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| 1 | Structural and Functional Analysis of NS1 and NS2 Proteins of H1N1 Subtype显示文摘Influenza A virus (H1N1), a genetic reassortment of endemic strains of human, avian and swine flu, has crossed species barrier to human and apparently acquired the capability of human to human transmission. Some strains of H5N1 subtype are highly virulent because NS1 protein inhibits antiviral interferon α/β production. Another protein NS2 mediates export of viral ribonucleoprotein from nucleus to the cytoplasm through export signal. In this paper, we have studied structure-function relationships of these proteins of H1N1 subtype and have determined the cause of their pathogenicity. Our results showed that non-conservative mutations slightly stabilized or destabi- lized structural domains of NS1 or NS1-dsRNA complex, hence slightly increased or decreased the function of NS1 protein and consequently enhanced or reduced the pathogenicity of the H1N1 virus. NS2 protein of different strains carried non-conservative mutations in different domains, resulting in slight loss of function. These mutations slightly decreased the pathogenicity of the virus. Thus, the results confirm the structure-function relationships of these viral proteins. | Parveen Salahuddin Asad U.Khan | 2010 | Genomics, Proteomics & Bioinformatics2010，8，3： | 5 |
| 2 | Bi-metallic catalysts of mesoporous Al_2O_3 supported on Fe, Ni and Mn for methane decomposition: Effect of activation temperature显示文摘Methane decomposition reaction has been studied at three different activation temperatures(500°C,800°C and950°C)over mesoporous alumina supported Ni–Fe and Mn–Fe based bimetallic catalysts.On co-impregnation of Ni on Fe/Al_2O_3the activity of the catalyst was retained even at the high activation temperature at 950°C and up to180 min.The Ni promotion enhanced the reducibility of Fe/Al_2O_3oxides showing higher catalytic activity with a hydrogen yield of 69%.The reactivity of bimetallic Mn and Fe over Al_2O_3catalyst decreased at 800°C and 950°C activation temperatures.Regeneration studies revealed that the catalyst could be effectively recycled up to 9times.The addition of O_2(1 ml,2 ml,4 ml)in the feed enhanced substantially CH_4conversion,the yield of hydrogen and the stability of the catalyst. | Anis H.Fakeeha Ahmed S.Al-Fatesh Biswajit Chowdhury Ahmed A.Ibrahim Wasim U.Khan Shahid Hassan Kasim Sasudeen Ahmed Elhag Abasaeed | 2018 | Chinese Journal of Chemical Engineering2018，26，9： | 3 |
| 3 | Catalytically active interfaces in titania nanorod-supported copper catalysts for CO oxidation显示文摘One-dimensional titanium dioxide nanorod(TNR)-supported Cu catalysts(2.5 wt.%-12.5 wt.%)were synthesized using deposition-precipitation.X-ray photoelectron spectroscopy,temperature programmed reduction and CO chemisorption measurements showed that Cu doping over TNR offered metal-support interactions and interfacial active sites that had a profound impact on the catalytic performance.The role of the Cu-TNR interface was investigated by comparing the catalytic activity of Cu-TNR catalysts with that of pure CuO nanoparticles in CO oxidation.The presence of highly dispersed copper species,a high number of interfacial active sites,CO adsorption capacity and surface/lattice oxygen were found to be responsible for the excellent activity of 7.5CU-TNR(ie,Cu loading of 7.5 wt.%on TNR).Moreover,the Cu-TNR catalysts followed the Langmuir-Hinshelwood reaction mechanism with 7.5CU-TNR,exhibiting an apparent activation energy of 44.7 kJ/mol.The TNR-supported Cu catalyst gave the highest interfacial catalytic activity in medium-temperature CO oxidation(120-240℃)compared to other commonly used supports,including titanium dioxide nanoparticles(TiO2-P25),silica(SiO2)and alumina(Al20g)in which copper species were nonhomogeneously dispersed.This study confirms that medium-temperature CO oxidation is highly sensitive to the morphology and structure of the supporting material. | Wasim U.Khan Season S.Chen Daniel C.W.Tsang Wey Yang Teoh Xijun Hu Frank L.Y.Lam Alex C.K.Yip | 2020 | Nano Research2020，13，2： | 2 |
