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| 1 | Updated therapeutic outcome for patients with periampullary and pancreatic cancer related to recent translational research显示文摘Chemotherapy with improved effect in patients with metastatic pancreatic cancer has recently been established, launching a new era for patients with this very aggressive disease. FOLFIRINOX and gemcitabine plus nab-paclitaxel are different regimens, both capable of stabilizing the disease, thus increasing the number of patients who can reach second line and even third line of treatment. Concurrently, new windows of opportunity open for nutritional support and other therapeutic interventions, improving quality of life. Also pancreatic surgery has changed significantly during the latest years. Extended operations, including vascular/multivisceral resections are frequently performed in specialized centers, pushing borders of resectability. Potentially curative treatment including neoadjuvant and adjuvant chemotherapy is offered new patient groups. Translational research is the basis for the essential understanding of the ongoing development. Even thou biomarkers for clinical management of patients with periampullary tumors have almost been lacking, biomarker driven trials are now in progress. New insight is constantly made available for clinicians; one recent example is selection of patients for gemcitabine treatment based on the expression level of the human equilibrium nucleoside transporter 1. An example of new diagnostic tools is identification of early pancreatic cancer patients by a three-biomarker panel in urine: The proteins lymphatic vessel endothelial hyaluronan receptor 1, regenerating gene 1 alpha and translation elongation factor 1 alpha. Requirement of treatment guideline revisions is intensifying, as combined chemotherapy regimens result in unexpected advantages. The European Study Group for Pancreatic Cancer 4 trial outcome is an illustration: Addition of capecitabine in the adjuvant setting improved overall survival more than expected from the effect in advanced disease. Rapid implementation of new treatment options is mandatory when progress finally extends to patients with this serious disease. | Trond A Buanes | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 2 | Role of surgery in pancreatic cancer显示文摘Treatment of pancreatic cancer is multimodal and surgery is an essential part,mandatory for curative potential.Also chemotherapy is essential,and serious postoperative complications or rapid disease progression may preclude completion of multimodal treatment.The sequence of treatment interventions has therefore become an important concern,and numerous ongoing randomized controlled trials compare clinical outcome after upfront surgery and neoadjuvant treatment with subsequent resection.In previous years,borderline resectable and locally advanced pancreatic cancer was most often considered unresectable.More effective chemotherapy together with the latest improvements in surgical expertise has resulted in extended operations,pushing the borders of resectability.Multivisceral resections with or without resection of major mesen-teric vessels are now performed in numerous patients,resulting in better outcome,recorded as overall survival and/or patient reported outcome.But postoperative morbidity increases concurrently,and clinical benefit must be carefully evaluated against risk of potential harm,associated with new comprehensive multimodal treatment sequences.Even though cost/utility analyses are deficient,extended surgery has resulted in signifi-cantly longer and better life for many patients with no other treatment alternative.Improved selection of patients to surgery and/or chemotherapy will in the near future be possible,based on better tumor biology insight.Clinically available biomarkers enabling personalized treatment are forthcoming,but these options are still limited.The importance of surgical resection for each patient’s prognosis is presently increasing,justifying sustained expansion of the surgical treatment modality. | Trond A Buanes | 2017 | World Journal of Gastroenterology2017，23，21： | 2 |
