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| 1 | Inflammation and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C显示文摘At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and mortality.Injury to the liver,the largest solid organ in the body,leads to a cascade of inflammatory events.Chronic inflammation leads to the activation of hepatic stellate cells that undergo transdifferentiation to become myofibroblasts,the main extra-cellular matrix producing cells in the liver;over time increased extra-cellular matrix production results in the formation of liver fibrosis.Although fibrogenesis may be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can become pathogenic culminating in CLD,cirrhosis and its associated complications.As the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated morbidity,the diagnostic assessment of CLD by non-invasive testing is attractive.Accordingly,in this review the mechanisms by which liver inflammation and fibrosis develop in chronic liver diseases are explored to identify appropriate and meaningful diagnostic targets for clinical practice.Due to differing disease prevalence and treatment efficacy,disease specific diagnostic targets are required to optimally manage individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C infection.To facilitate this,a review of the pathogenesis of both conditions is also conducted.Finally,the evidence for hepatic fibrosis regression and the mechanisms by which this occurs are discussed,including the current use of antifibrotic therapy. | Sudeep Tanwar Freya Rhodes Ankur Srivastava Paul M Trembling William M Rosenberg | 2020 | World Journal of Gastroenterology2020，26，2： | 17 |
| 2 | Treatment of complex fractures wrist fractures 显示文摘 | HANEL D P JONES M D TREMBLE T E | 2002 | Orthop Clin of North Am2002，33，1： | 1 |
| 3 | Wrist fractures 显示文摘 | Hanel DP Jones MD Tremble TE | 2002 | Orthop Clin North Am2002，33，1： | 1 |
| 4 | Could cryogenics crystallize as an option for sand reclamation? 显示文摘 | Tordoff W L Miller J Trembly J | 1998 | Modern Casting1998，88，8： | 1 |
| 5 | Cocktails Tb3+and Eu3+complexes:ageneral platform for the design of ratiometric optical probes显示文摘 | Trembly M S Halim M Sames D | 2007 | J Am Chem Soc2007，129，24： | 1 |
| 6 | Treatment of complex fractures wrist fractures显示文摘 | Hanel DP Jones MD Tremble TE | 2002 | Orthop Clin of North Am2002，33，1： | 1 |
| 7 | Increased resistance to CD4 +CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes显示文摘 | Lawson JM Tremble J Dayan C | | 0，，03： | 1 |
| 8 | Wrist fractures显示文摘 | Hand DP Jones MD Tremble TE | | 0，，： | 1 |
| 9 | Factom dtem-ing,fIlnctionclou ome of displaced infra-air_cular dist~mdinsfractures显示文摘 | TREMBLE TE HMIT SR V DER NB | 2011 | J Hand surg(Am)2011，325，3： | 1 |
| 10 | Treatm ent of Complex Fractures Wrist Frac-tures显示文摘 | Hanel D P Jones M D Tremble T E | 2002 | Orthop Clin of North Am2002，33，1： | 1 |
| 11 | Modeling a 5 kWe planar solid oxide fuel cell based system operating on JP-8 fuel and a comparison with tubular cell based system for auxiliary and mobile power applications显示文摘 | TANIM T BAYLESS D J TREMBLY J P | 2014 | Journal of Power Sources2014，245，： | 1 |
| 12 | Modeling of a 5 kWe tubular solid oxide fuel cell based system operating on desulfurized JP-8 fuel for auxiliary and mobile power applications显示文摘 | TANIM T BAYLESS D J TREMBLY J P | 2013 | Journal of Power Sources2013，221，： | 1 |
| 13 | Role of Racl and oxygen radicals in eollagenase - 1 expression induced by cell shape change 显示文摘 | Kheradmand F Wemer E Tremble P | 1998 | Science1998，280，5365： | 1 |
| 14 | Treatment of complex fractures,wristfractures显示文摘 | Hand D Jones MD Tremble TE | 2002 | Orthopedic Clilnics of North hlxlerica2002，33，1： | 1 |
| 15 | Cushing's syndrome associated with a chemodectoma and a carcinoid tumour 显示文摘 | Tremble JM Buxtun-Thomas M Hopkins D | 2000 | Clin Endocrinol2000，52，： | 1 |
| 16 | Wrist fractures显示文摘 | Hanel DP Jones MD Tremble TE | 2002 | Orthop Clin North Am2002，33，1： | 1 |
| 17 | Is continued weight gain inevitable in type 2 diabetes mellitus? 显示文摘 | Tremble J M Donaldson D | 1999 | J R Soc Health1999，119，： | 1 |
| 18 | Wrist fractures显示文摘 | Hanel DP Jones MD Tremble TE | 2002 | Orthop Clin North Am2002，33，1： | 1 |
| 19 | Treatment of complex frac tures, wrist fractures 显示文摘 | Hanel DP Jones MD Tremble TE | 2002 | Orthop Clin of North Am2002，33，1： | 1 |
| 20 | A theoretical model for input impedance of interstitial microwave antennas with choke显示文摘 | Wong T Z Trembly B S | 1994 | International Journal Of Radiation Oncology Biology Physics1994，28，3： | 1 |
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