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| 1 | Association between tear film break up time and blink interval in visual display terminal users显示文摘AIM:To investigate the association between tear film break up time(TBUT)and blinking interval in visual display terminal(VDT)users.METHODS:Nine hundred and thirty VDT users underwent dry eye testing,and functional visual acuity(FVA)test.The blinking interval during FVA was compared with TBUT.Subjects with longer blinking interval than TBUT were considered as unstable tear film.Logistic regression analysis revealed the risk factors for unstable tear group.RESULTS:Among 930 workers,858 subjects(92.3%)participated in this study.Almost 80% of the subjects were categorized into the unstable tear group.Unstable tear group has significantly lower Schirmer values and TBUT(17.5±11.6 vs 21.1±11.5 mm,3.7±2.6 vs 5.7±2.7s,both P<0.001).There were no significant differences in epithelial staining or severity of symptoms.Logistic regression showed that over 40y was a risk for being unstable tear group[odds ratio(OR)=1.53;95%confidence interval(CI)=1.06-2.20].Contact lens use was protective factor for being in the unstable tear group(OR=0.37;95%CI=0.26-0.53).CONCLUSION:Subjects with shorter TBUT than blinking interval are prevalent among VDT users.Subjects over the age of 40 shows an increased risk for unstable tear film. | Miki Uchino Motoko Kawashima Yuichi Uchino Kazuo Tsubota Norihiko Yokoi | 2018 | International Journal of Ophthalmology(English edition)2018，11，10： | 5 |
| 2 | Gender differences in adolescent dry eye disease:a health problem in girls显示文摘AIM: To evaluate the signs and symptoms of dry eye disease(DED) in adolescents. METHODS: This was a cross-sectional, case-control study and outpatients aged 10 to 19y were recruited from six eye clinics of various practices and locations in Japan, and 253 non-DED subjects and 70 DED patients were enrolled. Participants were examined for DED-related signs. Patients were also interviewed to ascertain the presence or absence of six common DED-related symptoms: dryness, irritation, pain, eye fatigue, blurring, and photophobia. Main outcome measures were differences in signs and symptoms of dry eye disease between boys and girls.RESULTS: Of the 323 adolescents recruited, 70(21.7%) were diagnosed with DED. Significant differences between the non-DED and DED groups were found for short tear break-up time(BUT; ≤5s; P=0.000) and superficial punctate keratopathy(SPK; staining score ≥3; P=0.000). Late adolescent girls reported fewer symptoms than late adolescent boys, although their DED-related signs were worse compared to other groups. The prevalence and severity of DED were similar in the Tokyo area compared with suburban and local areas but myopic errors were worse. CONCLUSION: We find that adolescents reported symptoms of DED similar to those found in adults, and the majority have short BUT-type DED. The prevalence and severity of DED in late adolescent girls is comparable with adults. Adolescents with DED are underserved and we believe that DED is a hidden but potentially serious health problem for this age group. | Masahiko Ayaki Motoko Kawashima Miki Uchino Kazuo Tsubota Kazuno Negishi | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 5 |
| 3 | Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography显示文摘AIM:To evaluate the relationship between liver stiffness and duration of infection in blood transfusion-associated hepatitis C virus (HCV) patients with or without hepatocellular carcinoma (HCC).METHODS:Between December 2006 and June 2008,a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were enrolled.Liver stiffness was obtained noninvasively by using Fibroscan (Echosens,Paris,France).The date of blood transfusion was obtained by interview.Duration of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement (LSM).Patients were stratified into four groups based on the duration of infection (17-29 years;30-39 years;40-49 years;and 50-70 years).The difference in liver stiffness between patients with and without HCC was assessed in each group.Multiple linear regression analysis was used to determine the factors associated with liver stiffness.RESULTS:A total of 524 patients underwent LSM.Eight patients were excluded because of unsuccessful measurements.Thus 516 patients were included in the current analysis (225 with HCC and 291 without).The patients were 244 men and 272 women,with a mean age of 67.8 ± 