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| 1 | Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy显示文摘Acute appendicitis(AA) develops in a progressive and irreversible manner, even if the clinical course of AA can be temporarily modified by intentional medications. Reliable and real-time diagnosis of AA can be made based on findings of the white blood cell count and enhanced computed tomography. Emergent laparoscopic appendectomy(LA) is considered as the first therapeutic choice for AA. Interval/delayed appendectomy at 6-12 wk after disease onset is considered as unsafe with a high recurrent rate during the waiting time. However, this technique may have some advantages for avoiding unnecessary extended resection in patients with an appendiceal mass. Nonoperative management of AA may be tolerated only in children. Postoperative complications increase according to the patient's factors, and temporal avoidance of emergent general anesthesia may be beneficial for high-risk patients. The surgeon's skill and cooperation of the hospital are important for successful LA. Delaying appendectomy for less than 24 h from diagnosis is safe. Additionally, a semi-elective manner(i.e., LA within 24 h after onset of symptoms) may be paradoxically acceptable, according to the factors of the patient, physician, and institution. Prompt LA is mandatory for AA. Fortunately, the Japanese government uses a universal health insurance system, which covers LA. | tomohide hori takafumi machimoto yoshio kadokawa toshiyuki hata tatsuo ito shigeru kato daiki yasukawa yuki aisu yusuke kimura maho sasaki yuichi takamatsu taku kitano shigeo hisamori tsunehiro yoshimura | 2017 | World Journal of Gastroenterology2017，23，32： | 18 |
| 2 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 3 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 4 | Role of RANKL/RANK in primary and secondary breast cancer显示文摘Bone is one of the most preferential metastatic target sites of breast cancer. Bone possesses unique biological microenvironments in which various growth factors are stored and continuously released through osteoclastic bone resorption, providing fertile soil for circulating breast cancer cells. Bone-disseminated breast cancer cells in turn produce osteotropic cytokines which modulate bone environments. Under the influences of breast cancer-produced cytokines, osteoblasts express elevated levels of Ligand for receptor activator of nuclear factor-κB(RANKL) and stimulate osteoclastogenesis via binding to the receptor receptor activator of nuclear factor-κB(RANK) and activating its downstream signaling pathways in hematopoietic osteoclast precursors, which causes further osteoclastic bone destruction. Establishment of crosstalk with bone microenvironments(so called vicious cycle) is an essential event for metastatic breast cancer cells to develop bone metastasis. RANKL and RANK play a central role in this crosstalk. Moreover, recent studies have demonstrated that RANKL and RANK are involved in tumorigenesis and distant metastasis independent of bone microenvironments. Pharmacological disruption of the RANKL/RANK interplay should be an effective therapeutic intervention for primary breast tumors and bone and non-bone metastasis. In this context, denosumab, which is neutralizing monoclonal antibody against RANKL, is a mechanismbased drug for the treatment of bone metastases and would be beneficial for breast cancer patients with bone metastases and potentially visceral organ metastases. | Toshiyuki Yoneda Soichi Tanaka Kenji Hata | 2013 | World Journal of Orthopedics2013，4，4： | 5 |
| 5 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 6 | Protocol for laparoscopic cholecystectomy: Is it rocket science?显示文摘Laparoscopic cholecystectomy(LC) does not require advanced techniques, and its performance has therefore rapidly spread worldwide. However, the rate of biliary injuries has not decreased. The concept of the critical view of safety(CVS) was first documented two decades ago. Unexpected injuries are principally due to misidentification of human factors. The surgeon's assumption is a major cause of misidentification, and a high level of experience alone is not sufficient for successful LC. We herein describe tips and pitfalls of LC in detail and discuss various technical considerations.Finally, based on a review of important papers and our own experience, we summarize the following mandatory protocol for safe LC:(1) consideration that a high level of experience alone is not enough;(2) recognition of the plateau involving the common hepatic duct and hepatic hilum;(3) blunt dissection until CVS exposure;(4) Calot's triangle clearance in the overhead