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| 1 | Clinical outcomes of lung metastasectomy in patients with colorectal cancer显示文摘AIM:To investigate prognostic factors of survival following curative,non-palliative surgical removal of lung metastases secondary to colorectal cancer (CRC).METHODS:Between 1999 and 2009,a radical metastasectomy with curative intent was performed on lung metastases in 21 patients with CRC (15 male and 6 female;mean age:57.4 ± 11.8 years;age range:29-74 years) who had already undergone primary tumour resection.RESULTS:The mean number of lung metastases ranged from one to five.The mean overall survival was 71 ± 35 mo (median:25 mo).After adjusting for potential confounders,multivariable Cox regression analyses predicted only the number of lung metastases (1 vs ≥ 2;hazard ratio:7.60,95% confidence interval:1.18-17.2,P=0.03) as an independent predictor of poor survival following lung resection for metastatic CRC.CONCLUSION:Resection of lung metastases is a safe and effective treatment in selected CRC patients with single lung metastases. | Omer Fatih Olmez Erdem Cubukcu Ahmet Sami Bayram Unsal Akcali Turkkan Evrensel Cengiz Gebitekin | 2012 | World Journal of Gastroenterology2012，18，7： | 3 |
| 2 | Cytotoxic, genotoxic and apoptotic effects of naringenin-oxime relative to naringenin on normal and cancer cell lines显示文摘Objective: To assess and compare the cytotoxic, genotoxic, apoptotic and reactive oxygen species(ROS) generating effects of naringenin(NG) and its new derived compound naringenin-oxime(NG-Ox) on MCF-7, HT-29, PC-12 cancer and L-929 normal cell lines.Methods: The cells were incubated with different doses of NG-Ox and NG(50–1 000 mmol/L) for 24 h. The cell viability was assessed based on ATP cell viability assay.Intracellular accumulation of ROS was determined using the fluorescent probes 2070-dichlorodihydrofluorescin diacetate. Genotoxic effects were evaluated by alkaline single cell gel electrophoresis assay(comet assay) and, the apoptotic effect was evaluated by acridine orange staining at below the IC50 levels.Results: Both NG-Ox and NG exhibited cytotoxic, genotoxic and apoptotic effects and resulted in increased ROS values in a dose-dependent manner. The effects were more pronounced on cancer cell lines. The cytotoxic, genotoxic and apoptotic effects of NG-Ox were higher than that of NG in all cell lines. Significant correlations were observed between cell viability, DNA damage, apoptosis and ROS, in all cell lines exposed to either NG-Ox or NG.Conclusions: This study showed that both NG-Ox and NG possess cytotoxic, genotoxic and apoptotic activities through the production of ROS on cells, NG-Ox being the more effective one. Therefore, derived compound of NG might be used as antiproliferative agents for the treatment of cancer. | Abdurrahim Kocyigit Ismail Koyuncu Murat Dikilitas Fatemeh Bahadori Baki Turkkan | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，10： | 2 |
| 3 | Experimental determination of wind pressure distribution for cylindrical and spherical flexible mem- brane structures显示文摘 | Turkkan N Srivastava N K | 1995 | Canadian Journal of Civil Engineering1995，22，1： | 1 |
| 4 | Helicobacter pylori infection in Turkish children with gastrointestinal symptoms and evaluation of serology显示文摘 | Sokucu S Suoglu OD Turkkan E | 2002 | Turk J Pediatr2002，44，5： | 1 |
| 5 | Citicoline and postconditioning provides neuroprotection in a rat model of ischemic spinal cord injury显示文摘 | Turkkan A Alkan T Goren B | | 0，，06： | 1 |
| 6 | Does Helicobacter pylor- rinduced inflammation of gastric mucosa determine the severity of symptoms in functional dyspepsia 显示文摘 | Turkkan E Uslan I Acarturk G | 2009 | J Gastroenterol2009，44，1： | 1 |
| 7 | Distribution of the linear combination of two general beta variables and applications 显示文摘 | Pham-Gia T Turkkan N | 1998 | Communications in Statistics - Theory and Methods1998，27，7： | 1 |
| 8 | Soivong the forward kinematics of parallel manipulators with a genetic algorithm显示文摘 | Boudreau R Turkkan N | 1993 | J Robotic System1993，13，2： | 1 |
| 9 | Citicoline and postconditioning provides neuroprotection in a rat model of ischemic spinal cord injury 显示文摘 | Turkkan A Alkan T Goren B | 2010 | Acta Neurochir (Wien)2010，152，6： | 1 |
| 10 | Solving the tbrward kinemat- ics of parallel manipulators with a genetic algorithm 显示文摘 | BOUDREAU R TURKKAN N | 1996 | Jour-nal of Robotic Systems1996，13，2： | 1 |
| 11 | The Lorenz and the scaled total-time-on-test transform curves: a unified approach显示文摘 | Pham T G Turkkan N | 1994 | IEEE Transactions on Reliability1994，43，1： | 1 |
| 12 | Solving the for- ward kinematics o'f parallel manipulators with a ge- netic algorithm 显示文摘 | Boudreau Roger Turkkan Noyan | 1996 | Journal of Robotic Systems1996，13，2： | 1 |
| 13 | Distribution of the linear combination of two general beta variables and applications 显示文摘 | PHAM G T TURKKAN N | 1998 | Commun Statist-Theory Meth1998，27，7： | 1 |
| 14 | Occupational lead ex-posure:blood lead levels of apprentices in BursaTurkey显示文摘 | Pala JK Turkkan A Gucer S | 2009 | Ind Health2009，47，1： | 1 |
| 15 | Solving the Forward Kinematics of Parallel Manipulators with a Genetic Algorithm显示文摘 | Boudreau R Turkkan N | | 0，，02： | 1 |
| 16 | Solving the forward kinematics of parallel manipulators with a genetic algorithm显示文摘 | Boudreau R Turkkan N | 1996 | Robotic Systems1996，13，2： | 1 |
| 17 | Distribution of the linear combination of two general beta variables and applications 显示文摘 | PHAM G T TURKKAN N | 1998 | Commun Statist-Theory Meth1998，27，7： | 1 |
| 18 | Solving the Forward Kinematics of Parallel Manipulators with a Genetic Algorithm 显示文摘 | Boudreau R Turkkan N | 1996 | Journal of Robotics Systems1996，13，2： | 1 |
| 19 | Solving the forward kinematics of parallel manipulators with a genetic algorithm 显示文摘 | Boudreau R Turkkan N | 1996 | Journal of Robotic Systems1996，13，2： | 1 |
| 20 | Bounds for The Bayes Error in Classification: A Bayesian Approach Using Discriminant Analysis 显示文摘 | Pham-Gia T Turkkan N Bekker A | 2007 | Statistical Methods and Applications2007，，16： | 1 |
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