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| 1 | Prognostic value of interim ^(18)F-FDG PET/CT in diffuse large B-cell lymphoma显示文摘Objective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim 18F-FDG PET/CT after first-line treatment in patients with DLBCL. Methods: Thirty-two patients with DLBCL underwent baseline, interim and post-treatment 18F-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively. Results: Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim 18F-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival (PFS) rates were significantly different between the groups above and below SUV max cut-off value of 2.5 (P=0.039). No significant differences were found in the 2-year PFS rates if SUV max cut-off values were set as 2.0 and 3.0, respectively (P=0.360; P=0.113). Conclusions: Interim PET/CT could predict the prognosis of DLBCL patients with the SUV max cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion. | Zhitao Ying Xuejuan Wang Yuqin Song Wen Zheng Xiaopei Wang Yan Xie Ningjing Lin Meifeng Tu Lingyan Ping Weiping Liu Lijuan Deng Chen Zhang Zhi Yang Jun Zhu | 2013 | Chinese Journal of Cancer Research2013，25，1： | 4 |
| 2 | Prognostic value of pre-and post-transplantation 18F-fluorodeoxyglucose positron emission tomography results in non-Hodgkin lymphoma patients receiving autologous stem cell transplantation显示文摘Objective: High-dose chemotherapy(HDC) followed by autologous stem cell transplantation(ASCT) is the standard of care in the upfront or relapsed/refractory setting in some patients with non-Hodgkin lymphoma(NHL).However,a proportion of patients do not respond to ASCT.^(18)F-fluorodeoxyglucose(FDG) positron emission tomography(PET)/computed tomography(CT) has been widely used for staging,response evaluation,and prognosis prediction.Here,we investigated the prognostic role of PET/CT in NHL patients before and after ASCT.Methods: A retrospective study was conducted at Peking University Cancer Hospital.All NHL patients who underwent ASCT between March 2010 and July 2016 were identified.Patients who had PET/CT scan before and after ASCT were included.Deauville criteria(5-point scale) were used to interpret PET scans.Univariate and multivariate survival analyses were performed using Cox regression.The predictive value of PET scanning was estimated by comparing the area under the receiver operating characteristic(ROC) curve.Results: In total,79 patients were enrolled in this study.In univariate analysis,pre-and post-ASCT PET result was identified as prognostic factors for 3-year progression-free survival(PFS) and overall survival(OS).Patients with negative pre-ASCT PET result demonstrated significantly better PFS(84.2% vs.54.2%) and OS(89.2% vs.63.6%) than patients with positive pre-ASCT PET result.PFS(91.6% vs.25.3%) and OS(96.5% vs.36.8%) were also significantly different between patients with negative and positive post-ASCT PET result.Multivariate analysis also showed a significant association between survival and post-ASCT PET result.ROC analysis revealed that the predictive value of post-ASCT PET result was superior to that of pre-ASCT PET result alone.Combined pre-and post-ASCT PET result is better for predicting outcomes in patients with NHL receiving transplantation.Deauville criteria score >3 was identified as the best cutoff value for post-ASCT PET.Conclusions: Post-ASCT PET result was more important than pre-ASCT PET result in predicting outcomes for NHL patients who underwent ASCT.The prognostic significance can be improved when combining preASCT PET result with post-ASCT PET result.Deauville criteria can be used for interpreting PET scans in this scenario. | Zhitao Ying Lan Mi Xuejuan Wang Yuewei Zhang Zhi Yang Yuqin Song Xiaopei Wang WenZheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu LijuanDeng Jun Zhu | 2017 | Chinese Journal of Cancer Research2017，29，6： | 3 |
| 3 | Shallow Convolutional Neural Networks for Acoustic Scene Classification显示文摘最近,深神经的网络,它包括 convolutional 神经网络(CNN ) ,广泛地被用于声学的景色分类(ASC ) 。由一些简化 CNN 在深 CNN 上看了改进的事实激发了,例如视觉几何学组网(VGG 网) ,我们弄明白怎么与改进性能简化 VGG 网风格体系结构到浅 CNN。分享的马克斯和正规化也是的批申请了更好的精确性。与声学的场面和事件(DCASE ) 的察觉和分类上的一系列控制测试, 2016 数据设定,我们的浅 CNN 完成 6.7% 改进,并且把时间复杂性归结为 5% ,与 VGG 网风格 CNN 相比。 | LU Lu YANG Yuhong JIANG Yuzhi AI Haojun TU Weiping | 2018 | Wuhan University Journal of Natural Sciences2018，23，2： | 3 |
