| 1 | 白凡士林(Ph.Eur.)事实上无致敏性(对1992—2004年IVDK试验中80000例患者的资料进行分析,并简要讨论变应原的鉴定)显示文摘Sporadic cases of contact allergy to white petrolatum, which is used as a vehicle in patch test preparations, have been reported. The quantitative relevance of the phenomenon remains yet to be elucidated. Methods: Retrospective analysis of patch test data of the Information Network of Departments of Dermatology (IVDK, http://gffzze646c44f7713477fh6v9pbvf6pn6q6fqo.ffgz.tsg.suse.edu.cn) between 1992 and 2004. Results: Analysis of 79 365 patients patch tested with pure petrolatum yielded 27 ‘ + ’ (0.03% ) and 2 ‘ + + + ’ (0.003% ) reactions. The majority of non-negative reactions (0.3% ) was interpreted as doubtful (235) or mild irritant (32). The negative reaction index (RI) (- 0.8), and the high positivity ratio (PR) (93% ) especially a lack of concordance with patch test preparations containing ≥ 99% petrolatum indicate that many of the ‘ positive’ (+ ) reactions have to be considered as irritant. There were 2 ‘ + + + ’ reactions. In 1 case, an ‘ angry back reaction’ was confirmed. The other case is probably a reading or documentation error, as the majority of patch test reactions to preparations containing petrolatum remained negative in this case also. Conclusions: True allergic patch test reactions to white petrolatum are extremely rare and probably due to an individually increased susceptibility to allergens and/or irritants. This is in agreement with considering petrolatum as a non-sensitizer. | Schnuch A. Lessmann H. Geier J. UterW. 张路坤 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，9： | 0 |
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