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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 3 | Performance of Neural Network: Mapping Forests Using GIS and Remotely Sensed Data 显示文摘 | Skidmore A Turner B Brinkhof W Knowles E | 1997 | ISPRS Journal of Photogrammetric Engineering & Remote Sensing1997，63，： | 2 |
| 4 | Relationships between leaf area index, FAPAR and net primary production of terrestrial ecosystems 显示文摘 | Turner 15 P Cohen W B Kennedy R E et el | 1999 | Remote Sensing of Enviroment1999，70，： | 1 |
| 5 | Consequences of the 1993 Mississippi River flood in the Gulf of Mexico显示文摘 | Rabalais N N Turner R E Wiseman W J | 1998 | Regulated Rivers Res Manage1998，14，： | 1 |
| 6 | Broad-spectrum virus re- sistance in transgenic p]ants expressing pokeweed antivind protein 显示文摘 | Lodge J K Kaniewaki W K Turner N E | 1993 | Proc Nail Acad Sci USA1993，90，： | 1 |
| 7 | A novel method of automated skull registration for forensic facial approximation显示文摘 | TURNER W D BROWN R E KELLIHER T P | 2005 | Forensic Science International2005，154，23： | 1 |
| 8 | Modeling land use and cover as a part of global environmental change显示文摘 | Meyer W B and Turner Ⅱ B L | 1994 | Climate Change1994，，28： | 1 |
| 9 | Modeling land use and cover as part of global environmental change显示文摘 | Riebsame W E Meyer W B Turner B L | 1994 | Climatic Change1994，28，： | 1 |
| 10 | 查看详情显示文摘 | Turner N W Wright B E Hlady V Britt D W | | 0，，： | 1 |
| 11 | Nutrient changes in the Mississipi River and system responses on the adjacent continental shelf 显示文摘 | RABALAIS N N WISEMAN W J TURNER R E | 1996 | Estuaries1996，19，： | 1 |
| 12 | 查看详情显示文摘 | Matthews D L Campbell E M Ceglio N M Hermes G Kauffman R Koppel L Lee R Manes K Rupert V Slivinsky W Turner R Ze F | | 0，，： | 1 |
| 13 | Proposed mechanisms on how Cavendish bananas are predisposed to Fusarium wilt during hypoxia显示文摘 | Aguilar E A Turner D W SivasithamPamm K | 2000 | Infomusa2000，9，2： | 1 |
| 14 | A mathematical procedure for estimating animal growth and body composition显示文摘 | Bridges T C Turner L W Smith E M | 1986 | Transactions of the American Association of Agricultural Engineers1986，29，： | 1 |
| 15 | Studies on the phosphorylation of LY303366显示文摘 | Udodong U E Turner W W Astleford B A | 1998 | Tetrahedron Lett1998，39，34： | 1 |
| 16 | Relationship Between Leaf Area Index and Landsat TM Spectral Vegetation Indices Across Three Temperate Zone Sites显示文摘 | Turner D P Cohen W B Kennedy R E | 1999 | Remote Sensing of Environment1999，70，： | 1 |
| 17 | Modeling land ise and cover as part of global environmental change显示文摘 | Riebsame W E Meyer W B Turner B L | 1994 | Climate Change1994，28，： | 1 |
| 18 | Estuarine influences on a continental shelf plankton community显示文摘 | TURNER R E S WOO W JITTS H R | 1979 | Science1979，206，： | 1 |
| 19 | Volatile compound content and fatty acid composition of pork as influenced by linoleic acid content of the diet 显示文摘 | Larick D K Turner B E Schoenherr W D | 1992 | Journal of Animal Science1992，70，5： | 1 |
| 20 | Two types of global environmental change:Definitional and spatial-scale issues in their human di-mensions显示文摘 | Turner B L Kasperson R E Meyer W B | 1990 | Global Environmental Change1990，1，1： | 1 |
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