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| 1 | Translational pain research: Evaluating analgesic effect in experimental visceral pain models显示文摘Deep visceral pain is frequent and presents major challenges in pain management, since its pathophysiology is still poorly understood. One way to optimize treatment of visceral pain is to improve knowledge of the mechanisms behind the pain and the mode of action of analgesic substances. This can be achieved through stand-ardized experimental human pain models. Experimental pain models in healthy volunteers are advantageous for evaluation of analgesic action, as this is often diff icult to assess in the clinic because of confounding factors such as sedation, nausea and general malaise. These pain models facilitate minimizing the gap between knowledge gained in animal and human clinical studies. Combining experimental pain studies and pharmacokinetic stud- ies can improve understanding of the pharmacokinetic-pharmacodynamic relationship of analgesics and, thus, provide valuable insight into optimal clinical treatment of visceral pain. To improve treatment of visceral pain, it is important to study the underlying mechanisms of pain and the action of analgesics used for its treatment. An experimental pain model activates different modalities and can be used to investigate the mechanism of action of different analgesics in detail. In combination with pharmacokinetic studies and objective assessment such as electroencephalography, new information re-garding a given drug substance and its effects can be obtained. Results from experimental human visceral pain research can bridge the gap in knowledge between animal studies and clinical condition in patients suffering from visceral pain, and thus constitute the missing link in translational pain research. | Anne Estrup Olesen Trine Andresen Lona Louring Christrup Richard N Upton | 2009 | World Journal of Gastroenterology2009，15，2： | 3 |
| 2 | Effect of estab - lished and putative anxiolytics on extracellular 5 - HT and 5 - HIAA in the ventral hippocampus of rats during behavior on the elevated X - maze显示文摘 | Wright IK Upton N Marsden CA | 1992 | Psy - chop harmacology1992，109，3： | 1 |
| 3 | Differential adrenomedullin rel ease and edothelin receptor expression in distinct subpopulations of human airway smooth-muscle cells显示文摘 | Upton PD Wharton J Davie N | 2001 | Am J Respir Cell Mol Bi- o12001，25，3： | 1 |
| 4 | Organ weights and blood flows of sheep and pig for physiological pharmacokinetic modelling显示文摘 | Upton R N | 2008 | J Pharmacol Toxicol Methods2008，58，3： | 1 |
| 5 | A physiologically based,recirculatory model of the kinetics and dynamics of propofol in man显示文摘 | UPTON R N LUDBROOK G | 2005 | Anesthesiology2005，103，2： | 1 |
| 6 | A drenomedullin expression and growth inhibitory effects in distinct pulmonary artery smooth muscle cell subpopulations显示文摘 | Upton PD Wharton J Coppock H Davie N Yang X Yacoub MH Ghatei MA Polak JM Bloom SR Smith DM Morrell NW | 2001 | Am J Respir Cell Mol Biol2001，24，2： | 1 |
| 7 | Cardiac output is a determinant of the initial concentrations of propofol after shortinfusion administration显示文摘 | UPTON R N LUDBROOK G L GRANT C | 1999 | Anesth Analg1999，89，3： | 1 |
| 8 | The use of mass balance principles to describe regional drug distribution and elimination 显示文摘 | Upton R N Mather L E Runciman W B | 1988 | J Pharmacokinet Biopharm1988，16，1： | 1 |
| 9 | The novel brain heuropeptide,orex-in-A,modulates the sleep-wake cycleofrats显示文摘 | Piper DC Upton N | 2000 | Eur J Neurosci2000，12，： | 1 |
| 10 | Prolonged disequilibrium between blood and brain concentrations of propofol during infusions in sheep 显示文摘 | Lubrook G L Upton R N Martinez G A | 1999 | Acta Anaesthesiol Scand1999，43，2： | 1 |
| 11 | A model of the kinetics and dynamics of induction of anaesthesia in sheep:variable estimation for thiopental and comparison with propofol显示文摘 | UPTON R N LUDBROOK G L | 1999 | Br J Anaesth1999，82，6： | 1 |
| 12 | The evolution of video surveillance : an overview 显示文摘 | HAERING L V N PETER A UPTON A | 2008 | Machine Vision and Applications2008，19，： | 1 |
| 13 | Arylamine N-acetyltransferases-of mice,men and microorganisms显示文摘 | Upton A Johnson N Sandy J | 2001 | Trends Pharmacol Sci2001，22，3： | 1 |
| 14 | 5 -HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease 显示文摘 | Upton N Chuang TT Hunter AJ | 2008 | Neurotherapeutics2008，5，3： | 1 |
| 15 | ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells显示文摘 | Davie N Haleen SJ Upton PD | 2002 | Am J Respir Crit Care Med2002，165，3： | 1 |
| 16 | ET (B) receptors modulate the proliferation of human pulmonary artery smoonth muscle cells显示文摘 | Davie N Holeen S J Upton PD | 2002 | Am J Respire Cirt Care Med2002，15，2： | 1 |
| 17 | Strategic and business planning practices of fast growth family firms 显示文摘 | UPTON N TEAL E J FELAN J T | 2001 | Journal of Small Business Management2001，39，1： | 1 |
| 18 | ETA and ETB receptors mod- ulate the prolifera-tion of human pulmonary artery smooth muscle cells显示文摘 | Davie N Haleen S J Upton PD | 2002 | Respir Crit Care Med2002，165，3： | 1 |
| 19 | ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells 显示文摘 | Davie N Haleen SJ Upton PD Polak JM Yacoub MH Morrell NW | 2002 | Am J Respir Crit Care Med2002，165，： | 1 |
| 20 | Venture Capital Investment and US Family Business显示文摘 | UPTON N PETTY W | | 0，，： | 1 |
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