| 3 | Limited intertemporal commitment and job design 显示文摘 | Meyer M A Trond E Gaute T | 1996 | Journal of Economic Behavior & Organization1996，31，： | 1 |
| 4 | The effects of moderate ozonation or high intensity UV-irradiation on the microbial environment in RAS for marine larvae 显示文摘 | KARl J K A GUNVOR O TROND R S | 2012 | Aquaculture2012，，： | 1 |
| 5 | Carbon mineralization,fungal and bacterial growth,and enzyme activities as affected by contact between crop residues and soil 显示文摘 | Trond M Henriksen Tor A | 2002 | Biology and Fertility of Soils2002，35，1： | 1 |
| 6 | The Value of ultrasound in predicting autoimmune thyroid disease 显示文摘 | Ole M P Niles P A Trond B L | 2000 | Thyroid2000，10，3： | 1 |
| 7 | Generation of induced pluripotent stem eells from human cord blood using OCT4 and SOX2显示文摘 | ALESSANDRA G NURIA M TROND A | 2009 | Cell Stem Cell2009，5，： | 1 |
| 8 | Regional differences in bioavailability of an opioid tetrapeptide in vivo in rats after administration to the respiratory tract 显示文摘 | Krondahl E Tronde A Eirefelt S Forsmo-Bruced H | 2002 | Peptides2002，23，： | 1 |
| 9 | Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors:comparison with recombi- nant human 5-HT4 splice variants显示文摘 | Kurt A Krobert Trond Brattehd Finn Olav Levy | 2005 | Naunyn-Schmiedeberg'' s Arch Pharmacol2005，371，6： | 1 |
| 10 | Carbon mineralization, fungal and bacterial growth, and enzyme activities as affected by contact be- tween crop residues and soil显示文摘 | Trond M Hem'iksen Tor A Breland | 2002 | Biology and Fertility of Soils2002，35，： | 1 |
| 11 | Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes显示文摘 | Trond A Angel R Maria JB | 2008 | Nat Bio-technol2008，26，11： | 1 |
| 12 | Carbon mineralization, fungal and bacterial growth, and enzyme activities as affected by contact between crop residues and soil显示文摘 | Trond M Henriksen Tor A Breland | 2002 | Biology and Fertility of Soils2002，35，1： | 1 |
| 13 | An ExperimentalInvestigation of Scrubber Internals at Conditions of LowPressure显示文摘 | Trond A Lars H Gjertsen A | 2008 | Chemical Engineering Journal2008，138，1： | 1 |
| 14 | Methodologies to increase the transformation efficiencies and the range of bacteria that can be trans- formed 显示文摘 | TROND E V A FINN L A | 2010 | Appl Microbiol Biotechnol2010，85，5： | 1 |
| 15 | Cloning,pharmacological characterisation and tissue distri- bution of a novel 5-HT4 receptor splice variant,5-HT4 (i) 显示文摘 | Trond Brattelid Ane M Kvingedal Kurt A Krobert | 2004 | Naunyn-Sehmiedeberg''s Arch Ph armaeol2004，369，6： | 1 |
| 16 | Mi-cropump based on electroosmosis of the second kind 显示文摘 | Nataliya A Mishchukl Trond Heldal Tormod Volden | 2009 | E-lectrophoresis2009，30，20： | 1 |
| 17 | 肠道病毒作为乳糜泻的触发因素:在前瞻性出生队列中进行的巢式病例对照研究显示文摘目的确定感染人肠道病毒或腺病毒(均为常见的肠道病毒)是否可作为乳糜泻的预测因素。设计在挪威出生队列中纳入2001至2007年新生儿的巢式病例对照研究,随访至2016年9月。背景挪威人群。参与者携带HLA DR4-DQ8/DR3-DQ2基因型(增加患乳糜泻风险)的儿童。暴露因素采集3~36个月儿童每个月的粪便样本,并且用实时聚合酶链式反应检测其中的肠道病毒和腺病毒。主要结局测量根据乳糜泻的诊断标准诊断乳糜泻。分别在3,6,9和12个月时采集血样并检测乳糜泻抗体,之后每年检测一次。采用混合效应Logistic回归模型得到的调整后的比值比,来评估出现乳糜泻抗体前的病毒感染与乳糜泻之间的关系。结果在220名儿童中,平均9.9年(标准差为1.6)后,25名儿童在筛查后被诊断为乳糜泻,且每名患儿分别与两名对照组儿童进行配对。在2 135个样本中共有370个(17%)发现了肠道病毒,并且乳糜泻患者出现乳糜泻抗体前收集的样本肠道病毒阳性率显著高于对照组(调整后的比值比为1.49,95%可信区间为1.07-2.06;P=0.02)o这种关联仅限于引入鉄质后的感染。样本病毒拷贝数越多(>100 000拷贝/以)(调整后比值比为2.11,1.24-3.60;P=0.01)和长时间感染(>2个月)(2.16,1.16-4.04;P=0.02)具有更高的风险。通常检测到的肠道病毒A和肠道病毒B均与乳糜泻显著相关。在出现乳糜泻抗体期间或之后没有发现与感染的关联。腺病毒感染与乳糜泻无关。结论在这项纵向研究中,儿童早期肠道病毒的高检出率与后期乳糜泻的发生有关,而腺病毒的高检出率与乳糜泻无关。这个发现补充说明了病毒感染在乳糜泻病因学中的作用。 | Christian R Kahrs Katerina Chuda German Tapia Lars C Stene Karl Marild Trond Rasmussen Kjersti S Ronningen Knut E A Lundin Lenka Kramna Ondrej Cinek Ketil Stordal 柳思华(译) 吴东(校) | 2019 | 英国医学杂志中文版2019，22，7： | 1 |
| 18 | Limited intertemporal commitment and job design 显示文摘 | Meyer M A Trond E Gaute T | 1996 | Journal of Economic Behavior & Organization1996，31，： | 1 |
| 19 | Nonleaching Antimicrobial Films Prepared from Surface-Modified Microfibrillated Cellulose 显示文摘 | Martin A Per S Trond M | 2007 | Biomacromolecules2007，8，： | 1 |
| 20 | The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitre model of HPV-16-associated cervical cancer progression 显示文摘 | Trond A Malcolm BH Michael E | 2003 | Oncogene2003，22，39： | 1 |
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