| 4 | The protective role of hydrogen-rich saline in experimental liver injury in mice显示文摘 | HanYong Sun Lei Chen WeiPing Zhou Liang Hu Liang Li QianQian Tu YanXin Chang Qu Liu XueJun Sun MengChao Wu HongYang Wang | 2010 | Journal of Hepatology2010，，3： | 2 |
| 5 | PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma显示文摘Objective: Although L-asparaginase(L-ASP) is a standard treatment for lymphoblastic lymphoma(LBL),hypersensitivity reactions by some patients limit its application. Polyethylene glycol-conjugated asparaginase(PEGASP) has a lower immunogenicity and is a standard treatment in all pediatric acute lymphoblastic leukemia(ALL).In this study, we investigated the efficacy and toxicity of PEG-ASP instead of L-ASP as used in the BFM-90regimen(PEG-ASP-BFM-90) for adult LBL.Methods: Between June 2012 and July 2015, we treated 30 adult patients with newly diagnosed LBL, using PEGASP-BFM-90 in a prospective, multicenter and single-arm clinical study at 5 participating institutions in China.Results: All the 30 patients, including 19 males and 11 females with a median age of 30(range: 18–62) years,completed 128 times of the PEG-ASP, with the median of 4(range: 2–6) times. Patients did not receive radiotherapy at this time. The overall response rate was 86.7%(26/30), with 50.0%(15/30) complete response and36.7%(11/30) partial response. The 3-year overall survival was 46.0% [95% confidence interval(95% CI),28.2%–64.8%], and the 3-year progression-free survival was 43.0%(95% CI, 25.7%–62.0%). Major adverse events were myelosuppression, reduced fibrinogen, liver dysfunction and digestive tract toxicities. No allergic reaction and no treatment-related mortality or severe complications were recorded.Conclusions: Our clinical data and observed outcomes indicate that 1 dose of PEG-ASP can replace multiple doses of native L-ASP in BFM-90, with predominantly grade 3–4 neutropenia for adult LBL, and no therapyrelated deaths. The effect is similar to previous reports of PEG-ASP-containing regimens for adult ALL. Major advantages include less serious allergic reactions, 2–3 weeks of action duration, and convenience for patients and physicians. | Wen Zheng Hanyun Ren Xiaoyan Ke Mei Xue Yongqing Zhang Yan Xie Ningjing Lin Meifeng Tu Weiping Liu Lingyan Ping Zhitao Ying Chen Zhang Lijuan Deng Xiaopei Wang Yuqin Song Jun Zhu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 2 |
| 6 | Nonlinear Prediction with Deep Recurrent Neural Networks for Non-Blind Audio Bandwidth Extension显示文摘Non-blind audio bandwidth extension is a standard technique within contemporary audio codecs to efficiently code audio signals at low bitrates. In existing methods, in most cases high frequencies signal is usually generated by a duplication of the corresponding low frequencies and some parameters of high frequencies. However, the perception quality of coding will significantly degrade if the correlation between high frequencies and low frequencies becomes weak. In this paper, we quantitatively analyse the correlation via computing mutual information value. The analysis results show the correlation also exists in low frequency signal of the context dependent frames besides the current frame. In order to improve the perception quality of coding, we propose a novel method of high frequency coarse spectrum generation to improve the conventional replication method. In the proposed method, the coarse high frequency spectrums are generated by a nonlinear mapping model using deep recurrent neural network. The experiments confirm that the proposed method shows better performance than the reference methods. | Lin Jiang Ruimin Hu Xiaochen Wang Weiping Tu Maosheng Zhang | 2018 | China Communications2018，15，1： | 2 |
