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| 1 | TNF-α gene polymorphisms: association with age-related macular degeneration in Russian population显示文摘AIM: To study polymorphisms in promotor regions of tumor necrosis factor(TNF)-α TNF-863 A/C(rs1800630), TNF-308 A/G(rs1800629), and TNF-238 A/G(rs361525) in patients with age-related macular degeneration(AMD) and associations of complex TNF-α genotypes with AMD. METHODS: One hundred and two patients(82 women, 20 men; mean age 64.2±1.2 y) with AMD and 100 healthy age-and sex-matched controls(82 women, 18 men; 60±1.4 y) were included in the study. All subjects were Caucasian, all subjects and their parents were inhabitants of Russia. Genomic DNA was obtained from EDTA-preserved blood using the standard phenol-chloroform method. Polymorphisms were detected by polymerase chain reaction followed by the restriction fragment length polymorphism method. The following TNF-α genotypes were studied: TNF-α-238 AA, GA, GG, TNF-α-308 AA, GA, GG, TNF-α-863 AA, CA, CC. RESULTS: Differences in TNF-α-863 and TNF-α-238 genotypes frequencies in patients with AMD and healthy controls were not found. The distribution of TNF-α-308 AA and TNF-α-308 GA genotypes was significantly different between the studied group and the controls [odds ratios(OR) =0.22, P=0.0287 and OR=2.91, P=0.0063, respectively]. TNF-863 CC/TNF-308 GA and TNF-308 GA/TNF-238 GG genotypes were associated with the increased risk of AMD(OR=2.48, P=0.0332 and OR=2.51, P=0.0187, respectively). Five genotypes combinations appeared to be protective. CONCLUSION: In the present study, single nucleotide polymorphisms and complex polymorphisms of one of the key inflammatory cytokines TNF-α, and a number of significant associations of these polymorphisms with AMD in Russian population have been shown. Complexanalysis of genotypes could be important in AMD risk factors detection and studying pathogenesis. | Valeriy Chernykh Alla Shevchenko Vladimir Konenkov Viktor Prokofiev Alena Eremina Alexander Trunov | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 2 |
| 2 | Automated fault diagnosis in nonlinear multivariable systems using a learning methodology 显示文摘 | Trunov A B Polycarpou M M | 2000 | IEEE Transactions on Neural Networks2000，11，1： | 1 |
| 3 | Ig- nition of aluminum powders under different experimental conditions 显示文摘 | Mikhaylo A Trunov Mirko Schoenitz Edward L Dreizin | 2005 | Propellants Explosives Pyrotechnics2005，30，1： | 1 |
| 4 | Learning approach to nonlinear fault diagnosis: detectability analysis 显示文摘 | Polycarpou M M Trunov A B | 2000 | IEEE Transactions on Automatic Control2000，45，4： | 1 |
| 5 | Effect of polymorphic phase transformations in alumina layer on ignition of alumi- num particles 显示文摘 | Trunov M A Schoenitz M Dreizin E L | 2006 | Combustion Theory and Modeling2006，10，4： | 1 |
| 6 | Effect of poly- morphic phase transformations in A1203 film on oxida- tion kinetics of aluminum powders显示文摘 | Trunov M A Schoenitz M Zhu X | 2005 | Combustion and Flame2005，140，4： | 1 |
| 7 | Effect of poly- morphic phase transformations in alumina layer on ig- nition of aluminum particles显示文摘 | Trunov M A Schoenitz M Dreizin E L | 2006 | Combustion Theory' and Modeling2006，10，4： | 1 |
| 8 | Evaluation of ionic air purifiers for reducing aerosol exposure in confined indoor spaces 显示文摘 | Grinshpum SA Mainelis G Trunov M | 2005 | Indoor air2005，15，： | 1 |
| 9 | Automated fault diagnosis in nonlinear multivariable systems using a learning methodology 显示文摘 | Polycarpou M M | 2000 | IEEE Transactions on Neural Networks2000，11，1： | 1 |
| 10 | Learning Approach to Nonlinear Fault Diagnosis: Delectability Analysis 显示文摘 | POLYCATPOU M M TRUNOV A B | 2000 | IEEE Trans on Automatic Control2000，45，4： | 1 |
| 11 | Automated fault diagnosis in nonlinear multivariable systems using a learning methodology 显示文摘 | Trunov A B Polycarpou M M | 2000 | IEEE Trans Neural Networks2000，11，1： | 1 |
| 12 | Effect of polymorphic phase transformations in alumina layer on ignition of aluminum particles显示文摘 | Trunov M A Schoenitz M Dreizin E L | 2006 | Combustion Theory and Modeling2006，10，4： | 1 |
| 13 | Automated fault diagnosis in nonlinear multivariable systems using a learning methodology显示文摘 | POLYCARPOU M M | 2000 | IEEE Trans on Neural Network2000，11，1： | 1 |
| 14 | Automated fault diagnosis in nonlinear multivariable systems using a learning methodology显示文摘 | Trunov A B Polycarpou M | 2000 | IEEE Transactions on Neural Networks2000，11，1： | 1 |
| 15 | Ignition of alumi- num powders under different experimental conditions 显示文摘 | Trunov M A Schoenitz M Dreizin E L | 2005 | Propellants Explosives Pyrotechnics2005，30，1： | 1 |
| 16 | Learning Approach to Nonlinear Fault Diagnosis: Delectability Analysis 显示文摘 | POLYCARPOU M M TRUNOV A B | 2000 | IEEE Trans on Automatic Control2000，45，4： | 1 |
| 17 | Automated fault diagnosis in nonlinear multivariable systems using a learning methodology 显示文摘 | Trunov A B Polycarpou M M | 2000 | IEEE Transactions on Neural Networks2000，11，1： | 1 |
| 18 | Learning approach to fault diagnosis:delectability analysis显示文摘 | Polycarpou M Trunov A | | 0，，04： | 1 |
| 19 | Learning approach to nonlinear fault diagnosis: Detectability analysis显示文摘 | POLYCARPOU M M TRUNOV A B | 2000 | IEEE Transaction on automatic control2000，45，4： | 1 |
| 20 | Learning approach to nonlinear fault diagnosis:detectability analysis显示文摘 | Polycarpou M M Trunov A B | 2000 | IEEE Transactions on Automatic Control2000，45，4： | 1 |
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