| 4 | 查看详情显示文摘 | J.N.Coleman M.Lotya A.O'Neill S.D.Bergin P.J.King U.Khan K.Young A.Gaucher S.De R.J.Smith I.V.Shvets S.K.Arora G.Stanton H.Y.Kim K.Lee G.T.Kim G.S.Duesberg T.Hallam J.J.Boland J.J.Wang J.F.Donegan J.C.Grunlan G.Moriarty A.Shmeliov R.J.Nicholls J.M.Perkins | | 0，，： | 1 |
| 5 | Implication of 14-3-3ζ-BDNF pathway in long-lasting memory enhancement and the rescue from memory deficits显示文摘Intact memory function is critical for carrying out daily life activities,such as managing finances,remembering to take medications,driving in familiar environments,remembering a grandchild’s birthday,and learning to use a new computer.However,memory deficits not only accompany normal aging but are also comorbid with many psychiatric,neurological,and neurodegenerative diseases.Intellectual disability,autism,attention deficit disorder,learning disability,schizophrenia,and depression all have memory deficit components,as do Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and other neurodegenerative diseases(Khan et al.,2014).Therefore,a large proportion of the human population is affected by this brain disorder. | Mariam Masmudi-Martín Irene Navarro-Lobato Zafar U.Khan | 2022 | Neural Regeneration Research2022，17，12： | 1 |
| 6 | Synthesis,photoluminescence properties and thermal investigation by TG-MS of RE(DAS)3·xH2O(RE=Eu3+,Tb3+)显示文摘Rare earth(Ⅲ)diphenyl-4-amine sulfonates(RE(DAS)3·xH2O,RE=Eu^3+,Tb^3+)phosphors were synthesized by precursor method from barium diphenyl-4-amine sulfonate and rare earth sulfates.FTIR,TG/DSC coupled to mass spectrometry(TG/DSC/MS),X-ray powder diffraction(XPD),scanning electron microscopy(SEM)and photo luminesce nce(PL)spectroscopy were utilized to structurally and morphologically characterize the samples.Thermal decomposition of Eu(DAS)3·7H2O and Tb(DAS)3·2H2O at 973 K under dynamic air atmosphere results in crystalline Eu2O2SO4 and Tb2O2SO4 materials,respectively.Accordingly,MS spectra reveal the liberation of thermal decomposition products of precursors,largely as CO2,NO2 and SO2 gases.The diphenyl-4-amine sulfonate(DAS)ligand demonstrats a good stabilizing property for Eu^3+and Tb^3+ions.The Eu(DAS)3·7H2O and Tb(DAS)3·2H2O compounds display efficient red and green emissions,under UV excitation,arising from the 5D0→7FJ(J=0-4)and 5D4→7FJ(J=0-6)transitions of the Eu^3+and Tb^3+ions,respectively. | Rodrigo V.Rodrigues Lukasz Marciniak Latif U.Khan Antonio A.L.Marins Robert Tomala Emanuel J.B.Muri Jivaldo R.Matos Wieslaw Strek | 2019 | Journal of Rare Earths2019，37，11： | 0 |
| 7 | Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents显示文摘Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to produce satisfa ctory effects.Therefore,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of ORM.In this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s disease.Furthermore,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM deficits.These findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s disease.Therefore,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits. | Irene Navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan | 2024 | Neural Regeneration Research2024，19，8： | 0 |
