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	题名	作者	年代	出处	被引量
1	Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages.	Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta	2017	Asian Pacific Journal of Tropical Biomedicine2017，7，3：	3
2	Modified gypsum compounds : An ecologi- cal-economical choice to improve traditional plasters显示文摘	MAGALLANES-RIVERA R X JUAREZ-ALVARADO C A VALDE P	2012	Con- struction and Building Materials2012，37，12：	1
3	Manganese ferrite nanoparticles synthesized through a nanocasting route as a highly active Fenton catalyst显示文摘	Valdés-Solís T Valle-Vigón P álvarez S	2007	Catalysis Communications2007，8，12：	1
4	Non- Frankla actinomycetes isolated from surface-sterilized roots of Casuarina equisetifolia fix nitrogen显示文摘	Valdes M Perez N O Estrada-de Los Santos P	2005	App! Environ Microbiol2005，71，1：	1
5	On the existence of storm-tracks显示文摘	HOSKINS B J VALDES P J	1990	J Atmos Sci1990，47，15：	1
6	Deglacial rapid sea level rises caused by ice-sheet saddle collapses显示文摘	Gregoire L J Payne A J Valdes P J	2012	Nature2012，487，7406：	1
7	A theoretical study of the+ system:Cyanide isocyanide competition and isomerization barrier显示文摘	Redondo P Rayan V Valdes H	2007	Chemical Physics Letters2007，445，：	1
8	On the existence of storm tracks显示文摘	Hoskins B J Valdes P J	1990	Journal of Atmospheric Sciences1990，47，15：	1
9	A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery显示文摘	Vald's P A Leblond F Kim A	2012	Optics Letters2012，37，11：	1
10	Estimation of brain deformation for volumetric image updating in protoporphyrin Ⅸ fluorescence-guided resection显示文摘	Valdes P A Fan X Ji S	2010	Stereotact Funct Neurosurg2010，88，1：	1
11	Maternal plasma-volume expansion and hormonal changes in women with ideopathic fetal growth retardation显示文摘	Salas SP Rosso P Espinoza R Robert JA Valdes G Donoso E	1993	Obstet Gynecol1993，81，：	1
12	Mapping stress-induced changes in autoinducer AI-2 production in chemostat-cultivated Escherichia coli K-12 显示文摘	Delisa M P Valdes J J Bentley W E	2001	J Bacteriol2001，183，9：	1
13	Cooler estimates of Cretaceous temperatures 显示文摘	Sellwood B W Price G D Valdes P J	1994	Nature1994，370，：	1
14	Prediction of modem bauxite occurrence: implications for climate reconstruction显示文摘	Price G D Valdes P J Sellwood B W	1997	Palaeogeography Palaeoclimatology Palaeoecology1997，131，：	1
15	Thyroid hormone administration induces rat liver Nrf2 activation: suppression by N-acetylcysteine pretreatment显示文摘	ROMANQUE P CORNEJO P VALDES S	2011	Thyroid2011，21，6：	1
16	Preregistra- tion study on the safety and contraceptive efficacy of a progester- one-releasing vaginal ring in Chilean nursing women显示文摘	MASSAI R MIRANDA P VALDES P	1999	Contra- ception1999，60，1：	1
17	Effect of drying medium on residual moisture content and viability of freeze-dried Lactic acid bacteria显示文摘	Font de Vald 6 z G de Giori G de Ruiz Holgada A p	1985	Appl Envirom Microbiol1985，49，：	1
18	Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogene- sis显示文摘	Srinivasan K Strickland P Valdes A	2003	Developmental Cell2003，4，：	1
19	Zone based protection for low voltage systems; zone selective interlocking, bus differential and the single processor concept显示文摘	Valdes M Hamer P Papallo T	2008	Pulp and Paper Industry Technical Conference2008，，：	1
20	Experience in management of Fournier's gangrene显示文摘	Villanueva-Saenz E Martinez Hernandez-Magro P Valdes Ovalle M	2002	Tech Coloproctol2002，6，1：	1

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