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| 1 | Dissection of genetic overlap of salt tolerance QTLs at the seedling and tillering stages using backcross introgression lines in rice显示文摘QTLs for salt-tolerance(ST)related traits at the seedling and tillering stages were identified using 99 BC2F8 introgression lines(IL)derived from a cross between IR64(indica)as a recurrent parent and Binam(japonica)from Iran as the donor parent.Thirteen QTLs affecting survival days of seedlings(SDS), score of salt toxicity of leaves(SST),shoot K + concentration(SKC)and shoot Na + concentration(SNC) at the seedling stage and 22 QTLs underlying fresh weight of shoots(FW),tiller number per plant(TN) and plant height(PH)at the tillering stage were identified.Most QTLs detected at the tillering stage showed obvious differential expression to salt stress and were classified into three types based on their differential behaviors.Type I included 11 QTLs which were expressed only under the non-stress condition.Type II included five QTLs expressed in the control and the salt stress conditions,and three of them(QPh5,QPh8 and QTn9)had similar quantity and the same direction of gene effect,suggesting their expression was less influenced by salt stress.Type III included six QTLs which were detectable only under salt stress,suggesting that these QTLs were apparently induced by the stress.Thirteen QTLs affecting trait difference or trait stability of ILs between the stress and non-stress conditions were identified and the Binam alleles at all loci except QPh4,QTn2 and QFw2a decreased trait difference.The three QTLs less influenced by the stress and 13 QTLs affecting trait stability were considered as ST QTLs which contributed to ST.Comparing the distribution of QTLs detected at the seedling and tillering stages,most(69%)of them were genetically independent.Only four were the same or adjacent regions on chromosomes 1,2,8 and 11 harboring ST QTLs detected at the two stages,suggesting that partial genetic overlap of ST across the two stages occurs.It is likely,therefore,to develop ST rice variety for both stages by pyramiding of ST QTLs of different stages or selection against the overlapping QTLs between the two stages via marker-assisted selection(MAS). | ZANG JinPing 1 ,SUN Yong 1 ,WANG Yun 1 ,YANG Jing 1 ,LI Fang 1 ,ZHOU YongLi 1 ,ZHU LingHua 1 , Reys JESSICA2,Fotokian MOHAMMADHOSEIN 2,XU JianLong 1&LI ZhiKang 1,2 1Institute of Crop Sciences/National Key Facility for Crop Gene Resources&Genetic Improvement,Chinese Academy of Agricul- tural Sciences,Beijing 100081,China 2International Rice Research Institute,DAPO Box 7777,Metro Manila,Philippines | 2008 | Science China(Life Sciences)2008，51，7： | 32 |
| 2 | Clinicopathological features and outcomes of patients with gastric cancer:A single-center experience显示文摘AIM:To evaluate the location,histopathology,stages,and treatment of gastric cancer and to conduct survival analysis on prognostic factors.METHODS:Patients diagnosed with of stomach cancer in our clinic between 2000 and 2011,with follow-up or a treatment decision,were evaluated retrospectively.They were followed up by no treatment,adjuvant therapy,or metastatic therapy.We excluded from the study any patients whose laboratory records lacked the operating parameters.The type of surgery in patients diagnosed with gastric cancer was total gastrectomy,subtotal gastrectomy or palliative surgery.Patients with indications for adjuvant treatment were treated with adjuvant and/or radio-chemotherapy.Prognostic evaluation was made based on the parameters of the patient,tumor and treatment.RESULTS:In this study,outpatient clinic records of patients with gastric cancer diagnosis were analyzed retrospectively.A total of 796 patients were evaluated(552male,244 female).The median age was 58 years(22-90 years).The median follow-up period was 12 mo(1-276 mo),and median survival time was 12 mo(11.5-12.4 mo).Increased T stage and N stage resulted in a decrease in survival.Other prognostic factors related to the disease were positive surgical margins,lymphovascular invasion,perineural invasion,cardio-esophageal settlement,and the levels of tumor markers in metastatic disease.No prognostic significance of the patient's age,sex or tumor histopathology was detected.CONCLUSION:The prognostic factors identified in all groups and the proposed treatments according to stage should be applied,and innovations in the new targeted therapies should be followed. | Fatih Selcukbiricik Evin Buyukunal Deniz Tural Mustafa Ozguroglu Fuat Demirelli Suheyla Serdengecti | 2013 | World Journal of Gastroenterology2013，19，14： | 7 |
