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| 1 | Nutrition and exercise in the management of liver cirrhosis显示文摘Liver cirrhosis(LC)patients often have protein-energy malnutrition(PEM)and decreased physical activity.These conditions often lead to sarcopenia,which is the loss of skeletal muscle volume and increased muscle weakness.Recent studies have demonstrated that PEM and sarcopenia are predictors for poor survival in LC patients.Nutrition and exercise management can improve PEM and sarcopenia in those patients.Nutrition management includes sufficient dietary intake and improved nutrient metabolism.With the current high prevalence of obesity,the number of obese LC patients has increased,and restriction of excessive caloric intake without the exacerbation of impaired nutrient metabolism is required for such patients.Branched chain amino acids are good candidates for supplemental nutrients for both obese and non-obese LC patients.Exercise management can increase skeletal muscle volume and strength and improve insulin resistance;however,nutritional status and LC complications should be assessed before an exercise management regimen is implemented in LC patients.The establishment of optimal exercise regimens for LC patients is currently required.In this review,we describe nutritional status and its clinical impact on the outcomes of LC patients and discuss general nutrition and exercise management in LC patients. | Nobuyuki Toshikuni Tomiyasu Arisawa Mikihiro Tsutsumi | 2014 | World Journal of Gastroenterology2014，20，23： | 20 |
| 2 | Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease显示文摘Alcoholic liver disease(ALD)and nonalcoholic fatty liver disease(NAFLD)are serious health problems worldwide.These two diseases have similar pathological spectra,ranging from simple hepatic steatosis to steatohepatitis,liver cirrhosis,and hepatocellular carcinoma.Although most subjects with excessive alcohol or food intake experience simple hepatic steatosis,a small percentage of individuals will develop progressive liver disease.Notably,both ALD and NAFLD are frequently accompanied by extrahepatic complications,including cardiovascular disease and malignancy.The survival of patients with ALD and NAFLD depends on various disease-associated conditions.This review delineates the clinical characteristics and outcomes of patients with ALD and NAFLD by comparing their epidemiology,the factors associated with disease susceptibility and progression,and the predictors and characteristics of outcomes.A comprehensive understanding of the characteristics and outcomes of ALD and NAFLD is imperative in the management of these chronic liver diseases. | Nobuyuki Toshikuni Mikihiro Tsutsumi Tomiyasu Arisawa | 2014 | World Journal of Gastroenterology2014，20，26： | 13 |
| 3 | Hepatitis C-related liver cirrhosis-strategies for the prevention of hepatic decompensation,hepatocarcinogenesis,and mortality显示文摘Liver cirrhosis(LC)is a critical stage of chronic liver disease,including that caused by hepatitis C virus(HCV).In the absence of antiviral therapy,67%-91%of patients with HCV-related LC patients die of liver-related causes,including hepatocellular carcinoma(HCC)and liver failure.Among the therapeutic strategies used to prevent liver-related complications in these patients is standard therapy with pegylated interferon and ribavirin,which induces a sustained virological response(SVR)in 25%of HCV genotype 1-infected patients and in 69% of patients infected with genotypes 2 and 3.SVR in patients with HCV-related LC has been associated with reduced rates of hepatic decompensation,HCC,and mortality.More recently developed direct-acting antiviral agents have shown excellent antiviral efficacy,with preliminary data demonstrating that an interferon-free regimen that includes these direct-acting antiviral agents achieved SVR in more than 50%of patients with HCV genotype 1 LC.Branched-chain amino acid supplementation,improvement of insulin resistance,and the use ofβ-blockers for portal hypertension may also reduce liverrelated complications.Here,we review advances in antiviral and adjunctive therapies for improved outcomes in patients with HCV-associated LC. | Nobuyuki Toshikuni Tomiyasu Arisawa Mikihiro Tsutsumi | 2014 | World Journal of Gastroenterology2014，20，11： | 10 |
