|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Autoantibodies against G-Protein-Coupled Receptors Modulate Heart Mast Cells显示文摘Mast cells are believed to be involved in myocardial tissue remodelling under pathophysiological conditions. We examined the effects of autoantibodies against G-protein-coupled receptors in sera of patients with heart diseases on myocardial mast cells in the cultured neonatal Sprague-Dawley rat heart cells. Cells collected at day 3 and 10 of the culture were preincubated with autoantibodies against α1-adrenoceptor and angiotensin II AT1-receptor, agonist phenylephrine and angiotensin II, and control IgG. The pretreated cultured cells were stained for selected mast cell markers tryptase, chymase and TNF-α. The cultured cells were also processed for observation with electron microscopy. The autoantibodies-treatment of the 3-day cultured cells caused both increased intensity of immunofluorescence (p < 0.05) and their enlarged diameters of the mast cells when compared to age-matched ones. In contrast, the fluorescence of preincubated 10-day-old mast cells was decreased compared with controls (p < 0.01). In control samples, the fluorescence of 10-day-old mast cells was significantly higher than that of 3-day-old ones (p < 0.001). Results of electron microscopy examination demonstrated there was an increased granulation of treated 3-day-old mast cells, while a degranulation of mast cells at day 10 of application. The results suggest the modulation effect of the autoantibodies against G-protein-coupled receptors on mast cells, indicating a potential functional link between the autoantibodies against G-protein-coupled receptors and the mast cells in progression of heart disease. | Ludmila Okruhlicova Rosemarie Morwinski Wolfgang Schulze Sabine Bartel Peter Weismann Narcisa Tribulova Gerd Wallukat | 2007 | Cellular & Molecular Immunology2007，4，2： | 6 |
| 2 | Dispersion of cell-to-cell uncoupling precedes low K^+ -induced ventricular fibrillation 显示文摘 | Tribulova N Manoach M Varon D | 2001 | Physiol Res2001，50，3： | 1 |
| 3 | Brief,intermediate and prolonged ischemia in the isolated crystalloid perfusod rat heart:relationship between susceptibility to arrhythmias and degre of ultrastruetural injury显示文摘 | Ravingerova T Tribulova N Slezak J | 1995 | J Mol Cell Cardiol1995，27，9： | 1 |
| 4 | Brief, intermediate and Ira)longed ischemia in the isolated crystalloid perfused rat heart: rela- tionship between susceptibility to arrhythmias and degree of ultrastrue- rural injury 显示文摘 | Ravingerova T Tribulova N Slezak J | 1995 | J Mol Cell Cardiut1995，27，9： | 1 |
| 5 | Gap junction remodelling is involved in the susceptibility of diabetic rats tohypokalemia-induced ventricular fibrillation 显示文摘 | Okruhlicova L Tribulova N Misejkova M | 2002 | Acta Histochem2002，104，4： | 1 |
| 6 | Free oxygen radicals contribute to high incidence of reperfusion induced arrhythmias in isolated rat heart 显示文摘 | Ravingerova T Slezak J Tribulova N | 1999 | Life Sci1999，65，1819： | 1 |
| 7 | Hibernating myocardium:pathophysiology,diagnosis,and treatment显示文摘 | Slezak J Tribulova N Dkruhlicova L | 2009 | Can J Physiol Pharmacol2009，87，4： | 1 |
| 8 | Aged heart as a model for prolonged atrial fibrilloflutter显示文摘 | Tribulova N Varon D Polak-Charon S | | 0，，： | 1 |
| 9 | Gap junction remodelling is involved in the susceptibility of diabetic rats to hypokalemia-induced ventricular fibrillation 显示文摘 | Okruhlicova L Tribulova N Misejkova M | 2002 | Acta Histochem2002，104，4： | 1 |
| 10 | Brief, intermediate and prolonged ischemia in the isolated crystalloid perfused rat heart: relationship between susceptibility to arrhythmias and degree of ultrastructural injury显示文摘 | Ravingerova T Tribulova N Slezak J | 1995 | J Mol Cell Cardiol1995，27，9： | 1 |
| 11 | Brief, intermediate and prolonged isehemia in the isolated crystalloid perfused rat heart: relationship between susceptibility to arrhythmias and degree of uhrastruetural injury显示文摘 | Ravingerova T Tribulova N Slezak J | 1995 | J Mol Cell Cardiol1995，27，9： | 1 |
| 12 | Induction of angiogenesis in NO-deficient rat heart 显示文摘 | Okruhlioova L Tribulova N Bernalova I | 2000 | Physiol Res2000，49，1： | 1 |
| 13 | Hypokalemia-induced ultrastructural, histochemical and connexin-43 alternations resulting in atrial and ventricular fibrillation 显示文摘 | Tribulova N Manoach M Varon D | 1999 | Gen Physiol Biopyhs1999，18，1： | 1 |
| 14 | Brief, intermediate and prolonged isehemia in the isolated erystalloid perfused rat heart: relationship between susceptibility to arrhythmias and degree of uhrastruetural injury 显示文摘 | Ravingemva T Tribulova N Slezak J | 1995 | J Mol Cell Cardiol1995，27，9： | 1 |
| 15 | Myocardial gap junctions :Targets for novel approaches in the prevention of life - threatening cardiac arrhythmias 显示文摘 | Tribulova N Knezl V Okruhlicova L | 2008 | Physiol Res2008，57，： | 1 |
| 16 | Dispersion of cell-to-cell uncoupling precede low K^+ -induced ventricular fibrillation 显示文摘 | Tribulova N Manoach M Varon D | 2001 | Physiol Res2001，50，3： | 1 |
| 17 | Induction of angiogenesis in NO-deficient rat heart 显示文摘 | Okruhlioova L Tribulova N Bemalova I Pechanova O | 2000 | Physiol Res2000，49，1： | 1 |
| 18 | Hypertension-related intermyocyte junction remodeling is associated with a high incidence of low- K^+ -induced lethal arrhythmias in isolated rat heart 显示文摘 | Tribulova N Okruhlicova L Novakova S | 2002 | Exp Physiol2002，87，2： | 1 |
| 19 | Brief, intermediate and prolonged ischemia in the isolated crystalloid perfused rat heart: relationship between susceptibility to arrhythmias and degree of ultrastructurat injury 显示文摘 | RAVINGEROVA T TRIBULOVA N SLEZAK J et at | 1995 | J Mol Cell Cardiol1995，27，9： | 1 |
| 20 | Brief,intermediate and prolonged ischemia in the isolated crystalloid perfused rat heart:relationship between susceptibility to arrhythmias and degree of ultrastructural injury显示文摘 | Ravingerova T Tribulova N Slezak J | 1995 | J Mol Cell Cardiol1995，27，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员