| 1 | Vegetation and Soil Characteristics of Different Desertification Grasslands in Northwest Sichuan显示文摘[Objective]The paper was to study vegetation and soil characteristics of different desertification grasslands in northwest Sichuan. [Method]By taking different desertification grasslands as the research object,the characteristic factors of vegetation community,biomass,soil moisture content,volume weight and porosity were analyzed through scientific investigation,sampling and formula calculation to reveal the changes in vegetation and soil characteristics of different desertification grasslands in Northwest Sichuan. [Result]Community succession presented the pattern of ' hygrophyte-mesophyte-xerophyte' with the aggravation of grassland desertification. The height and coverage of community decreased,species richness was declined by 88%,and composition of dominant species also changed greatly. The diversity index of light-desertification grassland was the highest among tested grasslands. Total biomass was decreased by 90. 4%,and the underground biomass decreased far more than aboveground biomass. In desertification progress,both soil moisture content and water holding capacity decreased,while volume weight showed upward trend and porosity showed downward trend; soil characteristics had large variation in early stage of desertification,so restoration treatment of desertification grassland should be carried out in the early stage of desertification. [Conclusion]The study provided a theoretical basis for researches on causes and management programs of desertification grassland,having an important meaning for ecological restoration of regional grassland and maintenance of ecological security. | Wan Ting Tu Weiguo Xi Huan Li Yudong Tang Xuefang Yang Yichuan | 2014 | Animal Husbandry and Feed Science2014，6，2： | 1 |
| 2 | Nanoengineered Gallium Ion Incorporated Formulation for Safe and Efficient Reversal of PARP Inhibition and Platinum Resistance in Ovarian Cancer显示文摘Platinum-based chemotherapy remains the main systemic treatment of ovarian cancer(OC).However,the inevitable development of platinum and poly(adenosine diphosphate-ribose)polymerase inhibitor(PARPi)resistance is associated with poor outcomes,which becomes a major obstacle in the management of this disease.The present study developed“all-in-one”nanoparticles that contained the PARPi olaparib and gallium(Ga)(III)(olaparib-Ga)to effectively reverse PARPi resistance in platinum-resistant A2780-cis and SKOV3-cis OC cells and in SKOV3-cis tumor models.Notably,the olaparib-Ga suppressed SKOV3-cis tumor growth with negligible toxicity.Moreover,the suppression effect was more evident when combining olaparib-Ga with cisplatin or carboplatin,as evaluated in A2780-cis and SKOV3-cis cells.Mechanistically,the combined treatment induced DNA damage,which elicited the activation of ataxia telangiectasia mutated(ATM)/AMT-and Rad3-related(ATR)checkpoint kinase 1(Chk1)/Chk2 signal transduction pathways.This led to the arrest of cell cycle progression at S and G2/M phases,which eventually resulted in apoptosis and cell death due to unrepairable DNA damage.In addition,effective therapeutic responses to olaparib-Ga and cisplatin combination or olaparib-Ga and carboplatin combination were observed in SKOV3-cis tumor-bearing animal models.Altogether,the present findings demonstrate that olaparib-Ga has therapeutic implications in platinum-resistant OC cells,and the combination of olaparib-Ga with cisplatin or carboplatin may be promising for treating patients with OC who exhibit resistance to both PARPi and platinum. | Yangyang Li Yixuan Cen Mengyan Tu Zhenzhen Xiang Sangsang Tang Weiguo Lu Hongbo Zhang Junfen Xu | 2023 | Research2023，，3： | 0 |
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