| 4 | Dermatomyositis associated with hepatocellular carcinoma in an elderly female patient with hepatitis C virus-related liver cirrhosis显示文摘有丙肝的一个 79 岁的女病人病毒相关的肝肝硬化作为与 2.0 厘米的一条直径有肝细胞癌(HCC ) 被诊断。她为 HCC 拒绝了治疗。在诊断以后的九个月,当 HCC 扩大了到 6.0 厘米的一条直径时,她开发了皮肤肌炎。她为皮肤肌炎,然后 transcatheter 经历了治疗为 HCC 的动脉的 chemoembolization。尽管皮肤肌炎的表明改善了,全部肿瘤坏死被完成,她在 HCC 的治疗以后死于肺病 2 瞬间。HCC 或长期的丙肝病毒感染可能涉及皮肤肌炎的致病。 | Nobuyuki Toshikuni Rikako Torigoe Mikio Mitsunaga Akiyoshi Omoto Koji Nakashima | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 5 | Shear wave elastography in hepatitis C patients before and after antiviral therapy显示文摘AIM To investigate shear wave(SW) propagation velocity in patients with untreated hepatitis C and patients with sustained virological response(SVR). METHODS A total of 136 hepatitis C patients [85 patients who had not received antiviral therapy(na?ve group) and 51 patients who had received antiviral therapy and subsequently achieved SVR of at least 24 wk(SVR group)] and 58 healthy volunteers and outpatients without liver disease(control group) underwent evaluation of liver stiffness by SW elastography(SWE). Various parameters were evaluated in the chronic hepatitis C patients at the time of SWE.RESULTS SW propagation velocity(Vs) was 1.23 ± 0.14 m/s in the control group, 1.56 ± 0.32 m/s in the SVR group, and 1.69 ± 0.31 m/s in the na?ve group. Significant differences were seen between the control group and the SVR group(P = 0.0000) and between the SVR group and the na?ve group(P = 0.01417). All four fibrosis markers were higher in the na?ve group than in the SVR group. In the na?ve group, Vs was positively correlated with alanine aminotransferase(ALT)(r = 0.5372), α feto protein(AFP)(r = 0.4389), type Ⅳ collagen(r = 0.5883), procollagen Ⅲ peptide(P-Ⅲ-P)(r = 0.4140), hyaluronic acid(r = 0.4551), and Mac-2 binding protein glycosylation isomer(M2BPGi)(r = 0.6092) and negatively correlated with albumin(r =-0.4289), platelets(r =-0.5372), and prothrombinactivity(r =-0.5235). On multiple regression analysis, Vs was the most strongly correlated with ALT(standard partial regression std β = 0.4039, P = 0.00000). In the SVR group, Vs was positively correlated with AFP(r = 0.6977), type IV collagen(r = 0.5228), P-Ⅲ-P(r = 0.5812), hyaluronic acid(r = 0.5189), and M2BPGi(r = 0.6251) and negatively correlated with albumin(r =-0.4283), platelets(r =-0.4842), and prothrombin activity(r =-0.4771). On multiple regression analysis, Vs was strongly correlated with AFP(standard partial regression std β = 0.5953, P = 0.00000) and M2BPGi(standard partial regression std β = 0.2969, P = 0.03363).CONCLUSION In hepatitis C patients, liver stiffness is higher in treatment-na?ve patients than in those showing SVR. SWE may be a predictor of hepatocarcinogenesis in SVR patients. | Toshikuni Suda Osamu Okawa Rion Masaoka Yoshinori Gyotoku Naohiko Tokutomi Yasumi Katayama Masaya Tamano | 2017 | World Journal of Hepatology2017，9，1： | 4 |
| 6 | Association of primary biliary cirrhosis with idiopathic thrombocytopenic purpura显示文摘Although both primary biliary cirrhosis (PBC) and idiopathic thrombocytopenic purpura (ITP) are autoimmune diseases, the association of the 2 diseases is rare. Here, we report a case of ITP that developed during the follow-up of PBC in a 74-year- old man. The patient had been diagnosed with PBC 12 years previously, and had received treatment with ursodeoxycholic acid. The platelet count decreased from approximately 60 × 109/L to 8 × 109/L, and the association of decompensated liver cirrhosis (PBC) with ITP was diagnosed. Steroid and immune gamma globulin therapy were successful in increasing the platelet count. Interestingly, human leukocyte antigen genotyping detected the alleles DQB10601 and DRB10803, which are related to both PBC and ITP in Japanese patients. This case suggests common immunogenetic factors might be involved in the development of PBC and ITP. | Nobuyuki Toshikuni Ryumei Yamato Haruhiko Kobashi Ken Nishino Nobu Inada Ritsuko Sakanoue Mitsuhiko Suehiro Yoshinori Fujimura Gotaro Yamada | 2008 | World Journal of Gastroenterology2008，14，15： | 2 |
