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| 1 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 2 | Bone marrow transplant cure for beta-thalassaemia major:, initial experience from a developing country显示文摘 | Ullah K Khan B Raza S | 2008 | Ann Hematol2008，87，： | 1 |
| 3 | Advances in phytase research 显示文摘 | Mullaney E J Daly C B Ullah A H | 2000 | Advances in Applied Microbiology2000，，47： | 1 |
| 4 | Advances in phytaseresearch显示文摘 | MULLANEY E J DALY C B ULLAH A H | 2000 | Adv Appl Microbiol2000，47，： | 1 |
| 5 | Advances in phytase research显示文摘 | Mullaney E J Daly C B Ullah A H | 2000 | Adv Appl Microbiol2000，47，： | 1 |
| 6 | The β- subunit of the Arabidopsis G protein negatively regulates auxininduced cell division and affects multiple developmental processes显示文摘 | Ullah H Chen J G Temple B | 2003 | Plant Cell2003，15，： | 1 |
| 7 | Deflection coefficient maximization criterion based optimal cooperative spectrum sensing显示文摘 | Shen B Ullah S Kwak K | 2010 | AEU -International Journal of Electronics and Communications2010，64，9： | 1 |
| 8 | Advances in phytase research 显示文摘 | Mullaney E J Daly C B Ullah A H | 2000 | Advances in Applied Microbiology2000，47，： | 1 |
| 9 | Forecasts of COPD mortality in Australia: 2006-2025显示文摘 | Erbas B Ullah S Hyndman RJ | 2012 | BMC Med Res Methodol2012，12，： | 1 |
| 10 | Classification, prucessing ad application of hydrogels: A review 显示文摘 | Ullah F Othman M B H Javed F Ahmad Z Akil H M | 2015 | Materials Science and Engineering: C2015，57，1： | 1 |
| 11 | Performance comparison among some nonlinear filters for a low cost SINS/GPS inte- grated solution 显示文摘 | Ali J Ullah B M M | 2010 | Nonlinear Dynamics2010，61，3： | 1 |
| 12 | Cardiac organ donor management显示文摘 | Ullah S Zabala L Watkins B | 2006 | Perfusion2006，21，2： | 1 |
| 13 | Weight and plasma lipid control by decaffeinated green tea显示文摘 | DORIANE R KAOUTHAR K ULLAH B | 2009 | Pharmacological Research2009，59，： | 1 |
| 14 | The betasubunit of the Arabidopsis G protein negatively regulates auxin-induced cell division and affects multiple developmental processes显示文摘 | Ullah H Chen J G Temple B | 2003 | Plant Cell2003，15，： | 1 |
| 15 | The {beta}-subunit of the Arabidopsis G protein negatively regulates auxin-induced cell division and affects multiple developmental processes显示文摘 | Ullah H Chen J G Temple B | 2003 | Plant Cell2003，15，2： | 1 |
| 16 | Sero-epidemiology of peste des petitsruminants (PPR)in Pakistan显示文摘 | Zahur A B Ullah A Hussain M | 2011 | Preventive Veterinary Medicine2011，102，1： | 1 |
| 17 | Advances in phytase research 显示文摘 | Mullaney E J Daly C B Ullah A H | 2000 | Advances in Applied Microbiology2000，，47： | 1 |
| 18 | Three-dimensional nonlinear finite-ele- ment analysis of gasketed flange joint under combined in- ternal pressure and variable temperatures显示文摘 | Abid M Ullah B | 2007 | Journal of Engineering Mechanics2007，133，2： | 1 |
| 19 | Advances in phytase research显示文摘 | Mullaney E J Daly C B Ullah A H | 2000 | Adv Appl Microbiol2000，，47： | 1 |
| 20 | A comprehensive survey of wireless body area networks on PHY,MAC,and network layers solutions显示文摘 | ULLAH S HIGGINS H BRAEM B | | 0，，03： | 1 |
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