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| 1 | Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis显示文摘AIM To detect the expression of trefoil factors(TFFs)and TWIST1 in colorectal cancer(CRC)and analyze their correlation with metastasis and survival.METHODS This study examined the expression of TFF1,TFF3 and TWIST1 in a total of 75 tumor samples,47 matched normal samples(15 cm from the lesion margin),30metastatic lymph nodes,and 10 liver metastatic cancer samples from patients with CRC.The relationship was then analyzed between the protein expression and different clinical records.TFF1,TFF3,TWIST1,E-cadherin,vimentin andβ-catenin m RNA and protein expression levels were measured in colon cancer cell lines with different metastatic potentials(HIEC,HT29,SW620,and Lo Vo cells),and the correlation of the expression levels with epithelial-mesenchymal transition(EMT)was discussed.RESULTS It was found that 66.7%(50/75),78.7%(59/75)and54.7%(41/75)of tumor tissue samples exhibited positive staining for TFF1,TFF3 and TWIST1 and so did 27.3%(13/47),100%(47/47)and 17%(8/47)of adjacent normal colorectal tissues.Compared with adjacent normal tissues,significant differences were found in the expression of all three proteins in different cancerous tissues(P<0.05).Higher expression of TFF3 and TWIST1 was significantly correlated with lymph node metastasis(P=0.034,P=0.000),advanced stage(P=0.031,P=0.003),and poorer survival(P=0.042 for the TFF3 group,P=0.003for the TWIST1 group).The expression of TFF3 and TWIST1 in cancer cell lines was higher than that in HIEC(a normal human intestinal epithelial cell line)(P<0.05),and the expression intensity demonstrated a tendency to rise with increased metastatic potential both at the protein and m RNA levels.However,TFF1expression demonstrated the opposite tendency.It was also observed that the expression of E-cadherin andβ-catenin tended to decrease while that of vimentin,TWIST1 and Snail tended to rise with the increase in metastatic potential.CONCLUSION The expression of TFF3 and TWIST1 might be associated with the survival of patients with CRC after curative resection and might be pivotal predictors of disease progression.TFF3 may be correlated to the invasiveness of CRC. | Akram Yusup Bailikezi Huji Cheng Fang Fei Wang Tuerxunjiang Dadihan Hai-Jiang Wang Halmurat Upur | 2017 | World Journal of Gastroenterology2017，23，1： | 7 |
| 2 | An magnetic resonance-based plasma metabonomic investigation on abnormal Savda in different complicated diseases显示文摘OBJECTIVE: To provide potential evidence for the existence of abnormal Savda, we assessed host metabonomic responses and dynamic changes occurring in various diseases using1H nuclear magnetic resonance(NMR)-based metabonomics.METHODS: Plasma samples taken from patients with complicated diseases with abnormal Savda(n=140, including 35 cases each of diabetes, asthma,breast cancer, and cervical carcinoma) and from healthy controls(n=35) were analyzed by1H NMR(600 MHz), and the spectral profiles were analyzed by multivariate analysis using orthogonal projection to latent structure with discriminant analysis.RESULTS: Supervised modeling of the data provided very good discrimination between patients and healthy controls. Compared with the healthy controls, the patient groups with different disease conditions displayed similar metabolic changes, characterized by lower creatine, creatinine, lactate, and amino acid levels(including isoleucine, leucine, valine, alanine, and 1-methylhistidine) and higher lipid levels(very low-density lipoproteins and unsaturated lipids). Additionally, cancer patients(breast and cervical) showed decreased myo-inositol,α-glucose, and β-glucose, and increased pyruvate and carnitine in plasma.CONCLUSION:The data indicate that decreased oxidative defense, liver function abnormalities, amino acid deficiencies, and energy metabolism disorders are common characteristics of complicated diseases, which may be related to the formation of abnormal Savda. | Batur Mamtimin Mawlanjan Hizbulla Nazuk Kurbantay Li You Xinghai Yan Halmurat Upur | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 5 |
