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| 1 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 6 |
| 2 | Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography显示文摘AIM:To evaluate the relationship between liver stiffness and duration of infection in blood transfusion-associated hepatitis C virus (HCV) patients with or without hepatocellular carcinoma (HCC).METHODS:Between December 2006 and June 2008,a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were enrolled.Liver stiffness was obtained noninvasively by using Fibroscan (Echosens,Paris,France).The date of blood transfusion was obtained by interview.Duration of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement (LSM).Patients were stratified into four groups based on the duration of infection (17-29 years;30-39 years;40-49 years;and 50-70 years).The difference in liver stiffness between patients with and without HCC was assessed in each group.Multiple linear regression analysis was used to determine the factors associated with liver stiffness.RESULTS:A total of 524 patients underwent LSM.Eight patients were excluded because of unsuccessful measurements.Thus 516 patients were included in the current analysis (225 with HCC and 291 without).The patients were 244 men and 272 women,with a mean age of 67.8 ± 9.5 years.The median liver stiffness was 14.3 kPa (25.8 in HCC group and 7.6 in nonHCC group).The patients who developed HCC in short duration of infection were male dominant,having lower platelet count,with a history of heavier alcohol consumption,showing higher liver stiffness,and receiving blood transfusion at an old age.Liver stiffness was positively correlated with duration of infection in patients without HCC (r=0.132,P=0.024) but not in patients with HCC (r=-0.103,P=0.123).Liver stiffness was significantly higher in patients with HCC than in those without in each duration group (P < 0.0001).The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion (P < 0.0001),duration of infection (P=0.0015),and heavy alcohol consumption (P=0.043) CONCLUSION:Although liver stiffness gradually increases over time,HCC develops in patients with high stiffness value regardless of the duration of infection. | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino Kenichiro Enooku Eriko Goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi Goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike | 2012 | World Journal of Gastroenterology2012，18，12： | 4 |
| 3 | Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma显示文摘 | Shunsuke Kondo Hidenori Ojima Hitoshi Tsuda Jun Hashimoto Chigusa Morizane Masafumi Ikeda Hideki Ueno Kenji Tamura Kazuaki Shimada Yae Kanai Takuji Okusaka | 2013 | International Journal of Clinical Oncology2013，，2： | 2 |
| 4 | Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells显示文摘AIM: To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning. METHODS: The in vitro effect of H2O2 pretreatment was investigated in rat isolated hepatocytes subjected to anoxia/reoxygenation. Cell viability was assessed with propidium iodide fluorometry. In other experiments, rat livers were excised and subjected to warm ischemia/ reperfusion in an isolated perfused liver system to determine leakage of liver enzymes. Preconditioning was performed by H2O2 perfusion, or by stopping the perfusion for 10 min followed by 10 min of reperfusion. To inhibit Kupffer cell function or reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, gadolinium chloride was injected prior to liver excision, or diphenyleneiodonium, an inhibitor of NADPH oxidase, was added to the perfusate, respectively. Histological detection of oxygen radical formation in Kupffer cells was performed by perfusion with nitro blue tetrazolium. RESULTS: Anoxia/reoxygenation decreased hepatocyte viability compared to the controls. Pretreatment with H2O2 did not improve such hepatocyte injury. In liver perfusion experiments, however, H2O2 preconditioning reduced warm ischemia/reperfusion injury, which wasreversed by inhibition of Kupffer cell function or NADPH oxidase. Histological examination revealed that H2O2 preconditioning induced oxygen radical formation in Kupffer cells. NADPH oxidase inhibition also reversed hepatoprotection by ischemic preconditioning. CONCLUSION: H2O2 preconditioning protects hepato- cytes against warm ischemia/reperfusion injury via NADPH oxidase in Kupffer cells, and not directly. NADPH oxidase also mediates hepatoprotection by ischemic preconditioning. | Kazuaki Tejima Masahiro Arai Hitoshi Ikeda Tomoaki Tomiya Mikio Yanase Yukiko Inoue Takako Nishikawa Naoko Watanabe Natsuko Ohtomo Masao Omata Kenji Fujiwara | 2007 | World Journal of Gastroenterology2007，13，38： | 2 |
| 5 | Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography显示文摘 | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Eriko Goto Takahisa Sato Takamasa Ohki Jun Imamura Tadashi Goto Fumihiko Kanai Naoya Kato Hitoshi Ikeda Shuichiro Shiina Takao Kawabe Masao Omata | 2009 | Hepatology2009，，： | 2 |