| 7 | Overexpression of β3/γ2 chains of laminin-5 and MMP7 in biliary cancer显示文摘AIM:To clarify the clinicopathological significance of laminin-5 γ2 (LNγ2) and β3 (LNβ3) chains and MMP7 expression in biliary tract cancer.METHODS: We analyzed the association between immunohistochemically detected LNγ2, LNβ3, and MMP7 expression in biliary tract cancer and clinicopathological characteristics. Activity of MMP7 was analyzed by casein zymography. An in vitro invasion assay after treatment with MMP7-specific siRNA was performed.RESULTS: LNγ2 expression was predominantly observed in carcinoma cells at the invasive front. LNγ2 expression was seen in 57% of patients with biliary tract cancer, and was associated with depth of invasion, histologic type, and advanced stage. The expression pattern of LNβ3 was classified into two types: invasive front dominant type (38%) and diffuse type (28%).The invasive front dominant type was associated with histologic type and advanced stage. MMP7 positivity was correlated with LNγ2 or LNβ3 expression but not with clinicopathological characteristics. Active MMP7 detected by casein zymography was correlated with depth of invasion and advanced stage. Downregulation of MMP7 expression by siRNA resulted in a significant decrease in biliary tract cancer cell invasion in vitro.CONCLUSION: Our results suggest that LNγ2 and LNβ3, in conjunction with MMP7, play a key role in the progression of biliary tract cancer. | Toshikuni Oka Hiroyuki Yamamoto Shigeru Sasaki Masanori Ii Keiichi Hizaki Hiroaki Taniguchi Yasushi Adachi Kohzoh Imai Yasuhisa Shinomura | 2009 | World Journal of Gastroenterology2009，15，31： | 2 |
| 8 | Preparation of plastic optical fiber for near-IR region transmission 显示文摘 | Toshikuni Kaino | 1987 | J of Polymer Science Part A: Polymer Chemistry1987，25，： | 1 |
| 9 | Expression of telomer- ase associated protein 1 and telomerase transcriptase in hepato- cellular carcinoma显示文摘 | Toshikuni N Nouso K Higashi T | 2000 | Br J Cancer2000，82，6： | 1 |
| 10 | Expression of telomerase-associated protein 1 and telomerase reverse transcriptase in hepatocellular carcinoma显示文摘 | Toshikuni N | 2000 | Br J Cancer2000，82，4： | 1 |
| 11 | Advanced ultrasonography technologies to assess the effects of radiofrequency ablation on hepatocellular carcinoma显示文摘 | Toshikuni N Shiroeda H Ozaki K | 2013 | Radiol Oncol2013，47，3： | 1 |
| 12 | Expression of telomerase-associated protein 1 and telomerase reverse transcriptase in hepatocellular carcinoma显示文摘 | Toshikuni N Nouso K Higashi T | 2000 | Br J Cancer2000，82，4： | 1 |
| 13 | Radiotherapy for multiple brain metastases from hepatocellular carcinomas显示文摘A 78-year-old man with liver cirrhosis was foundto have multiple hepatocellular carcinomas (HCCs)and underwent 3 sessions of transcatheter arterialchemoembolization. Fourteen months after diagnosis,the patient presented with left hemiparesis. Contrast-enhanced magnetic resonance imaging showed multiplemetastases with ring-shaped enhancement in thecerebrum and cerebellum. There were no metastases toother organs. The metastatic lesions almost completelydisappeared after whole-brain radiotherapy with atotal dose of 50 Gy. Neurologic symptoms decreased,and the patient's quality of life improved. The patientunderwent 2 more sessions of transcatheter arterialchemoembolization. Twelve months after the diagnosisof brain metastasis, the patient remains alive. Thepresent case indicates that radiotherapy can improvequality of life and prolong survival in some patients withbrain metastases from HCCs. | Nobuyuki Toshikuni Kazuhiko Morii Michinori Yamamoto | 2007 | World Journal of Gastroenterology2007，13，33： | 1 |
| 14 | Expression of telomerase- associated protein and telomerase reverse transcriptase in hepatocellular carcinoma 显示文摘 | Toshikuni N Nouso K Higashi T | 2000 | Br J Cancer2000，82，4： | 1 |
| 15 | Advancedultrasonography technologies to assess the effects ofradiofrequency ablation on hepatocellular carcinoma 显示文摘 | Toshikuni N Shiroeda H Ozaki K | 2013 | RadiolOncol2013，47，3： | 1 |
| 16 | Elevated serum gatnma-glutamyl transpeptidase levels and fatty liver strongly predict the presence of carotid plaque 显示文摘 | Toshikuni N Asaji T Nakanishi Y | 2015 | J Atheroscler Thromb2015，22，10： | 1 |
| 17 | Elevated serum gamma-glutamyl transpeptidase levels and fatty liver strongly predict the presence of carotid plaque显示文摘 | Toshikuni N Asaji T Nakanishi Y | 2015 | J Atheroseler Thromb2015，22，10： | 1 |
| 18 | Comparison of outcomes between patients with alcoholic cirrhosis and those with hepatitis C virus - related cirrhosis 显示文摘 | Toshikuni N Izumi A N ishino K | 2009 | J Gastroenterol Hepatol2009，24，7： | 1 |
| 19 | Biodiesel production using anionic ion-exchange resin as heterogeneous catalyst显示文摘 | Naomi Shibasaki-Kitakawa Hiroki Honda Homare Kuribayashi Takuji Toda Takuya Fukumura Toshikuni Yonemoto | 2005 | Bioresource Technology2005，，2： | 1 |
| 20 | Covering anodized aluminum with electropolymerized polypyrrole via manganese oxide layer and application to solid electrolytic capacitor显示文摘 | Kudoh Yasuo Kojima Toshikuni | 1996 | Journal of Power Sources1996，60，2： | 1 |
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