| 7 | A durable 4-1BB-based CD19 CAR-T cell for treatment of relapsed or refractory non-Hodgkin lymphoma显示文摘Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However,the median progression-free survival(mPFS)of 4-1BB-based product Kymriah was shorter than that of CD28-based Yescarta(2.9 months vs.5.9 months),suggesting that Kymriah was limited in the long-term efficacy.Thus,a safe and durable 4-1BB-based CD19 CAR-T needs to be developed.Methods:We designed a CD19-targeted CAR-T(named as IM19)which consisted of an FMC63 scFv,4-1BB and CD3ζintracellular domain and was manufactured into a memory T-enriched formulation.A phase I/II clinical trial was launched to evaluate the clinical outcomes of IM19 in relapsed or refractory(r/r)B cell non-Hodgkin lymphoma(B-NHL).Dose-escalation investigation(at a dose of 5×10^(5)/kg,1×10^(6)/kg and 3×106/kg)was performed in 22 r/r B-NHL patients.All patients received a single infusion of IM19 after 3-day conditional regimen.Results:At month 3,the overall response rate(ORR)was 59.1%,the complete response rate(CRR)was 50.0%.The mPFS was 6 months and the 1-year overall survival rate was 77.8%.Cytokine release syndrome(CRS)occurred in 13 patients(59.1%),with 54.5%of grade 1−2 CRS.Only one patient(4.5%)experienced grade 3 CRS and grade 3 neurotoxicity.Conclusions:These results demonstrated the safety and durable efficacy of a 4-1BB-based CD19 CAR-T,IM19,which is promising for further development and clinical investigation. | Zhitao Ying Ting He Shanzhao Jin Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Weiping Liu Lijuan Deng Yanping Ding Xuelian Hu Bing Bu Xin’an Lu Yuqin Song Jun Zhu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 8 | Prognostic value of ^(18)F-fluorodeoxyglucose positron emission tomography using Deauville criteria in diffuse large B cell lymphoma treated with autologous hematopoietic stem cell transplantation显示文摘Objective: High-dose chemotherapy(HDC) followed by autologous hematopoietic stem cell transplantation(auto-HSCT) plays an important role in improving outcomes of diffuse large B cell lymphoma(DLBCL) patients.18 F-fluorodeoxyglucose(18 F-FDG) positron emission tomography(PET)/computed tomography(CT) has been widely accepted in response assessment and prediction of prognosis in DLBCL. Here, we report the value of 18 FFDG PET/CT pre-and post-HSCT in predicting outcomes of patients with DLBCL.Methods: DLBCL patients who had PET/CT scan before and after HSCT were included. PET results were interpreted based upon Deauville criteria. The prognostic value of 18 F-FDG PET/CT in auto-HSCT was evaluated.Results: Eighty-four patients were enrolled. In univariate analysis, pre-and post-HSCT PET findings were correlated with 3-year progression-free survival(PFS) [hazard ratio(HR)=4.391, P=0.001; HR=7.607, P<0.001] and overall survival(OS)(HR=4.792, P=0.008; HR=26.138, P<0.001). Patients receiving upfront auto-HSCT after firstline treatment had better outcomes than relapsed/refractory DLBCL patients(3-year PFS, P<0.001; 3-year OS,P<0.001). In the relapsed/refractory patients, pre-and post-HSCT PET findings were also associated with 3-year PFS(P=0.003 vs. P<0.001) and OS(P=0.027 vs. P<0.001). A significant correlation was observed between clinical response to chemotherapy before auto-HSCT and outcomes of patients in the entire cohort(3-year PFS, P<0.001;3-year OS, P<0.001) and in the subgroup of 21 patients with positive pre-HSCT PET(3-year PFS, P=0.084; 3-year OS, P=0.240). A significant association between survival and post-HSCT PET findings was observed in multivariate analysis(HR=5.168, P<0.001).Conclusions: PET results before and after HSCT are useful prognostic factors for DLBCL patients receiving HSCT. Patients who responded to chemotherapy, even those with positive pre-HSCT PET, are appropriate candidates for auto-HSCT. | Zhitao Ying Lan Mi Nina Zhou Xuejuan Wang Zhi Yang Yuqin Song Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu Lijuan Deng Jun Zhu | 2019 | Chinese Journal of Cancer Research2019，31，1： | 2 |
| 9 | Antiproliferative Autoantigen CDA1 Transcriptionally Up-regulates p21Waf1/Cip1 by Activating p53 and MEK/ERK1/2 MAPK Pathways 显示文摘 | Yugang Tu Weiping Wu Tieqiao Wu | 2007 | J Biol Chem2007，282，11： | 1 |
| 10 | 显示文摘 | Zhang Changhua Hu Jianqing Tu Weiping | 2006 | Journal of Shaanxi University of Science & Technology2006，24，5： | 1 |
| 11 | Antiproliferative Autoantigen CDA1 Transcriptionally Up-regulates p21Waf1/Cipl by Activating p53 and MEK/ERK1/2 MAPK Pathways显示文摘 | Yugang Tu Weiping Wu Tieqiao Wu | 2007 | J Biol Chem2007，282，11： | 1 |
| 12 | Mycophenolate Mofetil Treatment for IgA Nephropathy: A Meta-Analysis显示文摘 | Gaosi Xu Weiping Tu Dongfeng Jiang | 2009 | AmJNephrol2009，29，： | 1 |
| 13 | A mathematical model for freeze-drying显示文摘 | Tu Weiping Chen Menglin Yang Zhuoru | 2000 | 8(2):118-1222000，8，2： | 1 |
| 14 | Stable poly(glycidyl methae- rylate-eo-ethyleneglyeol dimethaerylate) microspheres via polymerization显示文摘 | Jiang Xuhong Tu Weiping | 2000 | J Polym Sei Part A: Polym Chem2000，115，2： | 1 |