| 6 | The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations显示文摘The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are described.DMOODS was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary missions.The weighted least-squares batch filter is used for the orbit estimator of DMOODS.The orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small bodies.This system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking data.During the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the asteroid.One example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar corona.The large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of Hayabusa2.For the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by DMOODS.This type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before. | Hiroshi Takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota Kikuchi Hitoshi Ikeda Stefania Soldini Naoko Ogawa Yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani Manabu Yamada Toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 2 |
| 7 | A se- lective sac extraction method: another minimally invasive pro- cedure for inguinal hernia repair in children: a technical innova- tion with satisfactory surgical and cosmetic results显示文摘 | Hitoshi Ikeda Masahiro Hatanaka Makoto Suzuki | 2009 | Journal of pediatric surgery2009，4，8： | 1 |
| 8 | Correlation between Plasma Endotoxin, Plasma Cytokines, and Plasminogen Activator Inhibitor-1 Activities in Septic Patients显示文摘 | Tohru Tani Kazuyoshi Hanasawa Masashi Kodama Hitoshi Imaizumi Motoki Yonekawa Mikio Saito Toshiaki Ikeda Yoshihiro Yagi Kimihiro Takayama Izumi Amano Hideki Shimaoka Muneo Ohta Toshiya Okahisa Nobuhiko Koga Naohiro Fujita Haruhiko Yamasa | 2001 | World Journal of Surgery2001，，5： | 1 |
| 9 | Inflammatory pseudotumor of the liver: Case report and review of the literature显示文摘 | Masato Sakai Hitoshi Ikeda Norio Suzuki Atsushi Takahashi Minoru Kuroiwa Junko Hirato Shin-itsu Hatakeyama Yoshiaki Tsuchida | 2001 | Journal of Pediatric Surgery2001，，4： | 1 |
| 10 | Thrombocytopenia is more severe in patients with advanced chronic hepatitis C than B with the same grade of liver stiffness and splenomegaly显示文摘 | Kazuaki Tejima Ryota Masuzaki Hitoshi Ikeda Haruhiko Yoshida Ryosuke Tateishi Yosuke Sugioka Yukio Kume Tomoko Okano Tomomi Iwai Hiroaki Gotoh Sachiko Katoh Atsushi Suzuki Yukako Koike Yutaka Yatomi Masao Omata Kazuhiko Koike | 2010 | Journal of Gastroenterology2010，，8： | 1 |
| 11 | Expression of Osteopontin in Kupffer Cells and Hepatic Macrophages and Stellate Cells in Rat Liver after Carbon Tetrachloride Intoxication: A Possible Factor for Macrophage Migration into Hepatic Necrotic Areas显示文摘 | Rumiko Kawashima Satoshi Mochida Atsushi Matsui YuSuFu YouLuTuZ Keiko Ishikawa Keiko Toshima Fumio Yamanobe Mie Inao Hitoshi Ikeda Akihiko Ohno Sumiko Nagoshi Toshimitsu Uede Kenji Fujiwara | 1999 | Biochemical and Biophysical Research Communications1999，，3： | 1 |
| 12 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 13 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 14 | Considerations on surgical treatment for elderly patients with intracranial aneurysms显示文摘 | Qing Lan Hisato Ikeda Hiroyuki Jimbo Hitoshi Izumiyama Kiyoshi Matsumoto | 2000 | Surgical Neurology2000，，3： | 1 |
| 15 | Clinical outcomes of endoscopic submucosal dissection in elderly patients with early gastric cancer显示文摘 | Hajime Isomoto Ken Ohnita Naoyuki Yamaguchi Eiichiro Fukuda Kohki Ikeda Hitoshi Nishiyama Motohisa Akiyama Eisuke Ozawa Kazuhiko Nakao Shigeru Kohno Saburo Shikuwa | 2010 | European Journal of Gastroenterology & Hepatology2010，，3： | 1 |
| 16 | Infected duodenal duplication with unusual clinical and radiological manifestations: a case report显示文摘 | Kiyohiro Oshima Norio Suzuki Hitoshi Ikeda Atsushi Takahashi Minoru Kuroiwa Shigeru Ohki Shin-itsu Hatakeyama Yoshiaki Tsuchida Yasuo Morishita | 1998 | Pediatric Radiology1998，，7： | 1 |
| 17 | Evaluation of the safety and efficacy of esophagojejunostomy after totally laparoscopic total gastrectomy using a trans-orally inserted anvil: a single-center comparative study显示文摘 | Hiroaki Ito Haruhiro Inoue Noriko Odaka Hitoshi Satodate Manabu Onimaru Haruo Ikeda Daisuke Takayanagi Kenta Nakahara Shin-ei Kudo | 2014 | Surgical Endoscopy2014，，6： | 1 |
| 18 | FOXP1, an Estrogen-Inducible Transcription Factor, Modulates Cell Proliferation in Breast Cancer Cells and 5-Year Recurrence-Free Survival of Patients with Tamoxifen-Treated Breast Cancer显示文摘 | Takashi Shigekawa Nobuhiro Ijichi Kazuhiro Ikeda Kuniko Horie-Inoue Chikako Shimizu Shigehira Saji Kenjiro Aogi Hitoshi Tsuda Akihiko Osaki Toshiaki Saeki Satoshi Inoue | 2011 | Hormones and Cancer2011，，5： | 1 |
| 19 | The herbal medicine inchin-ko-to(TJ -135 )induces apoptosis in cultured rat hepatic stellate ceils显示文摘 | Hitoshi Ikeda Kayo Nagashima Mikio Yanase | 2006 | Life Sciences2006，78，： | 1 |
| 20 | Serum Autotaxin is not a Useful Biomarker for Ovarian Cancer显示文摘 | Kazuhiro Nakamura Koji Igarashi Ryunosuke Ohkawa Hiromitsu Yokota Akiko Masuda Shunsuke Nakagawa Tetsu Yano Hitoshi Ikeda Junken Aoki Yutaka Yatomi | 2012 | Lipids2012，，9： | 1 |
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