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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 3 | Characterization of diamond-like carbon by raman spectroscopy,XPS and optical constants 显示文摘 | Mossner C Grant P Tran H | 1998 | Thin Solid Films1998，317，： | 1 |
| 4 | Near-Infrared Spectroscopic Investigation of Inclusion Complexes Between Cyclodextrinsand Aromatic Compounds 显示文摘 | Politi M J’Tran C D Gao G H | 1995 | J Phys Chem1995，99，14： | 1 |
| 5 | Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc显示文摘 | Tran C M Markova D Smith H E | 2010 | Arthritis Rheum2010，62，7： | 1 |
| 6 | Electrosorptinn of inorganic salt from aqueous solution using carbon aerogeI electrodes显示文摘 | Gabelich C J Tran T D Suffet I H | 2002 | EnvironSciTech2002，36，： | 1 |
| 7 | Determination of Binding Constants of Cyclodextrins in Room-temperature Ionic Liquids byNear-infrared Spectrometry显示文摘 | Tran C D Lacerda S H D P | 2002 | Anal Chem2002，74，： | 1 |
| 8 | Directwrite piezoelectric polymetric nanogenerator with high energy conversion efficiency显示文摘 | CHANG C TRAN V H WANG J B | 2011 | Nano Lett2011，10，2： | 1 |
| 9 | Fingerprinting microbial assemblages from the oxic/anoxic chemocline of the Black Sea 显示文摘 | Vetriani C Tran H V Kerkhof L J | 2003 | Applied and Environmental Microbiology2003，69，11： | 1 |
| 10 | Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002-2003 显示文摘 | Druce J Tran T Kelly H Kaye M Chibo D Kostecki R Amiri A Catton M Birch C | 2005 | J Med Virol2005，75，1： | 1 |
| 11 | Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17,T(H)1 and T(H)2 cells显示文摘 | Trifari S Kaplan C D Tran E H | 2009 | Nat Immunol2009，10，8： | 1 |
| 12 | Data reduction of room tests for zone model validation 显示文摘 | Janssens M L Tran H C | 1992 | Journal of Fire Sci- ence1992，10，6： | 1 |
| 13 | Clinical and pharmacokinetic study of TNP-470,an angiogenesis inhibitor,in combination with paclitaxel and carboplatin in patients with solid tumors显示文摘 | TRAN H T BLUMENSCHEIN G R LU C | 2004 | Cancer Chemother Pharmacol2004，54，4： | 1 |
| 14 | Metabolic adaptations of phosphate- starved plants显示文摘 | Plaxton W C Tran H T | 2011 | Plant Physiology2011，156，3： | 1 |
| 15 | A prospective, ran- domized comparison between single-and double-injection, ul trasound guided supraelavicular brachial plexus block显示文摘 | Tran de Q H Mufioz L Zaouter C | 2009 | Reg Anesth Pain Med2009，34，5： | 1 |
| 16 | Analysis of laminated composite plates using higher-order shear deformation plate theory and node-based smoothed discrete shear gap method 显示文摘 | THAI C H TRAN L V TRAN D T NGUYEN-THOI T NGUYEN- XUAN H | 2012 | Applied Mathematical Modelling2012，36，11： | 1 |
| 17 | Angle closure: classification, concepts, and the role of ultrasound biomicroscopy in diagnosis and treatment显示文摘 | Tello C Tran H V Liebmann J | 2002 | Semin Ophthalmol2002，17，： | 1 |
| 18 | Health benefits of probiotics for the elderly:a review显示文摘 | BAKER H C TRAN D N THOMAS L V | 2009 | Journal of Food Service2009，20，5： | 1 |
| 19 | Analysis of functionally graded plates by an efficient finite element method with node-based strain smoothing 显示文摘 | NGUYEN-XUAN H TRAN L V THAI C H NGUYEN-THOI T | 2012 | Thin-Walled Structures2012，54，： | 1 |
| 20 | Burning rate of solid wood meas- ured in a heat release rate calorimeter 显示文摘 | Tran H C White R H | 1992 | Fire and Ma- terials1992，16，： | 1 |
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