| 15 | Non–high-density lipoprotein cholesterol is associated more closely with albuminuria in Chinese type 2 diabetic patients with normal renal function, compared with traditional lipid parameters显示文摘 | Jiemin Pan Fei Gao Yuqian Bao Lei Zhang Yinfang Tu Weiping Jia | 2012 | Journal of Clinical Lipidology2012，，4： | 1 |
| 16 | Mycophenolatemofetil treatment for Ig A nephropathy:A meta-analysis显示文摘 | Gaosi Xiu Weiping Tu Dongfeng Jiang | 2009 | Am J Nephrol2009，29，5： | 1 |
| 17 | Interpolation Method of Head-Related Transfer Functions Based on Common-Pole/Zero Modeling显示文摘The head-related transfer function(HRTF)involves the cues for human auditory localization,which turns it into an essential item of virtual auditory display technology.In practice,the interpolation of HRTF is necessary for the virtual auditory display systems to achieve high spatial resolution.Traditional geometric-based interpolation methods are generally restrained by the spatial distribution of reference on HRTF.When the spatial distribution is sparse,the accuracy of interpolation decreases significantly.Therefore,an interpolation method using the common-pole/zero model and the fitting neural network is proposed.First,we propose a common-pole/zero model to represent HRTFs across multiple subjects,in which the low-dimensional features of the measured HRTFs are extracted.Then,for a new spatial direction,we predict the corresponding low-dimensional HRTF with a fitting neural network.Finally,we reconstruct the high-dimensional HRTF from the predicted low-dimensional HRTF.The simulation results suggest that the proposed method outperforms other interpolation methods such as Linear_AMBC,Bilinear_AMBC,and the Combination method. | Wei Chen Xiaochen Wang Ruimin Hu Gang Li Weiping Tu | 2020 | China Communications2020，17，10： | 0 |
| 18 | Randomly coupled trench-assisted multicore fibers with different arrangements for high tolerance of manufacturing errors显示文摘Randomly coupled multicore fibers(RC-MCFs)are promising candidates for long-haul transmission.However,the degree of coupling between the homogeneous cores of an RC-MCF is weakened if manufacturing errors appear.Therefore,a low-index trench layer is introduced into the coupled cores to investigate the effects of its position and thickness on the group index to enhance the tolerance of manufacturing errors.A depressed region is designed in the center of the core to solve the problem of the effective area decreasing because of the confinement of the low-index trench.Additionally,it is important to study the effective arrangement of the coupled cores to obtain a smaller group delay spread(GDS)within the limited 125-μm cladding;we discuss the single-layer and double-layer arrangements.A moderate range is found for both the bending radius and core pitch to minimize the GDS.For the single-layer arrangement,the degree of mixing is weak,and the degeneracy state does not easily change the bending conditions;thus,it may be a good candidate for designing systemically coupled multicore fibers.For the double-layer arrangement,the bending and twisting factors can induce sufficient mixing among the different modes to reduce GDS;thus,this arrangement is more suitable for the design of RC-MCFs. | Yongneng JIANG Jiajing TU Shecheng GAO Weiping LIU Zhaohui LI | 2023 | Science China(Information Sciences)2023，66，11： | 0 |
| 19 | Primary gastrointestinal mantle lymphoma with massive bleeding: a case report and literature review显示文摘The incidence of primary gastrointestinal lymphomas (PGILs) has been increasing. The clinical presentation and treatment of PGIL are distinct from those of nodular lymphomas. Symptoms include abdominal pain, abdominal mass, changes in bowel habits, obstruction, and bleeding. Less life-threatening gastrointestinal bleeding occurs after chemotherapy and few reports have focused on the bleeding of PGILs. We report a case of severe gastrointestinal bleeding caused by low-dose chemotherapy, which was dramatically improved by rituximab monotherapy treatment. The prevention and treatment of gastrointestinal bleeding in PGIL should be given much attention. | Wen Zheng Yuqin Song Ningjing Lin Meifeng Tu Weiping Liu Jun Zhu | 2013 | Chinese Journal of Cancer Research2013，25，2： | 0 |
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