| 3 | Clinical efficacy and drug resistance of anti-epidermal growth factor receptor therapy in colorectal cancer显示文摘Colorectal cancer(CRC) ranked third in cancer related death and its incidence has been increasing worldwide. In recent decades important therapeutic advances have been developed in treatment of metastatic CRC(mCRC), such as monoclonal antibodies against epidermal growth factor receptor(anti-EGFR), which provided additional clinical benefits in mCRC. However, anti-EGFR therapies have limited usage due to approximately 95% of patients with KRAS mutated mCRC do not response to anti-EGFR treatment. Thus, KRAS mutation is predictive of nonresponse to anti-EGFR therapies but it alone is not a sufficient basis to decide who should not be received such therapies because; approximately fifty percent(40%-60%) of CRC patients with wild-type KRAS mutation also have poor response to anti-EGFR based treatment. This fact leads us to suspect that there must be other molecular determinants of response to anti-EGFR therapies which have not been identified yet. Current article summarizes the clinical efficacy of anti-EGFR therapies and also evaluates its resistance mechanisms. | hakan kocoglu fatih mehmet velibeyoglu mustafa karaca deniz tural | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 4 |
| 4 | Registered and enrolled nurses'experiences of ethical issue in nursing practice显示文摘 | Johnston M J Costa CD Turale S | 2004 | Australian Journal of Advanced Nursing2004，22，1： | 1 |
| 5 | Primary gastric lymphoma:eonservative treatment modality is not inferior to surgery for early-stage disease 显示文摘 | Selcukbiricik F Tural D Elicin O | 2012 | ISRN Oncol2012，2012，95： | 1 |
| 6 | Psychological consequences of the 1999 earthquake in Turkey显示文摘 | Tural U Coskun B Onder E | 2004 | Trauma Stress2004，17，： | 1 |
| 7 | The relation between pathological complete response and clinical outcome in patients with rectal cancer 显示文摘 | Tural D Selcukbiricik F /:zturk MA | 2013 | Hepatogastmenterology2013，60，126： | 1 |
| 8 | Assessing the severity of panic and agoraphobia: validity, reliability and objectivity of the Turkish translation of the Panic and Agoraphobia Scale (P&A)显示文摘 | Tural U Fidaner H Alkn T | 2002 | Journal of Anxiety Disorder2002，16，： | 1 |
| 9 | Perineural invasion inde- pendent prognostic factors in patients with gastric cancer undergoing curative resection显示文摘 | Selqukbiricik F Tural D Btiytiktinal E | 2012 | Asian Pac J Cancer Prev2012，13，7： | 1 |
| 10 | Crystal Structure and Characterzation of a New Copper-ciprofloxzcin of Comples显示文摘 | Tural I Golic L Ruiz R O | 1999 | J Acta Chem Slov1999，46，： | 1 |
| 11 | Psychological consequences of the 1999 earthquake in Turkey 显示文摘 | Tural U Coskun B Onder E | 2004 | J Trauma Stress2004，7，6： | 1 |
| 12 | Psychological consequences of the 1999 earthquake in Turkey显示文摘 | Tural U Coskun B Onder E | 2004 | J Trauma Stress2004，17，6： | 1 |
| 13 | An eth nographic study of diabetes health beliefs and practices in Sri Lankan adults显示文摘 | Amarasekara A Fongkaew W Turale S | 2014 | Int Nurs Rev2014，61，50： | 1 |
| 14 | Preparation and characterization of polymer coated superparamagneticmagnetite nanoparticle agglomerates 显示文摘 | Tural B Ozkan N Voikan M | 2009 | Journal of Physics and Chemistry of Solids2009，70，： | 1 |
| 15 | Web based real-time meteorological data analysis and mapping information system显示文摘 | REFIK SAMET SERHAT TURAL | | 0，，04： | 1 |
| 16 | Association between osteo- porosis and polymorphisms of the IL-10 and TGF-beta genes in Turkish postmenopausal women 显示文摘 | Tural S Alayli G Kara N | 2013 | Hum Immu- nol2013，74，9： | 1 |
| 17 | Clinical significance of p95HER2 overexpresslon, PTEN loss and PI3K expression in p185HER2- positive metastatic breast cancer patients treated with trastuzumab- based therapies 显示文摘 | Buyukunal D Tural S | 2014 | British Journal of Cancer2014，110，8： | 1 |
| 18 | Foot drop:the first sign of an intracranial tumor显示文摘 | Tural S Konya D | | 0，，： | 1 |
| 19 | Psychological consequences of the 1999 earthquake in Turkey 显示文摘 | Tural U Coskun B Onder E | 2004 | J Trauma Stress2004，17，6： | 1 |
| 20 | Nurses' experiences of ethical preparedness for public health disasters: a systematic review of emergencies and healthcare qualitative evidence 显示文摘 | Johnstone MJ Turale S | 2014 | Nurs Health Sci2014，16，1： | 1 |
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