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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Whole-body MRI for metastases screening:a preliminary study using 3D VIBE sequences with automatic subtraction between noncontrast and contrast enhanced images显示文摘 | Thomson V Pialat JB Gay F | 2008 | Am J Clin Oncol2008，31，3： | 1 |
| 3 | New gene cassettes for trimethoprim resistance, dfr13 ,and Streptomycin-Spectinomytin resistance, aadA4,inserled on a class 1 integron 显示文摘 | ADRIAN P V THOMSON C J KLUGMAN K P | 2000 | Antimicrob Agents Cheroother2000，44，2： | 1 |
| 4 | The Colorado newborn hearing screening project, 1992-1999: on the threshold of effective population-based universal newborn hearing screening显示文摘 | Mehl A L Thomson V | 2002 | Pediatrics2002，109，1： | 1 |
| 5 | Efficiency of bactericides and saprophytic bacteria in reducing colonization and infection of bear flower by Erwinia amylovora 显示文摘 | Thomson S V | 1976 | Phytopathology1976，66，121： | 1 |
| 6 | Whole body MRI for me- tastases screening: a preliminary study using 3D VIBE sequences with automatic subtraction between noncontrast and contrast en- hanced images显示文摘 | Thomson V Pialat J B Gay F | 2008 | Am J Clin Oncol2008，31，3： | 1 |
| 7 | The role of the stigma in fire blight infections 显示文摘 | Thomson S V | 1986 | Phytopathology1986，76，： | 1 |
| 8 | Primate embryonic stem cells显示文摘 | Thomson J A Marshall V S | 1998 | Curt Top Dev Biol1998，，38： | 1 |
| 9 | Magnetic remanence constraints on magnetic inversion models 显示文摘 | Morris B Ugalde H Thomson V | 2007 | The Leading Edge2007，26，8： | 1 |
| 10 | An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors 显示文摘 | Ben-Porath I Thomson M W Carey V J | 2008 | Nat Genet2008，40，5： | 1 |
| 11 | Integrated genomie and pro- teomic analyses of a systematically perturbed metabolic network 显示文摘 | Ideker T Thomson V Ranish JA | 2001 | Science2001，292，5518： | 1 |
| 12 | The vegetative propagation of Pinus radiate:root initiation in cuttings显示文摘 | CAMERON R J THOMSON G V | | 0，，04： | 1 |
| 13 | The Colorado newborn hearing screening project 1992-1999:on the threshold of effective population-based universal newborn hearing screening显示文摘 | MEHL A L THOMSON V | 2002 | Pediatrics2002，109，： | 1 |
| 14 | Factors affecting outcome after percutaneous renal artery stent insertion显示文摘 | Perkovi V Thomson KR Becker GJ | 2002 | J Nephrol2002，15，： | 1 |
| 15 | Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney显示文摘 | Vallon V Thomson SC | 2012 | Ann Rev Physiol2012，74，： | 1 |
| 16 | The Colorado newborn hearing screening project, 1992-1999: on the threshold of effective populationbased universal newborn hearing screening显示文摘 | MEHL A L THOMSON V | 2002 | Pediatrics2002，109，1： | 1 |
| 17 | The roughening of free surface roughness显示文摘 | Thomson P F Shafer B V | 1984 | Adv Technol Plasticity Japan1984，1，： | 1 |
| 18 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 19 | Experiments in autogiro airworthiness for improved handling qualities显示文摘 | THOMSON D G HOUSTON S S SPATHOPOULOS V M | 2005 | Journal of the American Helicopter Society2005，50，4： | 1 |
| 20 | The Colorado newborn hearing screening project, 1992-1999: on the threshold of effective population-based universal newborn hearing screening显示文摘 | Mehl AL Thomson V | 2002 | Pediatrics2002，109，1： | 1 |
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