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| 1 | Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease显示文摘AIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease.METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease(MELD) and Pediatric End Stage Liver Disease(PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition(Z-score <-1.00) and malnutrition(Z-score <-2.00). Interleukin-1β(IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status. RESULTS: The median(25th-75 th centile) age of the study population was 60(17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease(72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk(34.9%) compared with those who were well-nourished [7.12(0.58-34.23) pg/m L vs 1.63(0.53-3.43) pg/m L; P = 0.02], correlating inversely with triceps skinfold-for-age z-score(rs =-0.61; P < 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score(P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients. | Daniele Santetti Maria Inês de Albuquerque Wilasco Cristina Toscani Leal Dornelles Isabel Cristina Ribas Werlang Fernanda Urruth Fontella Carlos Oscar Kieling Jorge Luiz dos Santos Sandra Maria Goncalves Vieira Helena Ayako Sueno Goldani | 2015 | World Journal of Gastroenterology2015，21，29： | 2 |
| 2 | The uhrapotassic rocks: Characteristics, classification, and constraints for petrogenetic models显示文摘 | Foley S F Venturelli G Green D H Toscani L | 1987 | Earth Sci Rev1987，24，2： | 1 |
| 3 | Kinetic models of opinion formation显示文摘 | Toscani G | 2006 | Communications in Mathematical Sciences2006，4，3： | 1 |
| 4 | Exponential time decay of solutions to a nonlinear fourth-order parabolic equation显示文摘 | A Jüngel G Toscani | 2003 | Z Angew Math Phys2003，54，： | 1 |
| 5 | Human heart rate variability and sleep stages显示文摘 | Toscani L Gangemi PF Parigi A | 1996 | Ital J Neurol Sci1996，17，： | 1 |
| 6 | Multi-stage rodingitization of ophiolitic bodies from Northern Apennines(Italy): Constraints from petrography, geochemistry and thermodynamic modelling显示文摘The investigated mantle bodies from the External Ligurians(Groppo di Gorro and Mt.Rocchetta)show evidences of a complex evolution determined by an early high temperature metasomatism,due to percolating melts of asthenospheric origin,and a later metasomatism at relatively high temperature by hydrothermal fluids,with formation of rodingites.At Groppo di Gorro,the serpentinization and chloritization processes obliterated totally the pyroxenite protolith,whereas at Mt.Rocchetta relics of peridotite and pyroxenite protoliths were preserved from serpentinization.The rodingite parageneses consist of diopside+vesuvianite+garnet+calcite+chlorite at Groppo di Gorro and garnet+diopside+serpentine±vesuvianite±prehnite±chlorite±pumpellyite at Mt.Rocchetta.Fluid inclusion measurements show that rodingitization occurred at relatively high temperatures(264-334℃ at 500 bar and 300-380℃ at 1 kbar).Garnet,the first phase of rodingite to form,consists of abundant hydrogarnet component at Groppo di Gorro,whereas it is mainly composed of grossular and andradite at Mt.Rocchetta.The last stage of rodingitization is characterized by the vesuvianite formation.Hydrogarnet nucleation requires high Ca and low silica fluids,whereas the formation of vesuvianite does not need CO2-poor fluids.The formation of calcite at Groppo di Gorro points to mildly oxidizing conditions compatible with hydrothermal fluids;the presence of andradite associated with serpentine and magnetite at Mt.Rocchetta suggests Fe^3+-bearing fluids with fO2 slightly higher than iron-magnetite buffer.We propose that the formation of the studied rodingite could be related to different pulses of hydrothermal fluids mainly occurring in an oceancontinent transitional setting and,locally,in an accretionary prism associated with intra-oceanic subduction. | Emma Salvioli-Mariani Tiziano Boschetti Lorenzo Toscani Alessandra Montanini Jasmine Rita Petriglieri Danilo Bersani | 2020 | Geoscience Frontiers2020，11，6： | 1 |
| 7 | A fast, simplified frequency-domain interpolation method for the evaluation of the frequency and amplitude of spectral components 显示文摘 | FERRERO A SALICONE S TOSCANI S | 2011 | IEEE Transactions on Instrumentation and Measurement2011，60，5： | 1 |
| 8 | Thermodynamic study of sulfanilamide polymorphism:(Ⅰ) monotropy of the a-variety显示文摘 | Toscani S Thoren S Agafonov V | 1995 | Pharm Res1995，12，10： | 1 |
| 9 | Long-time Asymptotics for Strong Solutions of the Thin Films Equation 显示文摘 | Carrillo J A Toscani G | 2002 | Commun Math Phys2002，225，： | 1 |
| 10 | Exponential Decay in Time of Solutions to a Nonlinear Fourth-order Parabolic Equation 显示文摘 | Jungel A Toscani G | 2003 | Z Angew Math Phys2003，54，3： | 1 |
| 11 | Arrest of spermatogenesis and defective breast development in mice lacking A-myb显示文摘 | Toscani A Mettus RV Coupland R | 1997 | Nature1997，386，6626： | 1 |
| 12 | Single follicular unit hair transplantation to restore eyebrows 显示文摘 | Toscani M Fioramonti P Ciotti M | 2011 | Dermatol Surg2011，37，8： | 1 |
| 13 | The dissipative linear Boltzmann equation显示文摘 | Spiga G Toscani G | 2004 | Applied Mathematics Letters2004，17，： | 1 |
| 14 | Kinetic models of opinion formation显示文摘 | Toscani G | 2006 | Communications in Mathematical Sciences2006，4，3： | 1 |
| 15 | Immunoexpression of endoglin in brain metastasis secondary to malignant melanoma:evaluation of angiogenesis and comparison with brain metastasis secondary to breast and lung carcinomas显示文摘 | Salgado KB Toscani NV Silva LL | 2007 | Clin Exp Metastasis2007，24，6： | 1 |
| 16 | Influence of abiotic parameters on ochratoxin A production by a Penicillium nordicum strain in dry-cured meat model systems显示文摘 | BATTILANI P FORMENTI S TOSCANI T etal | 2010 | Food Control2010，21，12： | 1 |
| 17 | On the non-linear Boltzmann equation in unbounded domains显示文摘 | G. Toscani | 1986 | Archive for Rational Mechanics and Analysis1986，，1： | 1 |
| 18 | Arrest of spermatogenesis and defectivebreast development in mice lacking A-myb显示文摘 | Toscani A Mettus RV Coupland R | 1997 | Nature1997，386，6626： | 1 |
| 19 | Estimation of truncal adiposity using waist circumference or the sum of trunk skinfolds: a pilot study for insulin resistance screening in hirsute patients with or without polycystic ovary syndrome显示文摘 | Toscani M Migliavacca R Sisson de Castro JA | 2007 | Metabolism2007，56，7： | 1 |
| 20 | A fast,simplified frequency-domain interpolation method for the evaluation of the frequency and amplitude of spectral components显示文摘 | Ferrero A Salicone S Toscani S | 2011 | IEEE Transactions on Instrumentation and Measurement2011，60，5： | 1 |
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