view;(5) Calot's triangle clearance in the view from underneath;(6) dissection of the posterior right side of Calot's triangle;(7) removal of the gallbladder body; and(8) positive CVS exposure. We believe that adherence to this protocol will ensure successful and beneficial LC worldwide, even in patients with inflammatory changes and rare anatomies. | Tomohide Hori Fumitaka Oike Hiroaki Furuyama Takafumi Machimoto Yoshio Kadokawa Toshiyuki Hata Shigeru Kato Daiki Yasukawa Yuki Aisu Maho Sasaki Yusuke Kimura Yuichiro Takamatsu Masato Naito Masaya Nakauchi Takahiro Tanaka Daigo Gunji Kiyokuni Nakamura Kiyoko Sato Masahiro Mizuno Taku Iida Shintaro Yagi Shinji Uemoto Tsunehiro Yoshimura | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 7 | Splenectomy Does Not Offer Immunological Benefits in ABO-Incompatible Liver Transplantation With a Preoperative Rituximab显示文摘 | Vikram Raut Akira Mori Toshimi Kaido Yasuhiro Ogura Iida Taku Kazuyuki Nagai Naoya Sasaki Kosuke Endo Toshiyuki Hata Shintaro Yagi Hiroto Egawa Shinji Uemoto | 2012 | Transplantation2012，，1： | 2 |
| 8 | Impact of Hepatic Arterial Reconstruction on Orthotopic Liver Transplantation in the Rat显示文摘 | Tomohide Hori Lindsay B. Gardner Florence Chen Ann-Marie T. Baine Toshiyuki Hata Shinji Uemoto Justin H. Nguyen | 2012 | Journal of Investigative Surgery2012，，4： | 1 |
| 9 | Matrix metalloproteinase-9 after the cold ischemia/reperfusion injury and/or shear stress with portal hypertension: an overview显示文摘 | Tomohide Hori Shinji Uemoto Toshiyuki Hata Lindsay B. Gardner Feng Chen Ann-Marie T. Baine Justin H. Nguyen | | Surgery Today0，，1： | 1 |
| 10 | Liver graft pretreated in vivo or ex vivo by γ -aminobutyric acid receptor regulation显示文摘 | Tomohide Hori Lindsay B. Gardner Florence Chen Ann-Marie T. Baine Toshiyuki Hata Shinji Uemoto Justin H. Nguyen | 2012 | Journal of Surgical Research2012，，： | 1 |
| 11 | Ante natal Diagnosis of Persistent Right Umbilical Vein显示文摘 | Yasuhide Ariyuki Toshiyuki Hata Atsushi Manabe | 1995 | Clin Ultrasound1995，23，： | 1 |
| 12 | Antenatal diagnosis of persistent right umbilical vein in the fetus显示文摘 | Yasuhide Ariyuki Toshiyuki Hata Atsushie Manabe | 1995 | Clin Ultrasound1995，23，： | 1 |
| 13 | Antenatal Diagnosis of Persistent Right Umbilical Vein 显示文摘 | Yasuhide Ariyuki Toshiyuki Hata Atsushi Manahe | 1995 | Clin Ultrasound1995，23，： | 1 |
| 14 | Splenectomy Does Not Offer Immunological Benefits in ABO-Incompatible Liver Transplantation With a Preoperative Rituximab显示文摘 | Vikram Raut Akira Mori Toshimi Kaido Yasuhiro Ogura Iida Taku Kazuyuki Nagai Naoya Sasaki Kosuke Endo Toshiyuki Hata Shintaro Yagi Hiroto Egawa Shinji Uemoto | 2012 | Transplantation2012，，1： | 1 |
| 15 | Heart pulse monitoring system by air pressure and ultrasonic sensor systems显示文摘 | Yutaka Hata Yuya Kamozaki Toshiyuki Sawayama | 2007 | System of Systems Engineering2007，1618，： | 1 |
| 16 | Induction heating for desorption of surface contamination for high-repetition laser-driven carbon-ion acceleration显示文摘This study reports the first experimental demonstration of surface contamination cleaning from a high-repetition supply of thin-tape targets for laser-driven carbon-ion acceleration.The adsorption of contaminants containing protons,mainly water vapor and hydrocarbons,on the surface of materials exposed to low vacuum(>10^(−3)Pa)suppresses carbon-ion acceleration.The newly developed contamination cleaner heats a 5-μm-thick nickel tape to over 400℃in 100 ms by induction heating.In the future,this heating method could be scaled to laserdriven carbon-ion acceleration at rates beyond 10 Hz.The contaminant hydrogen is eliminated from the heated nickel surface,and a carbon source layer—derived from the contaminant carbon—is spontaneously formed by the catalytic effect of nickel.The species of ions accelerated from the nickel film heated to various temperatures have been observed experimentally.When the nickel film is heated beyond∼150℃,the proton signal considerably decreases,with a remarkable increase in the number and energy of carbon ions.The Langmuir adsorption model adequately explains the temperature dependence of desorption and re-adsorption of the adsorbed molecules on a heated target surface,and the temperature required for proton-free carbon-ion acceleration can be estimated. | Sadaoki Kojima Tatsuhiko Miyatake Hironao Sakaki Hiroyoshi Kuroki Yusuke Shimizu Hisanori Harada Norihiro Inoue Thanh Hung Dinh Masayasu Hata Noboru Hasegawa Michiaki Mori Masahiko Ishino Mamiko Nishiuchi Kotaro Kondo Masaharu Nishikino Masaki Kando Toshiyuki Shirai Kiminori Kondo | 2023 | Matter and Radiation at Extremes2023，8，5： | 0 |
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