|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: Detection by oligonucleotide microarray and real-time PCR analysis显示文摘AIM: To investigate the molecular pathways involved in human cholangiocarcinogenesis by gene expression profiling. METHODS: Oligonucleotide arrays (Affymetrix U133A) were used to establish a specific gene expression profile of intrahepatic CCC in comparison to corresponding non- malignant liver tissue. To validate the expression values of the most overexpressed genes, RT-PCR experiments were performed. RESULTS: Five hundred and fifty-two statistically differentially expressed genes/ESTs (221 probes significantly up-regulated, 331 probes down-regulated; P < 0.05; fold change > 2; ≥ 70%) were identified. Using these data and two-dimensional cluster analysis,a specific gene expression profile was obtained allowing fast and reproducible differentiation of CCC, which was confirmed by supervised neuronal network modelling. The most consistently overexpressed gene (median fold change 33.5, significantly overexpressed in 100%) encoded osteopontin. Furthermore, an association of various genes with the histopathological grading could be demonstrated. CONCLUSION: A highly specific gene expression profile for intrahepatic CCC was identified, allowing for its fast and reproducible discrimination against non- malignant liver tissue and other liver masses. The most overexpressed gene in intrahepatic CCC was the gene encoding osteopontin. These data may lead to a better understanding of human cholangiocarcinogenesis. | Holger G Hass Oliver Nehls Juergen Jobst Andrea Frilling Ulrich Vogel Stephan Kaiser | 2008 | World Journal of Gastroenterology2008，14，16： | 4 |
| 2 | 灭菌及中央供应室管理的欧洲及国际标准显示文摘1 灭菌相关标准概述
涉及到灭菌方面的国际标准很多,主要包括灭菌过程的确认、常规监测、化学和生物指示物以及它们的使用指南、医疗产品生产及管理体系方面。欧盟的医疗设备指令(MDD)93/42/EEC是于1993年6月14日欧盟理事会在卢森堡确定的,1995年1月1日开始在欧盟25个成员国内生效,但是有一个转换期,从1998年6月15日起在所有欧盟成员国内强制执行。 | Ulrich Kaiser 钱英杰(译) | 2008 | 中国护理管理2008，8，2： | 4 |
| 3 | Do media consumers really dislike advertising? An empirical assessment of the role of advertising in print media markets显示文摘 | Ulrich Kaiser Minjae Song | 2008 | International Journal of Industrial Organization2008，，2： | 3 |
| 4 | 带冷却段的中密度纤维板连续压机显示文摘 | Marius Barbu Dieter Hoepner Karl Lerach Helmut Roll Peter Beck Ulrich Kaiser | 2002 | 林产工业2002，29，2： | 3 |
| 5 | Price structure in twosided markets,evidence from the magazine industry显示文摘 | Ulrich Kaiser | 2006 | International Journal of Industrial Organization2006，24，1： | 1 |
| 6 | Price Structure in Two sided Markets: Evidence from the Magazine Industry 显示文摘 | Jullien Wright Ulrich Kaiser | 2006 | International Journal of Industrial Organization2006，，24： | 1 |
| 7 | Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C显示文摘 | Martin Lechmann Rainer P Woitas Bettina Langhans Rolf Kaiser Hans Georg Ihlenfeldt Günther Jung Tilman Sauerbruch Ulrich Spengler | 1999 | Journal of Hepatology1999，，6： | 1 |
| 8 | A low-power transponder IC for high-performance identification systems 显示文摘 | Ulrich Kaiser Wolfgang Steinhagen | 1995 | IEEE Joural of Solid-state Circuits1995，30，3： | 1 |
| 9 | Measuring knowledge spillovers in manufacturing and services: an empirical assessment of alternative approaches显示文摘 | Ulrich Kaiser | 2002 | Research Policy2002，31，1： | 1 |
| 10 | Early diagnosis of cerebral involvement in Sturge-Weber syndrome using high-resolution BOLD MR venography显示文摘 | Hans-J. Mentzel Andrea Dieckmann Clemens Fitzek Ulrich Brandl Jürgen R. Reichenbach Werner A. Kaiser | 2005 | Pediatric Radiology2005，，1： | 1 |
| 11 | Price structure in two-sided markets: Evidence from the magazine industry显示文摘 | ULRICH KAISER JULIAN WRIGHT | 2006 | InternationalJournal of Industrial Organization2006，24，1： | 1 |
| 12 | Pushing deep ultraviolet lithography to its limits显示文摘 | Totzeck M Ulrich W Gohnermeier A Kaiser W | 2007 | Nature Photonics2007，1，： | 1 |
| 13 | Balancing Internal and External Knowledge Acquisition: The Gains and Pains from R&D Outsourcing显示文摘 | Grimpe Christoph Kaiser Ulrich | 2010 | Journal of Management Studies2010，，12： | 1 |
| 14 | Price structure in two-sided markets: Evidence from the magazine industry显示文摘 | Ulrich Kaiser Julian Wright | 2005 | International Journal of Industrial Organization2005，，1： | 1 |
| 15 | Price structure in two- sided markets:Evidence from the magazine industry显示文摘 | ULRICH KAISER JULIAN WRIGHT | 2006 | Int J Industrial Organization2006，，24： | 1 |
| 16 | A Low-Power transponder IC for High-Performance identification systems显示文摘 | ULRICH Kaiser WOLFGANG Steinhagen | 2005 | IEEE Commu Jourl of Solid-State Circuits2005，30，3： | 1 |
| 17 | Price Structure in Two- sided Markets: Evidence from the Magazine Industry 显示文摘 | Wright Julian Ulrich Kaiser | 2006 | Inter- national Journal of Industrial Organization2006，24，1： | 1 |
| 18 | Measuring Knowledge Spillovers in Manufacturing and Services:An Empirical Assessment of Alternative Approaches显示文摘 | Ulrich Kaiser | | 0，，01： | 1 |
| 19 | An empirical test of models explaining research expenditures and research cooperation: evidence for the German service sector显示文摘 | Ulrich Kaiser | 2002 | International Journal of Industrial Organization2002，，6： | 1 |
| 20 | Age-related changes in peripheral blood counts in humans显示文摘 | Ulrich Mahlknecht Simone Kaiser | 2010 | Experimental and Therapeutic Medicine2010，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员