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| 1 | Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma显示文摘AIM To evaluate the inhibitory effects of deferasirox(DFX) against hepatocellular carcinoma(HCC) through basic and clinical studies.METHODS In the basic study, the effect of DFX was investigated in three hepatoma cell lines(Hep G2, Hep3 B, and Huh7), as well as in an N-nitrosodiethylamine-induced murine HCC model. In the clinical study, six advanced HCC patients refractory to chemotherapy were enrolled. The initial dose of DFX was 10 mg/kg per day and was increased by 10 mg/kg per day every week, until the maximum dose of 30 mg/kg per day. The duration of a single course of DFX therapy was 28 consecutive days. In the event of dose-limiting toxicity(according to the Common Terminology Criteria for Adverse Events v.4.0), DFX dose was reduced.RESULTS Administration of DFX inhibited the proliferation of hepatoma cell lines and induced the activation of caspase-3 in a dose-dependent manner in vitro. In the murine model, DFX treatment significantly suppressed the development of liver tumors(P < 0.01), and significantly upregulated the mR NA expression levels of hepcidin(P < 0.05), transferrin receptor 1(P < 0.05), and hypoxia inducible factor-1α(P < 0.05) in both tumor and non-tumor tissues, compared with control mice. In the clinical study, anorexia and elevated serum creatinine were observed in four and all six patients, respectively. However, reduction in DFX dose led to decrease in serum creatinine levels in all patients. After the first course of DFX, one patient discontinued the therapy. We assessed the tumor response in the remaining five patients; one patient exhibited stable disease, while four patients exhibited progressive disease. The one-year survival rate of the six patients was 17%.CONCLUSION We demonstrated that DFX inhibited HCC in the basic study, but not in the clinical study due to dose-limiting toxicities. | Issei Saeki Naoki Yamamoto Takahiro Yamasaki Taro Takami Masaki Maeda Koichi Fujisawa Takuya Iwamoto Toshihiko Matsumoto Isao Hidaka Tsuyoshi Ishikawa Koichi Uchida Kenji Tani Isao Sakaida | 2016 | World Journal of Gastroenterology2016，22，40： | 3 |
| 2 | Lead-free Piezoceramics 显示文摘 | Yasuyoshi Saito Hisaaki Takao Toshihiko Tani | 2004 | Nature2004，432，： | 1 |
| 3 | Piezoelectric properties of bismuth layer structured ferroelectric ceramics with a preferred orientation processed by the reactive templated grain growth method显示文摘 | TSUGUTO TAKEYCHI TOSHIHIKO TANI | 1999 | Jpn J Appl Phys1999，389，： | 1 |
| 4 | Microcomposite particles Sr3Ti2OT-SrTiO3 with an epitaxial core-shell structure显示文摘 | Tsuguto Takeuchi Toshihiko Tani Toshikazu Satoh | 1998 | Solid State Ionics1998，108，： | 1 |
| 5 | Undirectionally texturede CaBi4Ti4O5 ceramics by the reactive templated grain growth method显示文摘 | Tsuguto Takeuchi Toshihiko Tani Yasuyoshi Saito | 2000 | Jpn J Appl Phys2000，39，： | 1 |
| 6 | Lead-free Piezoceramics显示文摘 | Yasuyoshi Saito Hisaaki Takao Toshihiko Tani | 2004 | Nature2004，432，4： | 1 |
| 7 | Lead-free piezoceramics 显示文摘 | Yasuyoshi Saito Hisaaki Takao Toshihiko Tani | 2004 | Nature2004，432，： | 1 |
| 8 | Piezoelectric properties of bismuth layer structured ferroleectric ceramics with a preferred orientation processed by the reactive templated grain growth method显示文摘 | TSUGUTO Takeychi TOSHIHIKO Tani | 1999 | Jpn J Appl Phys1999，389，： | 1 |
| 9 | Lead-free piezoelectrics显示文摘 | Yasuyoshi Saito Hisaaki Takao Toshihiko Tani | 2004 | Nature2004，432，： | 1 |
| 10 | Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): part 4. Establishment of equations for severity scores显示文摘 | Mitsuru Fukui Kazuhiro Chiba Mamoru Kawakami Shinichi Kikuchi Shinichi Konno Masabumi Miyamoto Atsushi Seichi Tadashi Shimamura Osamu Shirado Toshihiko Taguchi Kazuhisa Takahashi Katsushi Takeshita Toshikazu Tani Yoshiaki Toyama Kazuo Yonenobu Eiji Wada T | 2008 | Journal of Orthopaedic Science2008，，1： | 1 |
| 11 | An outcome measure for patients with cervical myelopathy: Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): Part 1显示文摘 | Mitsuru Fukui Kazuhiro Chiba Mamoru Kawakami Shin-ichi Kikuchi Shin-ichi Konno Masabumi Miyamoto Atsushi Seichi Tadashi Shimamura Osamu Shirado Toshihiko Taguchi Kazuhisa Takahashi Katsushi Takeshita Toshikazu Tani Yoshiaki Toyama Eiji Wada Kazuo Yonenobu | 2007 | Journal of Orthopaedic Science2007，，3： | 1 |
| 12 | Lead-Free Piezoceramics显示文摘 | SAITO Yasuyoshi TAKAO Hisaaki TANI Toshihiko | 2004 | Nature2004，432，： | 1 |
| 13 | Thermoelectric properties of highly textured NaCo2O4 ceramics processed by the reactive templated grain growth (RTGG) method显示文摘 | Toshihiko Tani Shinya Isobe | 2001 | Materials Science and Engineering2001，86，2001： | 1 |
| 14 | Microcomposite particles Sr3Ti2O7- SrTiO3 with an epitaxial core-shell structure显示文摘 | Tsuguto Takeuehi Toshihiko Tani Toshikazu Satoh | 1998 | Solid State lonics1998，108，： | 1 |
| 15 | Effect of potassium concentration on the grain orientation in bismuth sodium potassium titallate显示文摘 | Eiichiro Fukuchi Toshio Kimura Toshihiko Tani | 2002 | J Am Ceram Soc2002，85，6： | 1 |
| 16 | Effect of potassium concentration on the grain orientation in bismuth sodium potassium titanate 显示文摘 | Eiichiro Fukuchi Toshio Kimura Toshihiko Tani | 2002 | J Am Ceram Soc2002，85，6： | 1 |
| 17 | Lead-free piezoceramics 显示文摘 | Yasuyoshi Saito Hisaaki Takao Toshihiko Tani | 2004 | Nature2004，432，4： | 1 |
| 18 | Texture development of SrTiO3 ceramics during reactive templated grain growth 显示文摘 | TAKEUCHI Tsuguto TANI Toshihiko | 2002 | J Ceram Soc Jpn2002，110，1280： | 1 |
| 19 | Piezoelectric properties of bismuth layer-structure ferroelectric ceramics with a preferred orientation processed by the reactive templated grain growth method 显示文摘 | Toshihiko Tani Yasuyoshi Saito | 1999 | Jpn J Appl Phys1999，38，： | 1 |
| 20 | Unidirectionally textured CaBi4Ti4O15 ceramics by the reactive templated grain growth with an extrusion 显示文摘 | Toshihiko Tani Yasuyoshi Saito | 2000 | Jpn J Appl Phys2000，39，： | 1 |
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