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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Accuracy of biometric formulae for intraocular lens power calculation in a teaching hospital显示文摘AIM: To evaluate the accuracy of three commonly used biometric formulae across different axial lengths(ALs) at one United States Veterans Affairs teaching hospital.METHODS: A retrospective chart review was conducted from November 2013 to May 2018. One eye of each patient who underwent cataract surgery with a monofocal intraocular lens(IOL) was included. The range of postoperative follow-up period was from 3 wk to 4 mo. The Holladay 2, Barrett Universal II, and Hill-Radial Basis Function(Hill-RBF) formulae were used to predict the postoperative refraction for all cataract surgeries. For each formula, we calculated the prediction errors [including mean absolute prediction error(MAE)] and the percentage of eyes within ±0.25 diopter(D) and ±0.5 D of predicted refraction. We performed subgroup analyses for short(AL<22.0 mm), medium(AL 22.0-25.0 mm), and long eyes(AL>25.0 mm).RESULTS: A total of 1131 patients were screened, and 909 met the inclusion criteria. Resident ophthalmologists were the primary surgeons in 710(78.1%) cases. We found no statistically significant difference in predictive accuracy among the three formulae over the entire AL range or in the short, medium, and long eye subgroups. Across the entire AL range, the Hill-RBF formula resulted in the lowest MAE(0.384 D) and the highest percentage of eyes with postoperative refraction within ±0.25 D(42.7%) and ±0.5 D(75.5%) of predicted. All three formulae had the highest MAEs(>0.5 D) and lowest percentage within ±0.5 D of predicted refraction(<55%) in short eyes.CONCLUSION: In cataract surgery patients at our teaching hospital, three commonly used biometric formulae demonstrate similar refractive accuracy across all ALs. Short eyes pose the greatest challenge to predicting postoperative refractive error. | Kevin S Tang Elaine M Tran Allison J Chen David R Rivera Jorge J Rivera Paul B Greenberg | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 3 | Charge transport along the λ- DNA显示文摘 | Tran P Alavi B Gruner G | 2000 | Phys Rev Lett2000，85，： | 1 |
| 4 | Distribution andgenetic diversity of lactic acid bacteria from traditional fermentedsausage显示文摘 | TRAN KTM MAY B E SMOOKER P M et ai | 2011 | Food Research International2011，44，1： | 1 |
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| 7 | Production of anti-Müllerian hormone:another homology between Sertoli and granulosa cells显示文摘 | Vigier B Picard JY Tran D | 1984 | Endocrinology1984，114，： | 1 |
| 8 | Review of piezodialysis- salt removal with charge mosaic membranes显示文摘 | Bolto B Hoang M Tran T | 2010 | Desali- nation2010，254，： | 1 |
| 9 | Syphilitic uveitis in pa- tients infected with human immunodeficiency virus显示文摘 | Tran TH Cassoux N Bodaghi B | 2005 | Graefes Arch Clin Exp Ophthalmol2005，243，： | 1 |
| 10 | Transmembrane TNF is sufficient to initiate cell migration and granuloma formation and provide acute, but not long-term, control of Myeobacterium tuberculosis infection显示文摘 | Saunders B M Tran S Ruuls S | 2005 | J Immunol2005，174，8： | 1 |
| 11 | Automated,quantitative screening assay for antiangiogenic compounds using transgenic zebrafish显示文摘 | Tran T C Sneed B Haider J | 2007 | Cancer Res2007，67，11： | 1 |
| 12 | Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues 显示文摘 | Waltregny D De Leval L Glenisson W Ly Tran S North B J Bellahcfine A | 2004 | Am J Pathol2004，165，： | 1 |
| 13 | Wavelength-spacing tunable muhiwavelength erbium-doped fiber laser based on four-wave mixing of dispersion-shifted fiber 显示文摘 | Han Y G Tran T V A Lee S B | 2006 | Optics Letters2006，31，6： | 1 |
| 14 | Directwrite piezoelectric polymetric nanogenerator with high energy conversion efficiency显示文摘 | CHANG C TRAN V H WANG J B | 2011 | Nano Lett2011，10，2： | 1 |
| 15 | Grain growth, phase evolution and properties of NbC carbide-doped WC-10AISI304 hardmetals produced by pseudo hot isostatic pressing显示文摘 | TRAN B T ZUHAILAWATI H AHMAD Z A ISHIHARA K N | 2012 | Journal of Alloys and Compounds2012，552，： | 1 |
| 16 | Histone deacetylase HDAC8 associates with smooth muscle alpha actin and is essential for smooth muscle cell con tractility显示文摘 | Waltregny D Glenisson W Tran S L North B J Verdin E Coli ge A | 2005 | Faseb J2005，19，： | 1 |
| 17 | The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors显示文摘 | BELMADANI A TRAN P B REN D | 2005 | J Neurosci2005，25，： | 1 |
| 18 | Syphilitic uveitis in pa- tients infected with human immunodeficiency virus显示文摘 | Tran TH Cassoux N Bodaghi B | 2005 | Graefes Arch Clin Exp Ophthalmol2005，243，： | 1 |
| 19 | Hybrid approa ches to repair oI' complex aortic aneurysmal disease显示文摘 | Starnes B W Tran N T McDonald J M | 2007 | Sur Clin North Am2007，87，10： | 1 |
| 20 | Luminal-B breast cancer and novel therapeutic targets显示文摘 | Tran B Bedard PL | 2011 | Breast Cancer Res2011，13，6： | 1 |
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