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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet . 2004 (9435)2004，，9435： | 1 |
| 3 | Delta tryptase is expressed in multiple human tissues, and a recombinant form has proteolytie activity 显示文摘 | Wang H W Mc Neil H P Husain A | 2002 | Journal of Immunology2002，169，9： | 1 |
| 4 | Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS:23)显示文摘 | Turner R C Millns H Neil H A W | 1998 | BMJ1998，318，： | 1 |
| 5 | Comparison of soluble manganese and acidic potassium permanganate chemiluminence detection using flow injection and sequential injection analysis for the determination of ascorbic acid in vitamin C tablets 显示文摘 | Nicole A Neil W B Benjamin J H | 2004 | Talanta2004，64，1： | 1 |
| 6 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 7 | The relationship between dietary flavonol intake and coronary heart disease mortality: A meta-analysis of prospective cohort studies显示文摘 | HUXLEY R R NEIL H A W | 2003 | European Journal of Clinical Nutrition2003，57，8： | 1 |
| 8 | Association of Systolic Blood Pressure with Macrovascular and Microvascular Complication of Type 2 Diabetes(UKPDS 36):Prospective Observational Study显示文摘 | Amanda I A Stratton I M Neil H A W | 2000 | British Medical Journal2000，321，： | 1 |
| 9 | Association of systolic blood pressure with macrovascular and microvascular complication of type 2 diabetes (UKPDS36) : prospective observational study 显示文摘 | ADLER A I STRATON I M NEIL H A W | 2000 | B M J2000，321，： | 1 |
| 10 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet2004，，9435： | 1 |
| 11 | Effects of water temperature and dissolved oxygen on daily feed consumption,feed utilization and growth of channel catfish (Ictalurus puntactus)显示文摘 | Buentello J A Gatlin D M III Neil W H | 2000 | Aquaculture2000，182，： | 1 |
| 12 | Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus 显示文摘 | Nierman WC Pain A Anderson MJ Wortman JR Kim HS Arroyo J Berriman M Abe K Archer DB Bermejo C Bennett J Bowyer P Chen D Collins M Coulsen R Davies R Dyer PS Farman M Fedorova N Fedorova N Feldblyum TV Fischer R Fosker N Fraser A Garcla JL Garcia MJ Goble A Goldman GH Gomi K Griffith- Jones S Gwilliam R Haas B Haas H Harris D Horiuchi H Huang J Humphray S Jim6nez J Keller N Khouri H Kitamoto K Kobayashi T Konzack S Kulkarni R Kumagai T Lafon A Latgo JP Li W Lord A Lu C Majoros WH May GS Miller BL Mohamoud Y Molina M Monod M Mouyna I Mulligan S Murphy L O'Neil S Paulsen I Pefialva MA Pertea M Price C Pritchard BL Quail MA Rabbinowitsch E Rawlins N Rajandream MA Reichard U Renauld H Robson GD Rodriguez de Cordoba S Rodriguez-Pefia JM Ronning CM Putter S Salzberg SL Sanchez M Sfnchez-Ferrero JC Saunders D Seeger K Squares R Squares S Takeuchi M Tekaia F Turner G Vazquez de Aldana CR Weidman J White O Woodward J Yu JH Fraser C Galagan JE Asai K Machida M Hall N Barrell B Denning DW | 2005 | Nature2005，438，7071： | 1 |
| 13 | Association of glycaemia with macrovascular and micravascular complications of type 2 diabetes (UKPDS 35):Prospective observations study显示文摘 | Stratton I M Adler A I Neil H A W | 2000 | BMJ2000，321，： | 1 |
| 14 | Pavement Distress Evaluation Using Fuzzying Logic and Moment Invariants显示文摘 | CHOU J C O'NEIL W A CHENG H D | 1995 | Transportation Research Record1995，，1505： | 1 |
| 15 | Risk factor for coronary artery disease in non-insulin dependent diabetes mellitus:United Kingdom Prospective Diabetes Study (UKPDS:23)显示文摘 | Tumor R C Millis H Neil H A W | 1998 | BMI1998，318，： | 1 |
| 16 | Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus (UKPDS 23) 显示文摘 | TURNER R C MILLNS H NEIL H A W | 1998 | BMJ1998，31，： | 1 |
| 17 | The relationship between dietary flavonol intake and coronary heart disease mortality:a meta-analysis of prospective cohort studies显示文摘 | HUXLEY R R NEIL H A W | | 0，，08： | 1 |
| 18 | Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes ( UKPDS 35 ) : prospective observational study 显示文摘 | Stratton I M Adler A I Neil H A W | 2000 | Bmj2000，321，7258： | 1 |
| 19 | Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes ( UKPDS 35 ) : prospective observational study显示文摘 | STRATTON I M ADLER AI NEIL H A W | 2000 | BMJ2000，321，7258： | 1 |
| 20 | Randomised controlled trial of use by hypercholesterolaemic patients of a vegetable oil sterolenriched fat spread显示文摘 | Neil H A Meijer G W Roe L S | 2001 | Atherosclerosis2001，156，： | 1 |
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