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| 1 | Immune response to an indigenously developed r-Hepatitis B vaccine in mixed population: Study of an accelerated vaccination schedule显示文摘AIM: To establish the safety and efficacy of an indigenously developed r-hepatitis B vaccine using an accelerated schedule and to highlight the social awareness and commitment in preventing the spreading of hepatitis B virus infection.METHODS: The study was a multicentric, double blind,randomized (3:1) study using three doses of vaccine immunization schedule (20 μg for those above 10 years old and 10 μg for those below 10 years old) on d 0, 30and 60. One hundred and sixty-six subjects were enrolled(87 males and 76 females aged 5-35 years). The main outcome measure was assessment of immunogenicity and safety.RESULTS: A 100% seroconversion response was observed on the 30th d after the 1st injection in both the experimental groups. The sero-protection data reported a 41.2-65.6% response on the 30th d after the 1st injection and reached 100% on the 60th d. Descriptive statical analysis showed a geometric mean titer value of 13.77 mIU/mL in the test (BEVAC) group and 10.95 mIU/mL in the commercial control (ENGERIX-B) group on the 30th d after the 1st injection. The response on the 60th d showed a geometric mean titre value (GMT) of 519.84 mIU/mL in the BEVAC group and 475.46 mIU/mL in the ENGERIX-B group. On the 90th d, the antibody titer response was observed to be 2627.58 mIU/mL in the BEVAC group and 2272.72 mIU/mL in the ENGERIX-B group. Two subjects in each group experienced pains at injection site after the first vaccination. A total of six subjects in both groups experienced a solicited adverse reaction, which included pains, swelling and redness at the injection site, three subjects in the group-B had a pain at the injection site after the third dose. No other serious adverse events occurred and no dose-related local or general symptoms were observed during the study.CONCLUSION: The vaccine is safe, efficacious and immunogenic in comparison with the well documented ENGERIX-B. | A Chowdhury A Santra CM Habibullah AA Khan J Karunakaramaiah TSA Kishore AVR Raju S Lahiri | 2005 | World Journal of Gastroenterology2005，11，7： | 12 |
| 2 | Advanced trauma life support,8th editon,the evidence for change显示文摘 | Kortbeek JB Al TSA Ali J | 2008 | J Trauma2008，64，6： | 1 |
| 3 | Effect of TiO2 nanoparticles on the electropolymerization of polypyrrole显示文摘 | Liu Y C Huang J M Tsa C E | 2004 | Chem Phys Lett2004，387，： | 1 |
| 4 | Fatigue and fracture properties of yttria partially stabilized zirconia crown systems 显示文摘 | Tsa|ouchou E Cattell M J Knowles JC et a| | 2008 | Dent Mater2008，24，3： | 1 |
| 5 | Variations in the NRAMP1 gene and susceptibility of tuberculosis in Taiwanese显示文摘 | LIAW Y S TSA I WU J J | 2002 | Int J Tuberc Lung Dis2002，6，5： | 1 |
| 6 | Post-Cu CMP cleaning for colloidal silica abrasive removal 显示文摘 | CHEN P L CHEN J H TSA! M S | 2004 | Microelectronic Engineering2004，75，4： | 1 |
| 7 | A quantum search algorithm for future spacecraft attitude determina- tion显示文摘 | Tsa J Hsiao F Y Li Y J | 2011 | Acta Astronautica2011，68，： | 1 |
| 8 | Multi-cluster,mobile,multi-media radio network 显示文摘 | GERLA M TSA I J | 1995 | W ireless Networks1995，1，25： | 1 |
| 9 | A context-aware ubiquitous learning environment for conducting complex science experiments 显示文摘 | Hwang G J YANG T C Tsa C C | 2009 | Computers and Education2009，53，2： | 1 |
| 10 | Skeletonization ofThree-dimensional Object Using Generalized Poten-tial Field显示文摘 | Chuang J Tsa I C Ko M C | 2000 | IEEE Transactions on Pattern Analy-sis and Machine Intelligence2000，22，11： | 1 |
| 11 | Effects of ring characteristics on the compressive strength and dynamic modulus of elasticity of seven softwood species 显示文摘 | LIN C J TSA M J | 2007 | Holzforschung2007，61，4： | 1 |
| 12 | A Pilot Study for Determin- ing the Optimal Operation Condition for Simultaneously Con- trolling the Emissions of PCDD/Fs and PAHs From the Iron Ore Sintering Process显示文摘 | Chen Y C Tsa i P J Mou J L | 2012 | Chemosphere2012，88，11： | 1 |
| 13 | Multicluster, mobile, multi-media radio network显示文摘 | Gerla M Tsa I J | 1995 | Wireless Networks1995，1，3： | 1 |
| 14 | A boundary method for outli- er detection based on support vector domain description 显示文摘 | Guo S M Chen L C Tsa I J S H | 2009 | Pattern Recognition2009，42，1： | 1 |
| 15 | Influence of an Asian dust storm and Southeast Asian biomass burning on the characteristics of seashore atmospheric aerosols in Southern Talwan 显示文摘 | TSA J H HUANG K L LIN N H | 2012 | Aerosol and Air Quality Research2012，12，6： | 1 |
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