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| 1 | Evaluating causal relations in neural systems: Granger causality, directed transfer function and statistical assessment of significance显示文摘 | Maciej Kamiński Mingzhou Ding Wilson A. Truccolo Steven L. Bressler | 2001 | Biological Cybernetics2001，，2： | 3 |
| 2 | In vivo apoptosis of hepatocytes in guinea pigs infected with Leptospira interrogans serovar icterohaemorrhagiae显示文摘 | MERIEN F TRUCCOLO J ROUGIER Y | 1998 | FEMS Microbiol Lett1998，169，： | 1 |
| 3 | Single-neuron dynam-ics in human focal epilepsy显示文摘 | Truccolo W Donoghue JA Hochberg LR | 2011 | Nat Neurosci2011，14，5： | 1 |
| 4 | Hetero geneous neuronal firing patterns during interictalepileptiform discharges in the human cortex显示文摘 | Keller CJ Truccolo W Gale JT Eskandar E Thesen T CarlsonC | 2010 | Brain2010，133，6： | 1 |
| 5 | Evaluating causal rela- tions in neural systems: granger causality, directed transfer function and statistical assessment of significance显示文摘 | Kaminski M Ding M Truccolo WA | 2001 | Biol Cybern2001，85，2： | 1 |
| 6 | Evaluating causal relations in neural systems: granger causality, directed transfer function and statistical assessment of significance显示文摘 | Kaminski M Ding M Truccolo WA | 2001 | BioI Cybern2001，85，2： | 1 |
| 7 | Evaluating causal relations in neural systems: Granger causality, directed transfer func- tion and statistical assessment of significance显示文摘 | KAMINSKI M DING Z TRUCCOLO W | 2001 | Biological Cyber- netics2001，85，2： | 1 |
| 8 | Evaluating causal relations in neural systems:granger causality,directed transfer function and statistical assessment of significance显示文摘 | Kaminski M Ding M Truccolo W A | 2001 | Biol Cybern2001，85，2： | 1 |
| 9 | Trial-to- trial variability of cortical evoked responses: implications for the analysis of functional connectivity显示文摘 | TRUCCOLO W A DING M KNUTH K H | 2002 | Clin Neurophysiol2002，113，2： | 1 |
| 10 | 有机微量元素作为环境污染解决方案的综述显示文摘铜和锌这两种微量元素参与生物体重要的代谢反应,也是多种酶和生物分子的主要成分。锌和铜通常以无机盐形式添加到动物日粮中,但它们的吸收率和生物利用率较低,同时添加微量元素时污染物的存在也是一个主要考虑的因素。例如,动物饲料中常用的氧化锌和硫酸铜通常来自钢铁工业的残留物,因此可能潜在携带高水平的污染物,如镉和氟。市场法规对肉品生产的要求日益严格,并加大了对动物饲料中重金属和其他污染物的限制力度。 | 张江(译) 潘雪男(审) Marcos Milani TRUCCOLO | 2017 | 国外畜牧学(猪与禽)2017，0，4： | 1 |
| 11 | Single-neuron dynamics in human focal epilepsy显示文摘 | TRUCCOLO W DONOGHUE J A HOCHBERG L R | 2011 | Nat Neurosci2011，14，5： | 1 |
| 12 | Evaluating causal relations in neural systems: Granger causality, directed transfer function and statistical assessment of significance显示文摘 | Maciej Kamiński Mingzhou Ding Wilson A. Truccolo Steven L. Bressler | 2001 | Biological Cybernetics2001，，2： | 1 |
| 13 | TriM-to-trial variability of conical evoked responses: Implications for the analysis of functional eonnectivity显示文摘 | Truccolo WA Ding M Knuth KH | 2002 | Clin Neurophysiol2002，113，2： | 1 |
| 14 | Trial-to-trial variability of cortical evoked responses: Implications for the analysis of functional connectivity 显示文摘 | Truccolo WA Ding MZ Knuth KH | 2002 | Clin Neurophysiol2002，113，： | 1 |
| 15 | Single - neuron dynamics in human focal epilepsy显示文摘 | Truccolo W Donoghue JA Hochberg LR | 2011 | Nat Neurosci2011，14，5： | 1 |
| 16 | Evaluating causal relations in neural systems:Granger causality,directed transfer function and statistical assessment of significance显示文摘 | KAMINSKI M DING Z TRUCCOLO W | 2001 | Biological Cybernetics2001，85，： | 1 |
| 17 | Trial-to-trial variability of cortical evoked responses: implications for the analysis of functional Connectivity 显示文摘 | Truccolo WA Ding M Knuth KH | 2002 | Clin Neurophysiol2002，113，2： | 1 |
| 18 | Heterogeneous neuronal fir- ing patterns during interictal epileptiform discharges in the human cortex显示文摘 | Keller CJ Truccolo W Gale JT | 2010 | Brain2010，133，： | 1 |
| 19 | Trial-to-trial variability of cortical evoked responses:implications for the analysis of functional connectivity显示文摘 | Truccolo WA Ding MZ Knuth KH | 2002 | Clin Neurophysio12002，113，： | 1 |
| 20 | Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease显示文摘BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in animals.METHODS Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were obtained.RESULTS All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop HCC.Comparing animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the HCC-group.The opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-protein.Comparing with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(P<0.05).Carm1 was lower in HCC compared to RIF(P<0.05).Hepatic expression of Mmp9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm1(P<0.05).Expression of p62/SQSTM1 protein was lower in the RIF-group compared to the control(P=0.024).There was no difference among groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and Mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(P<0.05).miR-26b was lower in HCC compared to RIF,and the inverse was observed for miR-224(P<0.05).There was no difference among groups regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(P>0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis through epigenetic modulation in a rat model of MASLD-HCC. | Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva | 2024 | World Journal of Hepatology2024，16，1： | 0 |
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