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| 1 | Aerobic bacteria associated with chronic suppurative otitis media in Angola显示文摘Background:Chronic suppurative otitis media(CSOM)is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions.Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas.The goal of this study was to define aerobic pathogens associated with CSOM in Angola with the overall aim to provide a background for local treatment recommendations.Methods:Samples from ear discharge and the nasopharynx were collected and cultured from 152 patients with ear discharge and perforation of the tympanic membrane.Identification of bacterial species was performed with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and pneumococci were serotyped using multiplex polymerase chain reactions.Antimicrobial susceptibility testing was done according to EUCAST.Results:One hundred eighty-four samples from ear discharge and 151 nasopharyngeal swabs were collected and yielded 534 and 289 individual isolates,respectively.In all patients,correspondence rate of isolates from 2 ears in patients with bilateral disease was 27.3%and 9.3%comparing isolates from the nasopharynx and ear discharge,respectively.Proteus spp.(14.7%),Pseudomonas aeruginosa(13.2%)and Enterococcus spp.(8.8%)were dominating pathogens isolated from ear discharge.A large part of the remaining species belonged to Enterobacteriaceae(23.5%).Pneumococci and Staphylococcus aureus were detected in approximately 10%of nasopharyngeal samples.Resistance rates to quinolones exceeded 10%among Enterobacteriaceae and was 30.8%in S.aureus,whereas 6.3%of P.aeruginosa were resistant.Conclusions:The infection of the middle ear in CSOM is highly polymicrobial,and isolates found in nasopharynx do not correspond well with those found in ear discharge.Pathogens associated with CSOM in Angola are dominated by gram-negatives including Enterobacteriaceae and P.aeruginosa,while gram-positive enterococci also are common.Based on the results of antimicrobial susceptibility testing topical quinolones would be the preferred antibiotic therapy of CSOM in Angola.Topical antiseptics such as aluminium acetate,acetic acid or boric acid,however,may be more feasible options due to a possibly emerging antimicrobial resistance. | Fabian Udden Matuba Filipe Ake Reimer Maria Paul Erika Matuschek John Thegerstrom Sven Hammerschmidt Tuula Pelkonen Kristian Riesbeck | 2018 | Infectious Diseases of Poverty2018，7，1： | 6 |
| 2 | Effects of glucocorticoids on leptin levels and eating behaviour in women显示文摘 | Udden J Bjorntorp P Arner P | 2003 | J Intern Med2003，253，2： | 1 |
| 3 | Mechanical composition of clastic sediments显示文摘 | Udden J A | 1914 | Bulletin of the Geological Society of America1914，，25： | 1 |
| 4 | Mechanical composition of clastic sediments显示文摘 | Udden J A | 1914 | GSA Bul- letin1914，25，： | 1 |
| 5 | Butoxyacetic acid-induced hemolysis of rat red blood cells: effect of external osmolarity and cations 显示文摘 | Udden MM Patton CS | 2005 | Toxicol Lett2005，156，1： | 1 |
| 6 | Control of red blood cell mass in spaceflight 显示文摘 | Alfrey C P Udden M M Leach-Huntoon C | 1996 | J Appl Physiol1996，81，1： | 1 |
| 7 | Mechanical composition of clastic sediments显示文摘 | UDDEN J A | 1914 | Bulletin of the Geological Society of America1914，25，： | 1 |
| 8 | c-ABL tyrosine kinase modulates p53-dependent p21 induction and ensuing cell fate decision in response to DNA damage 显示文摘 | Udden S M Morita-Fujimura Y Satake M | 2014 | Cell Signal2014，26，2： | 1 |
| 9 | Quorum-regulated biofilms enhance the development of conditionally viable,environmental Vibrio cholerae显示文摘 | Kamruzzaman M Udden SM Cameron DE | 2010 | Proc Natl Acad Sci USA2010，107，4： | 1 |
| 10 | Mechanical composition of some clastic sediments显示文摘 | J Udden | 1914 | Bulletin of the Geological Society of America1914，25，： | 1 |
| 11 | Downregulation of uncoupling protein 2 mRNA in women treated with glucocorticoids显示文摘 | Udden J Folkesson R Hoffstedt J | 2001 | Int J Obes Relat Metab Disord2001，25，11： | 1 |
| 12 | In vitro sub-hemolytic effects of butoxyacetic acid on human and rat erythrocytes显示文摘 | Udden MM | | 0，，01： | 1 |
| 13 | Flow cytometric studies of platelet responses to shear stress in whole blood显示文摘 | Konstantopoulos K Wu K K Udden M M | 1995 | Biorheology1995，32，1： | 1 |
| 14 | Neocytolysis:physiological down-regulator of red-cell mass显示文摘 | Alfrey CP Rice L Udden MM | 1997 | Lancet1997，349，9062： | 1 |
| 15 | Control of red blood cell mass in spaceflight显示文摘 | Alfrey CR Udden MM Leach-Huntoon C | 1996 | J Appl Physiol1996，81，1： | 1 |
| 16 | Donor cells leukemia: Report of a case occurring 11 years after Allogeneic bone marrow transplantation and review of the literature显示文摘 | COOLEY L D SEARS D A UDDEN M M | 2000 | Am J of Hematology2000，63，： | 1 |
| 17 | Dust and sand storms in the west显示文摘 | Udden J A | | Popular Sci- ence Monthly0，49，： | 1 |
| 18 | Effect of phage on the infectivity of Vibrio cholerae and emer- gence of genetic variants显示文摘 | Zahid M S Udden S M Faruque A S | 2008 | Infect Immun2008，76，11： | 1 |
| 19 | Transmissibility of cholera:in vivo-formedbiofilms and their relationship to infectivity and persistence in the environment显示文摘 | Biswas K Udden SM | 2006 | Proc Natl Acad Sci USA2006，103，16： | 1 |
| 20 | Effects of glucocorticoids on leptin levels and eating behaviour in women显示文摘 | Udden J Bjorntorp P Arner P | 2003 | Interm Med2003，253，2： | 1 |
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