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| 1 | Human β-defensin-3 induction in H pylori-infected gastric mucosal tissues显示文摘AIM: To examine human β-defensin-3 (hBD-3) expression in inflamed gastric mucosal tissues or MKN45 gastric cancer cells with or without H pylori infection for better understanding the innate immune response to H pylori. METHODS: We used reverse transcription-polymerase chain reactions and immunohistochemistry to examine hBD-3 expression in inflamed gastric mucosal tissues or MKN45 gastric cancer cells with or without H pylori. Effects of hBD-3 against H pylori were also evaluated. RESULTS: The mean mRNA expression of hBD-3 in H pylori -positive specimens was significantly higher than that in H pylori-negative specimens (P = 0.0002, Mann-Whitney). In addition, unlike uninfected samples, 8 of 15 (53.33%) infected mucosal samples expressed hBD-3 protein. H pylori dose-dependently induced mRNA expression of hBD-3 in MKN45 cells, an effect inhibited by adding anti-toll-like receptor (TLR)-4 antibody. HBD-3 protein completely inhibited H pylori growth. CONCLUSION: Our results suggest that like hBD-2, hBD-3 may be involved in the pathophysiology of H pylori-induced gastritis. | K Kawauchi A Yagihashi N Tsuji N Uehara D Furuya D Kobayashi N Watanabe | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 2 | An titumor action of some basidiomycetes, especially Phellinus linteus显示文摘 | Ikekawa T Nakanishi M Uehara N | 1968 | Gann1968，59，： | 1 |
| 3 | Increased expression of CD44v6 mRNA significantly correlates with distant metastasis and poor prognosis in gastric cancer显示文摘 | Yammichi K Uehara Y Kitamura N | 1998 | Int J Cancer(Pred Oncol)1998，79，： | 1 |
| 4 | The CHA2DS2-VASc score predicts 320-slice CT-based coronary artery plaques and > 50% stenosis in subjects with chronic and paroxysmal atrial fibrillation显示文摘 | Funabashi N Uehara M Takaoka H | 2014 | Int J Cardio12014，172，1： | 1 |
| 5 | Enzymatic synthesis of 5-methyluridine from adenosine and thymine with hight efficiensy显示文摘 | Hori N Uehara K Mikami Y | 1992 | Biosci Biotech Biochem1992，56，4： | 1 |
| 6 | Increased expression of CD44v6 mRNA significantly correlates with distant metastasis and poor prognosis in gastric cancer显示文摘 | Yamamichi K Uehara Y Kitamura N | 1998 | Int J Cancer1998，79，： | 1 |
| 7 | Antitumor action of some basidiomycetes, especially Phellinus linteus 显示文摘 | Ikekawa T Nakanishi M Uehara N | 1968 | Gan1968，59，2： | 1 |
| 8 | Antitumor activity of aqueous extracts of edible mushrooms显示文摘 | Ikekawa T Uehara N Maeda Y | 1969 | Cancer Res1969，29，： | 1 |
| 9 | Hydriding properties of LaNi3and CoNi and their substitutes with PuNi3-type structure 显示文摘 | CHEN J TAKESHITA H T TANAKA H KURIYAMA N SAKAI T UEHARA I HARUTA M | 2000 | Journal of Alloys and Compounds2000，302，12： | 1 |
| 10 | Anitumor action of some basidiomycetes, especially Pbellinus linteus 显示文摘 | Ikekawa T Nakanishi M Uehara N | 1968 | Gann1968，59，9： | 1 |
| 11 | Synthesis of titania-doped mesoporous silica and its gas adsorbability显示文摘 | LI Xingyang UEHARA M ENOMOTO N | 2001 | J Ceram Soc Jpn2001，109，10： | 1 |
| 12 | Effects of different dura- tions of estrogen and progesterone treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats显示文摘 | Yuri T Tsukamoto R Uehara N | 2006 | In Vivo2006，20，6： | 1 |
| 13 | Study on solid-state chemistry of the ZnO/F%O4/H20 system for H2 production at 973-1 073 K显示文摘 | TAMAURA Y UEHARA R HASEGAWA N | 2004 | Solid State lonics2004，172，： | 1 |
| 14 | Analysis on distribution and genomic diversity of high-level antiseptic resistance gene qacA and qacB in human clinical isolates of Staphylococcus aureus显示文摘 | Alam MM Kobayashi N Uehara N | 2003 | Microb Drug Resist2003，9，2： | 1 |
| 15 | Echo Doppler velocimeter in the diagnosis of hypertensive patients:the renal artery Doppler technique显示文摘 | Fukunaga R Uehara A | 1986 | Ultrasound Med Biol1986，12，： | 1 |
| 16 | Vorinostat enhances protein stability of p27 and p21 through negative regula- tion of Skp2 and Cksl in human breast cancer eells显示文摘 | Uehara N Yoshizawa K Tsubura A | 2012 | Oneol Rep2012，28，1： | 1 |
| 17 | Antitumor action of some basidiomycetes,especially Phellinus/inteus显示文摘 | Iikekawa T Nakanishi M Uehara N | 1968 | Gann (Japanese Journal of Cancer Research)1968，59，9： | 1 |
| 18 | Abnormal collateral arterial systems in Takayasu's arteritis and Lerieche's syndrome evaluated by whole body acquisition using multislice computed tomography 显示文摘 | Ando H Funabashi N Uehara M et at | 2007 | Int J Cardiol2007，121，： | 1 |
| 19 | Endogenous reactive oxygen species is an important mediator of miconazole antifungal effect显示文摘 | Kobayashi D Kondo K Uehara N Otokozawa S Tsuji N Yagihashi A | 2002 | Antimieb Agents Chemother2002，46，： | 1 |
| 20 | Epalrestat,an aldose reductase inhibitor,improves an impaired generation of oxygen-derived flee radicals by neutrophils from poorly controlled NIDDM patients显示文摘 | SATO N KASHIMA K UEHARA Y etal | 1997 | Diabetes Care1997，20，6： | 1 |
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