9.5 years.The median liver stiffness was 14.3 kPa (25.8 in HCC group and 7.6 in nonHCC group).The patients who developed HCC in short duration of infection were male dominant,having lower platelet count,with a history of heavier alcohol consumption,showing higher liver stiffness,and receiving blood transfusion at an old age.Liver stiffness was positively correlated with duration of infection in patients without HCC (r=0.132,P=0.024) but not in patients with HCC (r=-0.103,P=0.123).Liver stiffness was significantly higher in patients with HCC than in those without in each duration group (P < 0.0001).The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion (P < 0.0001),duration of infection (P=0.0015),and heavy alcohol consumption (P=0.043) CONCLUSION:Although liver stiffness gradually increases over time,HCC develops in patients with high stiffness value regardless of the duration of infection. | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino Kenichiro Enooku Eriko Goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi Goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike | 2012 | World Journal of Gastroenterology2012，18，12： | 4 |
| 4 | Rescue of white egg 1 mutant by introduction of the wildtype Bombyx kynurenine 3-monooxygenase gene显示文摘在蚕,白鸡蛋 1 (w-1 ) 异种,被白眼睛和白鸡蛋描绘,在 Bombyx kynurenine 3-monooxygenase (KMO ) 是缺乏的活动。Toinvestigate w-1 异种显型是否被介绍野类型的 KMO 基因救,我们在细胞质的肌动朊基因倡导者(A3KMO ) 或本国的 KMO 基因倡导者(KKMO ) 的控制下面与野类型的 Bombyx KMO 基因构造了转基因的蚕。我们与 KKMO 构造与 A3KMO 和一根线创造了二根转基因的线。在这些线的成年人的眼睛是棕色的,并且转基因的女性生的鸡蛋也是棕色的。Reversetranscription 聚合酶链反应(RT-PCR ) 分析证明 A3KMO 蚕线在中间勇气的、胖身体表示了抄本,并且肾小体小管。KKMO 线仅仅在胖身体表示了抄本并且肾小体小管。在转基因的线的眼睛和卵色的紧张与 KMO 表示水平成正比。有趣地,有 A3KMO 构造的转基因的幼虫有轻褐幼虫的表皮,而是 KKMO 线不。这些结果显示野类型的 KMO 基因能作为标记基因被使用视觉上屏蔽转基因的蚕。 | GUO-XING QUAN ISAO KOBAYASHI KATSURA KOJIMA KEIRO UCHINO TOSHIO KANDA HIDEKI SEZUTSU TORU SHIMADA TOSHIKI TAMURA | 2007 | Insect Science2007，14，2： | 4 |
| 5 | Phase transitions in the Pb(Zn1/3Nb2/3)O3-PbTiO3 system显示文摘 | KUWATA J UCHINO K NOMURA S | 1981 | Ferroelectrics1981，37，： | 3 |
| 6 | Early neurological deterioration represents recurrent attack in acute small non-lacunar stroke显示文摘 | Noriko Matsumoto Kazumi Kimura Chiaki Yokota Kiminobu Yonemura Kuniyasu Wada Makoto Uchino Kazuo Minematsu | 2003 | Journal of the Neurological Sciences2003，，2： | 3 |
| 7 | Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis显示文摘We experienced a very rare case of ulcerative colitis (UC) accompanied with analogous lesions in the stomach, duodenum, and ileal J -pouch. Ileal J-pouch anal anastomosis was performed on a 29-year old woman in 1996. Six years later, she was admitted again to our hospital because of epigastralgia, nausea, watery diarrhea and low fever. Based on the results of endoscopic examination, we diagnosed it as pouchitis. Moreover, on hypotonic duodenography, expansion of the duodenal bulb and the descending portion were poor. Kerckring folds disappeared with typical lead-pipe appearance. The pathogenesis of the gastric and duodenal lesion in this patient was similar to that of the colonic lesions of UC. For the gastroduodenal lesions in this patient, symptomatic remission was obtained following administration of crushed mesalazine tablets (1500 mg/d) for 14 d with continuous administration of omeprazole. Firstly we used ciprofloxacin to treat pouchitis. On the fifth day, she got a fever because of catheter infection. In the catheter culture, methicillin-resistant Staphylococcus aureus (MRSA) was detected. Therefore we changed ciprofloxacin to vancomycin hydrochloride (Vancomycin?). Vancomycin was very effective, and the stool frequency dramatically improved in three days. Now she continues to take mesalazine, but her condition is stable and there has been no recurrence of pouchitis. | Hiroki Ikeuchi Kazutoshi Hori Takashi Nishigami Hiroki Nakano Motoi Uchino Mitsuhiro Nakamura Nobuaki Kaibe Masafumi Noda Hidenori Yanagi Takehira Yamamura | 2006 | World Journal of Gastroenterology2006，12，36： | 3 |