| 8 | Ribozymes:an anti-viral agent显示文摘The discovery that RNA can act as an enzyme led Thomas Cech to win the Nobel Prize in Chemistry and led immediately to the next wave of attempts to find an effective RNA-based therapy.The tantalizing idea that RNA enzymes called trans-cleaving ribozymes enables them to act as potential antiviral and powerful tool for functional genomic studies.The efficacy of ribozyme function in a complex intracellular environment is dependent on the intracellular fate of the RNA that is being targeted.Recently,ribozymes have been used successfully to inhibit gene expression in a variety of biological systems in vitro and in vivo.Ribozyme has also been used successfully to combat many cases of viral infection,as clinical trial.Despite it needs to be investigated and explored as far as its structural and functional aspects are concern.In view of the significance of ribozyme in modern medicine,we reviewed the recent literature on general approach to control viral infection. | Asad U.Khan Shahper N.Khan | 2008 | Asian Pacific Journal of Tropical Medicine2008，1，2： | 0 |
| 9 | 纳米ZnTe插层对Cu_(2-x)Se硫属化合物热电性能的增强效应(英文)显示文摘由于具有复杂的晶体结构和超离子导体行为,金属硫属化合物特别是Cu2-xSe在热电领域得到了广泛的关注.本文报道了一种简单易行的提高热电效率的方法:在基体材料Cu2-xSe中添加纳米Zn Te插层,用来提高Cu2-xSe材料的热电性能.实验结果表明,Cu2-xSe-Zn Te复合材料的电导率提高了32%,电导率的增加牺牲了塞贝克系数,导致复合材料的功率因子稍微低于纯Cu2-xSe基体材料;第二相的引入抑制了晶格热扩散,使得Cu2-xSe-Zn Te复合材料的热导率降低了34%.由此可知,适中的功率因子和较低的热导率致使含有10 wt.%Zn Te的Cu2-xSe-Zn Te复合材料在中温条件(750 K)下的z T值提高至0.40,相比于纯Cu2-xSe基体材料该数值提高了40%.因此,向Cu2-xSe材料中添加纳米Zn Te插层,是提高Cu2-xSe基材料热电性能的一个有效途径. | Muhammad Umer Farooq Sajid Butt 高克玮 孙喜贵 庞晓露 Asif Mahmood Waqar Mahmood Sajid U.Khan Nasir Mahmood | 2016 | Science China Materials2016，0，2： | 0 |
| 10 | Analysis of diabetic foot ulcers in a tertiary care hospital-a clinico-microbiological perspective显示文摘Objective:To assess potential risk factors for diabetic foot ulcers infected with multidrug-resistant-organisms(MDROs)and to investigate antibiotic susceptibility patterns and extended-spectrum-β-lactamase(ESBL)-production in bacteria isolated from these ulcers.Methods:Seventy-seven diabetic foot ulcer-patients were studied in a consecutive series.Forty-four study factors were recorded for each patient.Specimens were obtained by scraping the ulcer base or the deep portion of the wound edge with a sterile curette.The soft tissue specimens were quickly sent to the laboratory and processed for microbial pathogens.Gram-negative bacterial isolates were tested for ESBL production by double-disc-diffusion method.The association of study variables with MDRO and non-MDRO infection status of ulcers was tested by Student's t test or Fisher's exact test using SPSS(version 11.5,Chicago).Results:An alarming number of patients were MDRO-positive(72.7%).ESBL-positive strains constituted 19.8% of total isolates.Staphylococcal isolates identified as methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Staphylococcus aureus(VRSA),were 3.7%(n=8)and 0.5%(n=1)respectively.Twenty-two study factors were found to be significantly associated with MDRO infection status of ulcers in the univariate analysis.Multiple logistic regressions proved that MDRO status was the only significant,independent predictor of glycemic control(Odds ratio = 4.22,P<0.01).Conclusion:It is concluded that MDRO infected patients have poor glycemic control.Imipenem and linezolid can be suggested as the drugs of choice in the described setting. | Shazi Shakil Shaista Alvi Mujahid Beg Asad U.Khan | 2010 | 海南医学院学报2010，16，2： | 0 |
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