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| 1 | Post-translational regulation of inflammasomes显示文摘在对微生物引起的感染的有免疫力的保护的 Inflammasomes 戏必需品角色。然而,过多的发炎在各种各样的人的疾病被含有,包括 autoinflammatory 症候群,糖尿病,多重硬化,心血管的混乱和 neurodegenerative 疾病。因此,当限制并行的织物损坏时, inflammasome 活动的精确规定为足够的有免疫力的保护是批评的。在这评论,我们集中于调整 NLRP3, NLRP1, NLRC4, AIM2 和 IFI16 inflammasomes 的激活的 translational 以后修正(PTM ) 的新兴的角色。我们预计 PTM 的这些类型将在另外的类型和更少的描绘得好的 inflammasomes 被识别。因为这些高度多样、万用的 PTM 响应感染和织物损坏塑造不同煽动性的回答,指向酶在这些包含了 PTM 将无疑在各种各样的 pathophysiological 条件下面为 inflammasome 活动的精确调整提供机会。 | Jie Yang Zhonghua Liu Tsan Sam Xiao | 2017 | Cellular & Molecular Immunology2017，14，1： | 15 |
| 2 | Effect of oral epidermal growth factor on mucosal healing in rats with duodenal ulcer显示文摘AIM: To investigate the effect of epidermal growth factor (EGF) on mucosal healing in rats with duodenal ulcer.METHODS: Male Sprague-Dawley rats were randomly divided into sham operation without EGF, sham operation with EGF, duodenal ulcer without EGF, or duodenal ulcer with EGF groups. Additionally, normal rats without operation served as the control group. Duodenal ulcer was induced in rats by 300 mL/L acetic acid. Rats with EGF were orally administered at a dose of 60 μg/kg/day in drinking water on the next day of operation (day 1). Healing of duodenal ulcer was detected by haematoxylin and eosin staining. Cell growth of damaged mucosa was determined by the contents of nucleic acids and proteins. The level of EGF in duodenal mucosa was measured by ELISA.RESULTS: The pathological results showed that duodenal ulcer rats with EGF improved mucosal healing compared with those without EGF after day 5. Duodenal ulcer rats with EGF significantly increased duodenal DNA content compared with those without EGF on day 15 (6.44±0.54mg/g VS 1.45±0.52 mg/g mucosa, P<0.05). Duodenal RNA and protein contents did not differ between duodenal ulcer rats with and without EGF during the experimental period.Sham operation and duodenal ulcer rats with EGF significantly increased duodenal mucosal EGF content compared with those without EGF on day 5 (76.0±13.7 ng/g VS 35.7±12.9ng/g mucosa in sham operation rats, and 68.3±10.9 ng/gVS 28.3±9.2 ng/g mucosa in duodenal ulcer rats, P<0.05).CONCLUSION: Oral EGF can promote mucosal healing of the rats with duodenal ulcer by stimulating mucosal proliferation accompanied by an increase in mucosal EGF content. | Jane CJ Chao Kuo-Yu Liu Sheng-Hsuan Chen Chia-Lang Fang Chih-Wei Tsan | 2003 | World Journal of Gastroenterology2003，9，10： | 9 |
| 3 | 基层医疗国际分类对城市全科医疗门诊老年患者就诊原因及服务需求的评价显示文摘目的 了解北京和天津城市全科医疗诊所中老年患者的患病情况和就诊原因 ;探索以基层医疗国际分类 (ICPC)方法客观评价居民医疗服务需求的状况。方法 采用典型抽样的方法 ,选取在 1999年 11月~ 2 0 0 0年 2月间、每个月前 2周中因不同原因到上述全科医疗门诊就诊的≥ 6 5岁的老人作为研究对象 ,共获得样本量为 2 85 9人次 ;由全科医生对其就诊情况进行记录 ,并使用基层医疗国际分类 (ICPC - 2 )对所记录的就诊原因和健康问题进行分类和编码。进而将分析结果与香港的研究结果进行比较。结果 老年人的首位就诊原因是头晕 ;就诊原因中的 4 1 6 %和健康问题 (诊断 )中的 6 0 3%属于心血管系统 ;2 4 6 %的患者患有高血压和相关疾病 ;研究地区与香港地区老年人的健康问题有所不同。结论 ICPC是研究居民就诊原因和医疗服务需求的有效而实用的工具。研究地区中老年人的主要健康问题是慢性疾患 ,特别是心血管疾病 ,此提示慢性病是目前及今后全科医疗服务的主要内容 ,而全科医生的继续教育亦应顺应患者的需求。 | 路孝琴 贾庆春 梁万年 Wun Yuke Tsan 瓮学清 | 2004 | 中国全科医学2004，7，12： | 7 |
| 4 | 城市社区卫生服务站老年患者就诊原因及患病状况研究显示文摘 | 路孝琴 贾庆春 梁万年 Wun Yuke Tsan 彭晓霞 | 2004 | 中华全科医师杂志2004，3，5： | 5 |
| 5 | Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study显示文摘 | Tsan Yang Chi-Hong Chu Chyi-Huey Bai San-Lin You Yu-Ching Chou Wan-Yun Chou Kuo-Liong Chien Lee-Ching Hwang Ta-Chen Su Chin-Hsiao Tseng Chien-An Sun | 2011 | Atherosclerosis2011，，2： | 2 |
| 6 | Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis显示文摘 | Huay‐Min WANG Gin‐Ho LO Wen‐Chi CHEN Ping‐I HSU Hsien‐Chung YU Chiun‐Ku LIN Hoi‐Hung CHAN Wei‐Lun TSAI Feng‐Woei TSAY Tsan‐Ping LIU E‐Ming WANG Kwok‐Hung LAI | 2012 | Journal of Digestive Diseases2012，，8： | 2 |
| 7 | Antralization at the edge of proximal gastric ulcers:Does Helicobacter pylori infection play a role?显示文摘AIM: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect ofH. pylori eradication on the mucosal appearances.