| 3 | Association of interleukin-6 and C-reactive protein genetic polymorphisms levels with venous thromboembolism显示文摘 | Ailiman Mahemuti Kailibinuer Abudureheman Xiaimuxikamaier Aihemaiti HU Xue-mei XIA Yu-ning TANG Bao-peng Halmurat Upur | 2012 | Chinese Medical Journal2012，，22： | 5 |
| 4 | Chinese and Uighur medicine diagnostic criteria of the evaluation of the Modern drug treatment side-effects in bronchial asthma patients显示文摘We studied Chinese and Uighur medicines and create an automated computer diagnostics system according to principals of Uighur medicine for evaluation of bronchial asthma patient′s state.498 patients with bronchial asthma were enrolled the automated computer diagnostic program.304 patients were evaluated in the process of drug and non-drug treatment.Savda asthma type of Uighur medicine do not corresponds with any of the defined clinico-pathogenetic variants of the disease.Thus,prevailing of atopic bronchial asthma with probability of 0.7 is defined with Savda categories with such as 'Lungs energy deficiency','Spleen energy deficiency' and 'Kidneys Yin deficiency'(P<0.01) variants in Chinese Medicine.The combination of infectious-dependent variant of bronchial asthma Abnormal Savda syndrome with atopy with a probability of 0.8 is accompanied by the categories of 'Hot and Full' asthma with such variants as 'Lungs energy deficiency' 'Spleen energy deficiency','Kidneys Yin deficiency'(P<0.01).Patients with an easier case of Abnormal Savda syndrome bronchial asthma in 71% of cases have prevailing diagnostic categories of 'External,Full and Cold' asthma.Patients with a harder case of Abnormal Savda in 74% of cases belongs to the categories of 'Internal,Empty and Hot' asthma.So,hormone dependency of the disease in 69% of cases is accompanied by the 'Kidneys Yin deficiency' variant and,if there is an aspirin component in the pathogenesis of mixed asthma,in 83% of cases 'Kidneys Yin deficiency' and 'Kidneys Yang deficiency' variants are defined. | Dubrovin Denis Igor Gogol Mikhail Baranov Nurmuhammat Amat Halmurat Upur | 2013 | 新疆医科大学学报2013，36，4： | 2 |
| 5 | Protective effect of Cichorium glandulosum root extract on carbon tetrachloride-induced and galactosamine-induced hepatotoxicity in mice显示文摘 | H. Upur N. Amat B. Bla?ekovi? A. Talip | 2009 | Food and Chemical Toxicology2009，，8： | 1 |
| 6 | Identification of plasma protein markers common to patients with malignant tumour and abnormal Savda in Uighur medicine:a prospective clinical study显示文摘 | Halmurat Upur Yin Chen Mayila Kamilijiang | 2015 | BMC Complement Altern Med2015，15，1： | 1 |
| 7 | Protective effect of Cickorium glandulosum root extract on carbon tetrachloride-induced and galactosamine-induced hepatotoxicity in mice显示文摘 | UPUR H AMAT N BLAZEKOVIC B | 2009 | Food Chem Toxicol2009，，47： | 1 |
| 8 | Cytotoxicity of ab- normal savda munziq aqueous extract in human hepatoma (HepG2) cells显示文摘 | Yusup A Upur H Baudrimont I | 2005 | Fundam Clin Pharmacol2005，19，4： | 1 |
| 9 | The effect of Abnormal Savda Munziq total flavonoids on the proliferation, apoptosis and correlative gene expression in human hepatoma ( HepG2 ) cells显示文摘 | Yusup A Upur H Tursun X | 2006 | Toxicology Letters2006，164，1： | 1 |
| 10 | Cytotoxicity of abnormal savda munziqinhihition of cell growth and DNA protein syn- thesis in HepG2 cells显示文摘 | Yusup A Upur H Baudrimont I | 2004 | Toxicol Appl Pharmacol2004，19，4： | 1 |
| 11 | Plasma metabonomic analysis with ^1H nuclear magnetic resonance revealing the relationship of different tumors and the disease homology theory of traditional uyghur medicine 显示文摘 | Batur Mamtimin Halmurat Upur HAO Fuhua | 2011 | Chinese Journal of Integrative Medicine2011，17，2： | 1 |
| 12 | In vivo hepatoprotective activity of the aqueous extract of Artemisia absinthium L. against chemically and immunologically induced liver injuries in mice显示文摘 | Nurmuhammat Amat Halmurat Upur Biljana Bla?ekovi? | 2010 | Journal of Ethnopharmacology2010，，2： | 1 |
