|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Presentation,management,and outcome of newly diagnosed glioblastoma in elderly patients显示文摘OBJECT: Optimum management for elderly patients with newly diagnosed glioblastoma(GBM) in the temozolomide(TMZ) era is not well defined.The object of this study was to clarify outcomes in this population.METHODS: The authors retrospectively reviewed 105 consecutive cases involving elderly patients(age ≥ 65 years) with newly diagnosed GBM who were treated at the Mayo Clinic between 2003 and 2008.RESULTS: The patients' median age was 74 years(range 66-87 years),and the median Karnofsky Performance Status(KPS) score was 80(range 40-90).Half of the patients underwent biopsy and half underwent resection.Patients with deep-seated lesions(19 patients [18%]) or multifocal lesions(34 patients [32%]) were more likely to have biopsy than resection(p = 0.0001 and 0.0009,respectively).New persistent neurological deficits developed in 7 patients(6.7%).Postoperative hemorrhage occurred in 6 patients(5.7%),all of whom underwent biopsy.Complete follow-up data regarding adjuvant treatment was available in 84 patients.Forty-one(49%) were treated with chemotherapy(mostly TMZ) and radiation therapy(RT),and 23(27%) with RT alone.Nineteen(23%) received only palliative care after surgery(more common with biopsy,p = 0.03).Chemotherapy complications occurred in 28.6%(Grade 3 or 4 hematological complications in 11.9%).The median values for progression-free survival(PFS) and overall survival(OS) were 3.5 and 5.5 months.In a multivariate analysis,younger age(p = 0.03,risk ratio [RR] 0.34,95% CI 0.13-0.89),single lesion(p = 0.02,RR 0.51,95% CI 0.30-0.89),resection(p = 0.04,RR 0.54,95% CI 0.31-0.94),and adjuvant treatment(p = 0.0001,RR 0.24,95% CI 0.11-0.49) were associated with better OS.Only adjuvant treatment was significantly associated with prolonged PFS(p = 0.0007,RR 0.27,95% CI 0.13-0.57).With combined therapy with resection,RT,and chemotherapy,the median PFS and OS were 8 and 12.5 months,respectively.CONCLUSIONS: The prognosis for GBM worsens with increasing age in elderly patients.With important risks,resection and adjuvant treatment are associated with prolonged survival.Although selection bias cannot be excluded in this retrospective study,advanced age alone should not necessarily preclude optimal resection followed by adjuvant radiochemotherapy. | Tanaka S Meyer FB Buckner JC Uhm JH Yan ES Parney IF | 2013 | 中国神经肿瘤杂志2013，11，1： | 4 |
| 2 | Clinical outcomes of metastatic breast cancer patients with triple-negative phenotype who received platinumcontaining chemotherapy显示文摘 | Yi S Uhm J Cho E | 2008 | J Clin Oncol2008，26，15： | 1 |
| 3 | TeOz nanoparticles synthe sized by evaporation of tellurium in atmospheric microwaveplasma torchflame 显示文摘 | Cho S C Hong Y C Uhm H S | 2006 | Chem Phys Lett2006，429，： | 1 |
| 4 | Clinical outcomes of metastatic breast can-cer p8tients with triple-negative phenol type who received platinumcontaining chemotherapy显示文摘 | Yi S Uhm J Cho E | 2008 | J ClinOneol2008，26，： | 1 |
| 5 | Analytical investiga tion of electrical breakdown properties in a nitrogen-SF6 mix turegas显示文摘 | Uhm H S Byeon Y S Song K B | 2010 | Physics of Plasmas2010，17，11： | 1 |
| 6 | Intergranular Corrosion of Ti-Stabilized 11 wt% Cr Ferritic Stainless Steel for Automotive Exhaust Systems 显示文摘 | Kim J K Kim Y H Uhm S H | 2009 | Corrosion Science2009，51，11： | 1 |
| 7 | Production of Nanocrystalline Y2Oa : Eu Powder by Microwave Plasma-Torch and Its Characterization 显示文摘 | Cho S C Uhm H S Bang C U | 2009 | Thin Solid Films2009，517，： | 1 |
| 8 | Breakdown temperature of electrons in SF6 gas显示文摘 | Uhm H S Choi E H Cho G etal | 2010 | Applied Physics Letters2010，97，16： | 1 |
| 9 | A Dual-Passband Filter ofCanonical Structure for Satellite Application显示文摘 | Lee J Uhm M S Yom I B | 2004 | IEEEMicrowave and Wireless Components Letters2004，14，6： | 1 |
| 10 | 显示文摘 | Kim W C Kim S J Uhm Y R | 2001 | IEEE Trans Magn2001，37，4： | 1 |
| 11 | Purification and characterization of Aspergillus ficuum endoinulinase显示文摘 | Uhm T B Chung M S Lee S H | 1999 | Bioscience Biotechnology and Biochemistry1999，63，1： | 1 |
| 12 | A theory of cavity excitation by modulated electron beam in connection with application to a klys- tron amplifier显示文摘 | Uhm H S Park G S Armslrong C M | 1993 | Physicsol Fluids B Plasma Physics1993，5，： | 1 |
| 13 | Purification and characterization of Aspergillus ficuum Endoinulinasde显示文摘 | UHM TAI-BOONG CHUNG M S | 1999 | Biosci Biotechnol Biochem1999，63，1： | 1 |
| 14 | Cytokine balance in kidney tissue from lupus nephritis patients显示文摘 | Uhm W S Na K Song G W | 2003 | Rheumatology2003，42，8： | 1 |
| 15 | A survey of the Brassica rapa genome by BAC-end sequence analysis and comparison with Arabidopsis thaliana显示文摘 | Hong C P Plaha P Koo D H Yang T J Choi S R Lee Y K Uhm T Bang J W Edwards D Bancroft Ⅰ Park B S Lee J Lim Y P | | 0，，： | 1 |
| 16 | Diocotron instability for intense relativistic non-neutral electron flow in planar diode geometry显示文摘 | Davidson R C Tsang K T Uhm H S | 1988 | Phys Fluids1988，31，6： | 1 |
| 17 | Activity of Pt anode catalyst modified by underpotential deposited Pb in a direct formic acid fuel cell显示文摘 | UHM S CHUNG S T LEE J | 2007 | J Electrochem Commun2007，9，8： | 1 |
| 18 | Diocotron instability of a relativistic sheet electron beam propagating through a rectangular conducting wall显示文摘 | Uhm H S Shahar Ben-Menahem S Yu D | 1994 | Phys Plasmas1994，1，11： | 1 |
| 19 | Analytical investigation of electrical breakdown properties in a nitrogen-SF6 mixture gas显示文摘 | Uhm H S Byeon Y S Song K B | 2010 | Physics of Plasmas2010，17，11： | 1 |
| 20 | Acetylcholine receptor ag-gregation at nerve-muscle contacts in mammalian cul-tures:induction by ventral spinal cord neurons is specif-ic to axons显示文摘 | Dutton E K Uhm C S Samuelsson S J Schaffner A E Fitzgerald S C Daniels M P | 1995 | J Neurosci1995，15，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员