| 8 | Long-term efficacy of infliximab maintenance therapy for perianal Crohn’s disease显示文摘AIM:To assess the long-term efficacy of seton drainage with infliximab maintenance therapy in treatment of stricture for perianal Crohn’s disease(CD). METHODS:Sixty-two patients with perianal CD who required surgical treatment with or without infliximab between September 2000 and April 2010 were identified from our clinic’s database.The activities of the perianal lesions were evaluated using the modified perianal CD activity index(mPDAI)score.The primary endpoint was a clinical response at 12-15 wk after surgery as a shortterm efficacy.Secondary endpoints were recurrence as reflected in the mPDAI score,defined as increased points in every major element.The clinical responses were classified as completely healed(mPDAI=0),partially improved(mPDAI score decreased more than 4 points),and failure or recurrence(mPDAI score increased or decreased less than 3 points). RESULTS:There were 43 males and 19 females,of whom 26 were consecutively treated with infliximab after surgery as maintenance therapy.Complete healing was not seen.Failure was seen in 10/36(27.8%) patients without infliximab and 4/26(15.4%)patients with infliximab(P=0.25).Partial improvement was seen in 26/36(72.2%)patients without infliximab and 22/26(88.5%)patients with infliximab(P=0.25). Short-term improvement was achieved in 48/62(77.4%) patients.Although the mPDAI score improved significantly with surgery regardless of infliximab,it decreased more from baseline in patients with infliximab(50.0%) than in those without infliximab(28.6%),(P=0.003). In the long-term,recurrence rates were low regardless of infliximab in patients without anorectal stricture.In patients with anorectal stricture,cumulative recurrence incidences increased gradually and exceeded 40%at 5 years regardless of infliximab.No efficacy of infliximab treatment was found(P=0.97).Although the cumulative rate of ostomy creation was also low in patients without stricture and high in patients with stricture,no protective efficacy was found with infliximab treatment(P =0.6 without stricture,P=0.22 with stricture). CONCLUSION:Infliximab treatment was demonstrated to have short-term efficacy for perianal lesions.Longterm benefit with infliximab was not proven,at least in patients with anorectal stricture. | Motoi Uchino Hiroki Ikeuchi Toshihiro Bando Hiroki Matsuoka Yoshio Takesue Yoshiko Takahashi Takayuki Matsumoto Naohiro Tomita | 2011 | World Journal of Gastroenterology2011，17，9： | 2 |
| 9 | Critical exponents of the dielectric constants in diffused-phase-transition crystals显示文摘 | Kenji Uchino Shoichiro Nomura | 1982 | Ferroelectrics1982，，1： | 2 |
| 10 | Clearance of vancomycin during high-volume heamofiltration: impact of pre-dilution 显示文摘 | Uchino S Cole L Morimatsu H | 2002 | Intensive Care Med2002，，28： | 2 |
| 11 | Longitudinal - Bending Mode Micromotor Using Multilayer Piezoelectric Actuator 显示文摘 | Kui Yao Burhanettin Koc Kenji Uchino | 2001 | IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL2001，48，4： | 2 |
| 12 | A piezoelectric motor using two orthogonal bending modes of a hollow cylinder显示文摘 | Koc B Cagatay S Uchino K | 2002 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2002，49，6： | 1 |
| 13 | Intake of arsenic from water, food composites and excretion through urine, hair from a studied population in West Bengal, India显示文摘 | Uchino T Roychowdhury T Ando M | 2006 | Food and Chemical Toxicology2006，44，： | 1 |
| 14 | 3 dimensional flow measurement at heading face and application of CFD 显示文摘 | NAKAYAMA S UCHINO K INOUE M | 1996 | Shigen-to-Sozai1996，112，9： | 1 |
| 15 | New Practical Method for Calculation of Air Temperature and Humidity Along Wet Roadway-The Influence of Moisture on The Underground Environment in Mines (2nd Report) 显示文摘 | Uchino K Inoue M | 1986 | Journal of the Mining and Metallurgical Institute of Japan1986，，6： | 1 |
| 16 | Transient detection of early wal- lerian degeneration on diffusion-weighted MRI after an acute cerebro- vascular accident显示文摘 | Uchino A Sawada A Takase Y | 2004 | Neuroradiology2004，46，3： | 1 |
| 17 | The relationship be- tween social support and physiological process: A review with em- phasis on underlying mechanisms and implications for health 显示文摘 | Uchino BN Cacioppo JT Kiecolt-Glaser JK | 1996 | Psychol Bull1996，119，3： | 1 |
| 18 | Differential effects of urinary and recombinant chorionic gonadotropin on oxida- tive stress responses in deeidualizing human endometrial stromal cells显示文摘 | KAJIHARA T TOCHIGI H UCHINO S | 2011 | Placenta2011，32，8： | 1 |
| 19 | Muscle biopsy findings predictive of malignancy in rare infiltrative dermatomyositis显示文摘 | Uchino M Yamashita S Uchino K | 2013 | Clin Neurol Neurosurg2013，115，5： | 1 |
| 20 | Acute renal failure in critically ill patients:a multinational,multicenter study显示文摘 | Uchino S Kellum JA Bellomo R | | 0，，： | 1 |
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