METHODS: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type.H. pylori positive patients receivedeither triple therapy, or omeprazole.
RESULTS: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge inH. pylori-positive patients thanH.pylori-negative patients (93% vs 60%, OR=8.95,95%CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61%, P=0.004) at the ulcer edge in patients with H. pyloribeing eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection.
CONCLUSION: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection. | Harry Hua-Xinag Xia Shiu Kum Lam Wai Man Wong Wayne Hsing Cheng Hu Kam Chuen Lai Sau Hing Wong Suet Yi Leung Siu Tsan Yuen Nicholas A.Wright Benjamin Chun-Yu Wong | 2003 | World Journal of Gastroenterology2003，9，6： | 2 |
| 8 | Comparative analyses of current three-dimensional numerical solar wind models显示文摘We present a comparative study of the most advanced three-dimensional time-dependent numerical simulation models of solar wind. These models can be classified into two categories:(I) theoretical, empirical and numerically based models and(II) self-consistent multi-dimensional numerical magnetohydrodynamic(MHD) models. The models of Category I are used to separately describe the solar wind solution in two plasma flows regions: transonic/trans-Alfvénic and supersonic/super-Alfvénic, respectively. Models of Category II construct a complete, single, numerical solar wind solution through subsonic/sub-Alfvénic region into supersonic/super-Alfvénic region. The Wang-Sheeley-Arge(WSA)/ENLIL in CISM is the most successful space weather model that belongs to Category I, and the Block-Adaptive-Tree-Solarwind-Roe-Upwind-Scheme(BATS-R-US) code in SWMF(Space Weather Modeling Framework) and the solar-interplanetary conservative element solution element MHD(SIP-CESE MHD) model in SWIM(Space Weather Integrated Model) are the most commonly-used models that belong to Category II. We review the structures of their frameworks, the main results for solar wind background studies that are essential for solar transient event studies, and discuss the common features and differences between these two categories of solar wind models. Finally, we conclude that the transition of these two categories of models to operational use depends on the availability of computational resources at reasonable cost and point out that the models' prediction capabilities may be improved by employing finer computational grids, incorporating more observational data and by adding more physical constraints to the models. | Shi Tsan WU Murray DRYER | 2015 | Science China Earth Sciences2015，58，6： | 2 |
| 9 | Statin use and the risk of cirrhosis development in patients with hepatitis C virus infection显示文摘 | Yao-Hsu Yang Wen-Cheng Chen Yu-Tse Tsan Mei-Jyh Chen Wei-Tai Shih Ying-Huang Tsai Pau-Chung Chen | 2015 | Journal of Hepatology2015，，5： | 2 |
| 10 | Changes in uhrastructure and abscisic acid level and response to applied gibberellins in Taxus rnalrei seeds treated with warm and cold stratification显示文摘 | CHING T C LING L H TSAN P L | 1998 | Annals of Botany1998，81，： | 1 |
| 11 | The relationship between sleep apnea syndrome and hypothyroidism 显示文摘 | Lin CC Tsan KW Chen PJ | 1992 | Chest1992，102，6： | 1 |
| 12 | The assessment of bfliary CA125,CA19-9 and CEA in diagnosing cholangiocarcinoma the influence of sampling time and hepatofitlliasis显示文摘 | Chen CY Shiosh SC Tsan HC | 2012 | Hepatogastroenterology2012，49，45： | 1 |
| 13 | Mechanism of gallium - 67 accumulation in inflammatory le- sions显示文摘 | Tsan MF | 1985 | JNuclMed1985，26，： | 1 |
| 14 | Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors显示文摘 | Tsan MF Baochong G | 2007 | J Endotoxin Res2007，13，10： | 1 |
| 15 | Analysis of some difference approximations for a singular perturbation problem without turning points显示文摘 | KELLOGG R B TSAN A | 1978 | Math of Comp1978，144，32： | 1 |
| 16 | Assessing site selection criteria for Taiwan Lantern Festival by analytic hierarchy process 显示文摘 | Tsai H Tsan Ho P | 2009 | Event Management2009，12，34： | 1 |
| 17 | Use of thiazolidined iones and the risk of colorectal cancer in patients with diabetes: A nationwide, population- based, case-control study显示文摘 | Chen SW Tsan YT Chen JD | 2013 | Diabetes care2013，36，2： | 1 |
| 18 | The relationship between sleep apnea syndrome and hypothyroidism 显示文摘 | Lin CC Tsan KW Chen PJ | 1992 | Chest1992，102，6： | 1 |
| 19 | Endogenous ligands of Toll-like receptors显示文摘 | Tsan MF Gao B | 2004 | J Leukoc Biol2004，76，： | 1 |
| 20 | Optimization of Dry Machining Parameters for High-purity Graphite in End Milling Process via Design of Experiments Methods显示文摘 | Yung Kuang Yang Ming Tsan Chuang Show Shyan Lin | 2009 | Journal of Materials Processing Technology2009，209，9： | 1 |
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