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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | on the Deep Drawing of Cups with Punch and Blank-Holding Forces Proportional to a Hydraulic Pressure显示文摘 | Thiruvarudchelvan S Travis F W Poh T K | 1999 | Journal of Materials Processing Technology1999，9293，1： | 1 |
| 3 | On the deep drawing of cups with punch and blank-holder forces proportional to a hydraulic pressure显示文摘 | Thiruvarudchelvan S Travis F W | 1999 | Journal of Materials Processing Technology1999，88，： | 1 |
| 4 | Hydraulic pressure-enhanced cup-drawing processes-an appraisal显示文摘 | THIRUVARUDCHELVAN S TRAVIS F W | 2003 | Journal of Materials Processing Technology2003，140，： | 1 |
| 5 | Hydraulic pressure-enhanced cup drawing processes--an appraisal显示文摘 | Thiruvarudchelvan S Travis F W | 2003 | Journal of Materials Processing Technology2003，140，13： | 1 |
| 6 | On the deep drawing of cups with punch and blank-holder forces proportional to a hydraulic pressure 显示文摘 | Thiruvarudchelvan S Travis F W Poh T K | 1999 | Journal of Materials Processing Technology1999，92，： | 1 |
| 7 | Pyrolysis behavior and kinetics of biomass derived materials显示文摘 | Travis F Mohammad H Bruce W | 2002 | Journal of Analytical and Applied Pyrolysis2002，62，2： | 1 |
| 8 | Hydraulic-pressure-enhanced cup-&awing processes-an appraisal 显示文摘 | Thiruvarudchelvan S Travis F W | 2003 | Journal of Materials Processing Technology2003，140，： | 1 |
| 9 | Pyrolysis behavior and kinetics of biomass derived materials显示文摘 | TRAVIS F MOHAMMAD H BRUCE W | 2002 | Journal of Analytical and Applied Pyrolysis2002，62，： | 1 |
| 10 | On the Deep Drawing of Cups with Punch and Blank-holding Forces Proportional to a Hydraulic Pressure显示文摘 | Thiruvarudchelvan S Travis F W Poh T K | 1999 | Journal of Materials Processing Technology1999，9293，： | 1 |
| 11 | T h e annualreproductive cycle of m ink (Mustela v is o n )显示文摘 | Pilbeam T E Concannon P W Travis H F | 1979 | J A nim S c i1979，48，3： | 1 |
| 12 | On the deep drawing of cups with punch and blank-holder forces proportional to a hydraulic pressure 显示文摘 | Thiruvarudchelvan S Travis F W | 1999 | Journal of Materials Processing Technology1999，88，： | 1 |
| 13 | Control of luteal function and implantation in the mink by prolactin 显示文摘 | Papke R L Concannon P W Travis H F | 1980 | J Anita Sci1980，50，： | 1 |
| 14 | Prolactin: the hypophy- seal factor that terminates embryonic diapause in mink 显示文摘 | Murphy B D Concannon P W Travis H F | 1981 | Biol Reprod1981，25，： | 1 |
| 15 | A study of the interactive effects of strain, strain rate and temperature in severe plastic deformation of copper显示文摘 | TRAVIS L B CHRISTOPHER S TEJAS G M JAMES B M YANG G LARRY F A ALEXANDER H K DALE C W KEVIN P T SRINIVASAN C | 2009 | Acta Materialia2009，57，18： | 1 |
| 16 | Hydraufic-pressure-enhanced cup-drawing proeesses-an appraisal显示文摘 | THIRUVARUDCHELVAN S TRAVIS F W | 2003 | Journal of Materials Processing Technology2003，140，13： | 1 |
| 17 | High-speed cratering in wax and plasticine显示文摘 | Johnson W Travis F W | 1968 | International Journal of Mechanical Sci- ences1968，10，： | 1 |
| 18 | High-speed impact of plasticine projectiles with laminated plasticine targets显示文摘 | Carrel J Johnson W Travis F W | 1968 | International Journal of Mechanical Sciences1968，10，： | 1 |
| 19 | Seasonal nitrogen concentration,uptake,and partitioning pattern of irrigated acala and pima cotton as influenced by nitrogen fertility level显示文摘 | FRITSCHI F B ROBERTS B A TRAVIS R L RAINS D W HUTMACHER R B | 2004 | Crop Science2004，44，： | 1 |
| 20 | Pleomorphic (spindle/giant cell)carcinoma of the lung:A clinicopathologic correlation of 78 cases显示文摘 | Fishbake N F Travis W D Moran C A | 1994 | Cancer1994，73，15： | 1 |
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