| 13 | Immunomodulatory effects of Abnormal Savda Munsiq, a traditional Uighur medicine, on the combined stress mice显示文摘 | Amat N Upur H Ablimit A | 2009 | J Ethnopharmacol2009，122，1： | 1 |
| 14 | Inhibition of cell growth and cellular protein, DNA and RNA synthesis in hu- man hepatoma (HepG2) cells by ethanol extract of Abnormal Savda Munziq of Traditional Uighur medicine显示文摘 | Upur H Yusup A Baudrimont I | 2011 | Evidence Based Complement Alternat Med2011，，： | 1 |
| 15 | Cytotoxicity of Ab- normal Savda Munziq aqueous extract in human hepatoma (HepG2) cells显示文摘 | Yusup A Upur H Baudrimont I | 2005 | Fundam Clin Pharmaeol2005，19，4： | 1 |
| 16 | Uighur traditional medicine syndrome of abnormal Savda in men is associated with oxidative stress, which can be improved by munziq and mushil of abnormal savda显示文摘 | Upur H A Yusup A Umar A | 2004 | Therapie2004，59，4： | 1 |
| 17 | Effect of Abnormal savda Munziq ethyl acetate extract on the proliferation, apoptosis and correlative gene expression in human hepatoma (HepG2) cells显示文摘 | Yusup A Upur H Kadir T | 2006 | The Journal of China Pharmaceutical University2006，37，2： | 1 |
| 18 | Protective effects of Munziq and Mushii of Abnormal Savda to mitochondrial oxidative damage显示文摘 | Yusup A Upur H Umar A | 2004 | J Fundam Clin Pharmacol2004，18，4： | 1 |
| 19 | Expression of airway mucus-associated proteins in rats with chronic obstructive pulmonary disease with a cold-dryness symptom pattern显示文摘OBJECTIVE: To reveal the effects on expression of airway mucus-associated proteins in rats with chronic obstructive pulmonary disease(COPD) and a cold-dryness symptom pattern induced by elastase and smoking.METHODS: The COPD model was established with an elastase dose into the trachea combined with exposure to smoking; the COPD model cold-dryness symptom pattern was further developed by exposure to a cold, dry environment. After 90 days,pathologic lung sections, inflammatory cytokine levels(measured by enzyme linked immunosorbent assay), m RNA and protein expression of mucus-associated proteins and aquaporins(measured by real-time polymerase chain reaction and western blots) were examined.RESULTS: Cytokines interleukin-6(IL-6), interleukin-8(IL-8), and tumor necrosis factor-α(TNF-α) in the COPD and the cold-dryness symptom pattern COPD groups were all significantly higher than in controls(each P < 0.01). IL-6 and IL-8 levels were higher in the cold-dryness symptom pattern COPD group than in the COPD group(each P < 0.05). The AQP5 m RNA expression in the cold-dryness symptom pattern COPD and COPD groups was lower than in the control group(P < 0.01), and that in the cold-dryness symptom pattern COPD group was lower than the COPD group(P < 0.05). The expression of MUC5 AC and MUC5 B m RNAs in the cold-dryness symptom pattern COPD group and COPD group was higher than in the control group(each P < 0.01), and that in the cold-dryness symptom pattern COPD group was higher than the COPD group(P < 0.01, and P < 0.05, respectively).The ratio of MUC5 AC m RNA/MUC5 B m RNA was COPD group < the cold-dryness symptom pattern COPD group < the control group. AQP4 and AQP5 protein expression in the cold-dryness symptom pattern COPD group was lower than that in the COPD group which was lower again than in the control group. MUC5 AC and MUC5 B expression in the cold-dryness symptom pattern COPD group was higher than in the COPD group and higher again than in the control group.CONCLUSION: Cold-dryness affects the expression of mucus-associated protein m RNA and its corresponding proteins, reducing the secretion of aquaporins and increasing the secretion of mucins. Imbalance in aquaporins and mucins can affect the function of mucus, increasing airway obstruction. | Gao Zhen Halmurat Upur Wang Jing Jing Jing Li Zheng Xu Dan Li Fengsen | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 1 |
| 20 | Abnormal savda munziq, an herbal preparation of traditional Uighur medicine, May prevent 1,2-dimethylhydrazine-Induced rat colon carcinogene- sis显示文摘 | Yusop A Upur H Umar A | 2011 | J Evid Based Complement Alternat Med2011，，15： | 1 |
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