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| 1 | βⅢ-Tubulin过表达与ERG融合、PTEN缺失密切相关,是预测前列腺癌进展的独立因素显示文摘前列腺癌是西方国家男性最常见的恶性肿瘤之一。目前确立的预后指标包括Gleason分级、肿瘤范围、术前PSA水平以及临床分期等,但这些参数都不足以使个体化治疗决策达到最优化,为此,作者拟寻找更合适的生物学标记来全面了解前列腺癌的生物学行为。 | Tsourlakis M C Weig P Grupp K 陈佳菁 林慧 余英豪 | 2014 | 临床与实验病理学杂志2014，30，6： | 6 |
| 2 | Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus显示文摘 | Reichelt U Duesedau P Tsourlakis MCH | 2007 | Mod Pathol2007，20，10： | 1 |
| 3 | Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus显示文摘 | Reichelt U Duesedau P Tsourlakis MCh | | 0，，01： | 1 |
| 4 | Frequent homogeneous HER-2 amplification in primary and metastatic adenocarciuoma of the esophagus 显示文摘 | Reicheh U Duesedau P Tsourlakis MCh | 2007 | Mod Pathol2007，20，1： | 1 |
| 5 | Frequenthomogeneous HER-2 amplification in primary and metastaticadenocarcinoma of the esophagus 显示文摘 | Reichelt U? Duesedau P Tsourlakis MCh | 2007 | Mod Pathol2007，20，1： | 1 |
| 6 | Overexpression of the chromatin remodeler death-domain-associated protein in prostate cancer is an independent predictor of early prostate-specific antigen recurrence 显示文摘 | Tsourlakis MC Schoop M Plass C | 2013 | Hum Pathol2013，44，9： | 1 |
| 7 | Heterogeneity of ERBB2 amplification in ad , squamous cell carcinoma and large cell undifferentiated carcinoma of the lung 显示文摘 | Grob TJ Kannengiesser I Tsourlakis MC | 2012 | Mod Path&2012，25，12： | 1 |
| 8 | Heterogeneity of ERBB2 amplification in adenocarcinoma, squamous cell carcinoma and large cell undifferentiated carcinoma of the lung 显示文摘 | Grob TJ Kannengiesser I Tsourlakis MC | 2012 | Mod Patho12012，25，12： | 1 |
| 9 | Frequent homogeneous HER-2amplification in primary and metastatic adenocarcinoma of the esophagus显示文摘 | Reichelt U Duesedau P Tsourlakis MC | 2007 | J Mod Pathol2007，20，1： | 1 |
| 10 | Frequent homo-geneous HER-2 amplification in primary and metastatic adenocarci-noma of theesophagus显示文摘 | Reichelt U Duesedau P Tsourlakis MCh | 2007 | Mod Pathol2007，20，1： | 1 |
| 11 | Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus显示文摘 | Reichelt U Duesedau P Tsourlakis MCh | 2007 | Mod Pathol2007，20，1： | 1 |
| 12 | Loss of PSP94 expression is associated with early PSA recurrence and deteriorates outcome of PTEN deleted prostate cancers显示文摘Objective: Prostate secretory protein of 94 amino acids(PSP94) is a target gene of the EZH2 transcriptional repressor and is often downregulated in prostate cancer;however, its prognostic value is disputed.Methods: Immunohistochemical analysis of a tissue microarray of 12, 432 prostate cancer specimens was performed to evaluate PSP94 expression. Correlation of PSP94 expression with tumor phenotype, patient prognosis, TMPRSS2:ERG fusion status, EZH2 expression and PTEN deletion was studied.Results: PSP94 expression was increased in benign prostatic hyperplasia;however, it was downregulated in 48% and negative in42% of the 9, 881 interpretable prostate cancer specimens. The loss of PSP94 expression was inversely correlated to EZH2 expression(P < 0.0001) and largely unrelated to the ERG status, but strongly correlated with high Gleason grade, advanced tumor stage, and nodal metastasis(P <0.0001 each). The fraction of PSP94-negative cancer specimens increased from 40% in pT2 to 52%in pT3 b-pT4(P < 0.0001) and from 40% in Gleason 3+3 = 6 to 46% in Gleason 4+3 = 7 and 60% in Gleason ≥4+4 = 8(P <0.0001). Loss of PSP94 was linked to early prostate-specific antigen recurrence, but with little absolute effect(P < 0.0001).However, it provided additional prognostic impact in cancer specimens with PTEN deletion. Loss of PSP94 deteriorated prognosis of cancer patients with PTEN deletion by more than 10%(P < 0.0001). The combination of PTEN deletion and PSP94 loss provided independent prognostic information that was observed in several subgroups defined by classical and quantitative Gleason grade.Conclusions: The results of our study suggest that combined PSP94/PTEN analysis can be potentially used in the clinical prognosis of prostate cancer. | Andreas M. Luebke Ali Attarchi-Tehrani Jan Meiners Claudia Hube-Magg Dagmar S. Lang Martina Kluth Maria Christina Tsourlakis Sarah Minner Ronald Simon Guido Sauter Franziska Buscheck Frank Jacobsen Andrea Hinsch Stefan Steurer Thorsten Schlomm Hartwig Huland Markus Graefen Alexander Haese Hans Heinzer Till S. Clauditz Eike Burandt Waldemar Wilczak Doris Hoflmayer | 2019 | Cancer Biology & Medicine2019，16，2： | 1 |
| 13 | Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus 显示文摘 | Reichelt U Duesedau P Tsourlakis MC | 2007 | Mod Pathol2007，20，1： | 1 |
| 14 | Frequent homoge- neous HER-2 amplification in primary and metastatic adenocarcino- ma of the esophagus 显示文摘 | Reichelt U Duesedau P Tsourlakis MC | 2007 | Mod Pathol2007，20，1： | 1 |
| 15 | The prognostic value of SUMO1/Sentrin specific peptidase 1(SENP1)in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion显示文摘 | Burdelski C Menan D Tsourlakis MC | 2015 | BMC Cancer2015，，15： | 1 |
| 16 | Epidermal growth factor receptor (EGFR) in salivary gland carcinomas: Potentials as therapeutic target显示文摘 | Till Sebastian Clauditz Artur Gontarewicz Patrick Lebok Maria-Christina Tsourlakis Tobias J. Grob Adrian Münscher Guido Sauter Carsten Bokemeyer Rainald Knecht Waldemar Wilczak | 2012 | Oral Oncology2012，，10： | 1 |
| 17 | Frequent Homoge- nous HER2 Amplication in Primary and Metastatic Adenocarcinomas of Theesophagus显示文摘 | Reicheh U Duesedau P Tsourlakis MCh | 2007 | Mod Path2007，20，1： | 1 |
| 18 | Heterogeneity of ERBB2 amplification in adenocarcinoma,squamous cell carcinoma and large cell undifferentiated carcinoma of the lung 显示文摘 | Grob TJ Kannengiesser I Tsourlakis MC | 2012 | Mod Pathol2012，25，12： | 1 |
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