamics prevail,ecotone position may be a poor indicator of the effects of strong directional environmental changes.However,in this study we show that ecotone contrast can serve as a sensitive tool for monitoring landscape pattern transformations in these cases.Also,this highlights the long-term nature of ecotone responses,which can have implications in landscape planning and restoration measures. | Csaba Tölgyesi Márta Zalatnai LászlóErdős Zoltán Bátori Nicole Rosemary Hupp LászlóKörmöczi | 2016 | Journal of Plant Ecology2016，9，1： | 0 |
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