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63篇 您的检索式：作者名="Uzui"

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	题名	作者	年代	出处	被引量
1	依普利酮对高糖和IL-1β诱导的心脏成纤维细胞MMP-2表达的影响显示文摘目的探讨依普利酮干预对高糖和白介素1β(IL-1β)诱导的人心脏成纤维细胞基质金属蛋白酶2(MMP-2)表达的影响。方法将人心脏成纤维细胞分别培养在正常葡萄糖浓度(正常对照组)、高浓度葡萄糖(高糖组)和等渗甘露醇(高渗对照组)的培养液中,分别添加IL-1β和(或)盐皮质激素受体阻断剂依普利酮进行干预。明胶酶法测定细胞培养上清液中MMP-2的活性,RT-PCR测定成纤维细胞MMP-2和组织金属蛋白酶抑制因子2(TIMP-2)mRNA的表达。结果与正常对照组比较,高糖组MMP-2活性和mRNA的表达显著增高(P<0.01),高渗对照组MMP-2活性和mRNA表达也增高但低于高糖组(P<0.05)。与高糖组比较,高糖+IL-1β组MMP-2活性和mRNA的表达呈现叠加现象,高糖+依普利酮组和正常对照+IL-1β+依普利酮组MMP-2活性和mRNA的表达分别显著低于高糖组和正常对照+IL-1β组(P<0.05)。结论高糖可通过高渗外的作用诱导人心脏成纤维细胞MMP-2活性增强和mRNA表达增加,IL-1β对该诱导作用具有促进作用,而依普利酮则呈现抑制效应。	池菊芳郭航远唐伟良吕海涛周妍 Hiroyasu UZUI	2012	上海交通大学学报(医学版)2012，32，12：	2
2	The role of protein tyrosine phosphorylation and gelatinase production in the migration and proliferation of smooth muscle cells 显示文摘	Uzui H Lee J D Shimizu H	2000	Atherosclerosis2000，149，1：	1
3	Pravastatin suppresses the increase in matrix metalloproteinase-2 levels after acute myocardial infarction显示文摘	Hiroyasu Uzui Hiromasa Shimizu	2005	Int J Cardiol2005，105，1：	1
4	Pravastatin suppresses the increase in matrix metalloproteinase-2 levels after acute mycardial infarction 显示文摘	Nakaya R Uzui H Shimizu H Naksno A Mitsuke Y Yamazaki T	2005	Intet J Cardio2005，105，1：	1
5	Increased expression of membrane type3 matrix metauoproteinase in human atherosolerotic plaque:role of activated macrophages and inflammatory cytokines显示文摘	Uzui H Harpf A Liu M	2002	Circulation2002，106，：	1
6	Pravastatln suppresses the in- crease in matrix metallo proteinase levels after acute myocardial infarc- tion显示文摘	Nakaya R Uzui H Shimizu H	2005	Int J Cardiol2005，105，1：	1
7	Pravastatin suppresses the increase in matrix metalloproteinase - 2 levels after acute myocardi- al infarction显示文摘	Nakaya R Uzui H Shimizu H	2005	Int J Cardiol2005，105，1：	1
8	Pravastatin suppresses the increase in matalloproteinase-2 levels after acute myocarction显示文摘	Nakay R Uzui H Shimizu H		0，，01：	1
9	Comparative assessment of 18F-fluorodeoxyglucose PET and 99Tcm -tetrofosmin SPECT for the prediction of functional recovery in patients with reperfused acute myocardial infarction显示文摘	Shirasaki H Nakano A Uzui H	2006	Eur J Nuel Med Mol Imaging2006，33，8：	1
10	Effects of magnesium on matrix metalloproteinase-2 production in cultured rat cardiac fibroblasts显示文摘	Yue H Uzui H Lee JD	2004	Basic Res Cardiol2004，99，4：	1
11	Pravastatin suppresses the increase in matrix metalloproteinase-2 levels after acute myocardial infarction显示文摘	Reiko Nakaya Hiroyasu Uzui Hiromasa Shimizu	2005	International Journal of Cardiology2005，105，1：	1
12	Effects of heparin on the production of homocysteine-induced extracellular matrix metalloproteinase-2 in cultured rat vascular smooth muscle cells显示文摘	Guo H Lee J D Uzui H	2007	Can J Cardiol2007，23，4：	1
13	Role of magnesium in hypertensiontherapy显示文摘	Uzui H Lee J D	2005	Clin Calcium2005，15，11：	1
14	Reverse blood flow-glucose metabolism mismatch indicates preserved n-ygen metabolism in pa- tients with revascularised myocardial infarction显示文摘	Fukuoka Y Nakano A Uzui H	2013	Eur J Nucl Med Mol hnaging2013，40，：	1
15	Relationship between microcirculatory dysfunction an resolution of ST - segment elevation in the early phase after primary angioplasty in patient with ST - segment elevation myocardial infarction 显示文摘	Amaya N Nakano A Uzui H	2012	Int J Cardiol2012，159，2：	1
16	Pravastatin suppresses the increase in matrix metalloproteinase-2 levels after acute myocardial infarction 显示文摘	NAKAYA R UZUI H SHIMIZU H	2005	Int J Cardiol2005，105，1：	1
17	The role of protein-tyrosine phosphorylation and gelatinase production in the migration and pmli~rafion of smooth muscle cells显示文摘	Uzui H Lee J D Shimizu H	2000	Atherosclerosis2000，，149：	1
18	Effects of folic acid and magnesium on the production of homocysteine-induced extracellular matrix metal loproteinase-2 in cultured rat vascular smooth muscle cells显示文摘	Guo HY Lee JD Uzui H	2006	Cire J2006，70，1：	1
19	Increased expres- sion of membrane type 3 - matrix metalloproteinase in human atherosclerotic plaque: role of activated macro- phages and inflammatory cytokines 显示文摘	Uzui H Harpf A Liu M	2002	Circulation2002，106，：	1
20	Effects of heparin on the production of homocysteine-induced extracellular matrix metalloproteinase-2 in cultured rat vascular smooth muscle cells显示文摘	Guo H Lee J D Uzui H	2007	Can J Cardiol2007，23，4：	1

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