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8篇 您的检索式:作者名="UGIDOS A"
    题名 作者 年代 出处 被引量
1Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments显示文摘The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic insult.The use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects.In this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic inflammation.This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area.We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia.Moreover,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal sprouting.However,this treatment decreased the formation of neuronal progenitor cells.This study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies.Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez JoséManuel Gonzalo-Orden Arsenio Fernández-López 2023Neural Regeneration Research2023,18,9:3
2Food ingredients as antiobesity agents:a review显示文摘Trigueros L Pena S Ugidos A V 2013Crit Rev Food Sci Nutr2013,53,9:1
3Food ingredients as antiobesity agents:a review显示文摘Trigueros L Pena S Ugidos A V 2013Critical reviews in food science and nutrition2013,53,9:1
4More on Identification in Detailed Wage Decomposition 显示文摘Gardeazabal J Ugidos A 2004Review of Economics and Statistics2004,86,4:1
5Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing显示文摘Caballero A Ugidos A Liu B 2011Mol Cell2011,42,3:1
6Perspectives on the mitochondrial etiology of replicative aging in yeast显示文摘Ugidos A Nystrom T Caballero A 2010Experimental Gerontology2010,78,45:1
7Gender wage discrimination at quantiles 显示文摘GARDEAZABAL J UGIDOS A 2005Journal of population economics2005,18,1:1
8Middle Ear Carcinoma显示文摘Martinez Subias J Dominguez Ugidos LJ Urpegui Garcia A 1998Acta Otorrinolaringol Esp1998,49,3:1
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