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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 3 | Microstructure,chemical and tribological investigations of MoxW1-xSy co-sputtered composite films显示文摘 | YIN G L HUANG P H YU Z HE D N TU J P | 2006 | Tribology Letters2006，22，1： | 1 |
| 4 | 显示文摘 | Sze Tu L Dehghani F Foster N R | 2002 | Powder Technology2002，126，： | 1 |
| 5 | A novel methodology for computer-aided process planning 显示文摘 | Chu X N Tso S K Tu Y L | 2000 | The International Journal of Advanced Manufacturing Technology2000，，16： | 1 |
| 6 | Effects of elevated CO2 levels on root morphological traits and Cd uptakes of two Lolium species under Cd stress显示文摘 | Jia Y Tang S R Ju X H Shu L N Tu S X Feng R W Giusti L | 2011 | Journal of Zhejiang University of Science2011，12，4： | 1 |
| 7 | Leptin and regula- tory T lymphocytes in idiopathic pulmonary arterial hy- pertension显示文摘 | Huertas A Tu L Gambaryan N | 2012 | Eur Respir J2012，40，4： | 1 |
| 8 | Correlations betweenblood and tissue omega-3 LCPUFA status following dietary ALA in-tervention in rats显示文摘 | Tu W C Mti hlh usler B S Yelland L N | 2013 | Prostaglandins Leukotrienes and Essential FattyAcids2013，88，1： | 1 |
| 9 | A novel methodology for compurer aided process planning显示文摘 | CHU X N TSO S K TU Y L | 2000 | Advanced Manufacturing Technology2000，16，10： | 1 |
| 10 | Structure and properties of lead-free solders bearing micro and nanoparticles 显示文摘 | Zhang L Tu K N | 2014 | Materials Science and Engineering Reports2014，82，： | 1 |
| 11 | Cationic long-chain hyperbranched poly(ethylene glycol)s with low charge density for gene delivery显示文摘 | Tu C Li N Zhu L | 2013 | Polymer Chemistry2013，4，2： | 1 |
| 12 | Changes in catechins during the fermentation of green tea 显示文摘 | Tu Y Y Xia H L Watanabe N | 2005 | Applied Biochemistry and Microbiology2005，41，6： | 1 |
| 13 | Indices of novelty for emerging topic detection 显示文摘 | Tu Y N Seng J L | 2012 | Information Processing & Management2012，48，2： | 1 |
| 14 | Constitutive and tissue-specific differential expression of the cryIA(b)gene in transgenic rice plants conferring resistance to rice insect pest显示文摘 | Datta K Vasquez A Tu J M Tonizo L Alam M F Oliva N Abrigo E Cohen M Khush G S and Datta SK | | 0，，： | 1 |
| 15 | Effect of display technology on the crosstalk perception in stereoscopic video content显示文摘 | WANGL TU Y A N CHEN L I etal | 2012 | IEEE Transactions on Circuits and Systems for Video Technology2012，22，9： | 1 |
| 16 | A novel methodology for computer aided process planning显示文摘 | CHU X N TSO S K TU Y L | 2000 | International Journal of Advanced Manufacturing Technology2000，16，10： | 1 |
| 17 | BAX activation is initiated at a novel interaction site显示文摘 | Gavathiotis E Suzuki M Davis M L Pitter K Bird G H Katz S G Tu H C Kim H Cheng E H Tjandra N Walensky L D | 2008 | Nature2008，455，7216： | 1 |
| 18 | Volatile constit- uents of Vietnamese purnrnelo, orange, tangerine and lime peel oils 显示文摘 | Minh Tu N T Thanh L X Une A | 2002 | Flavour and Fragrance Journal2002，17，3： | 1 |
| 19 | In-situ scanning electron-microscopecomparison studies on electromigration of Cu and Cu (Sn) alloys foradvanced chip interconnects显示文摘 | Lee K L Hu C K Tu K N | 1995 | Journal of Applied Physics1995，78，7： | 1 |
| 20 | Implications of Mercury Speciation in Thiosulfate Treated Plants显示文摘 | Wang J Feng X Anderson C W N Wang H Zheng L Tu T | 2012 | Environ Sci Technol2012，46，10： | 1 |
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