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| 1 | FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC显示文摘Over recent years,[18F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography(FDG-PET/CT)has proven its role as a staging modality in patients with non-small cell lung cancer(NSCLC).The purpose of this review was to present the evidence to use FDG-PET/CT for response evaluation in patients with NSCLC,treated with epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKI).All published articles from 1November 2003 to 1 November 2013 reporting on 18FFDG-PET response evaluation during EGFR-TKI treatment in patients with NSCLC were collected.In total 7studies,including data of 210 patients were eligible for analyses.Our report shows that FDG-PET/CT responseduring EGFR-TKI therapy has potential in targeted treatment for NSCLC.FDG-PET/CT response is associated with clinical and radiologic response and with survival.Furthermore FDG-PET/CT response monitoring can be performed as early as 1-2 wk after initiation of EGFR-TKI treatment.Patients with substantial decrease of metabolic activity during EGFR-TKI treatment will probably benefit from continued treatment.If metabolic response does not occur within the first weeks of EGFR-TKI treatment,patients may be spared(further)unnecessary toxicity of ineffective treatment.Refining FDG-PET response criteria may help the clinician to decide on continuation or discontinuation of targeted treatment. | Matthijs H van Gool Tjeerd S Aukema Koen J Hartemink Renato A Valdés Olmos Houke M Klomp Harm van Tinteren | 2014 | World Journal of Radiology2014，6，7： | 8 |
| 2 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 3 | Mapping aboveground biomass by integrating geospatial and forest inventory data through a k-nearest neighbor strategy in North Central Mexico显示文摘As climate change negotiations progress,monitoring biomass and carbon stocks is becoming an important part of the current forest research.Therefore,national governments are interested in developing forest-monitoring strategies using geospatial technology.Among statistical methods for mapping biomass,there is a nonparametric approach called k-nearest neighbor(kNN).We compared four variations of distance metrics of the kNN for the spatially-explicit estimation of aboveground biomass in a portion of the Mexican north border of the intertropical zone.Satellite derived,climatic,and topographic predictor variables were combined with the Mexican National Forest Inventory(NFI)data to accomplish the purpose.Performance of distance metrics applied into the kNN algorithm was evaluated using a cross validation leave-one-out technique.The results indicate that the Most Similar Neighbor(MSN)approach maximizes the correlation between predictor and response variables(r=0.9).Our results are in agreement with those reported in the literature.These findings confirm the predictive potential of the MSN approach for mapping forest variables at pixel level under the policy of Reducing Emission from Deforestation and Forest Degradation(REDD+). | Carlos A AGUIRRE-SALADO Eduardo J TREVIO-GARZA Oscar A AGUIRRE-CALDERóN Javier JIMNEZ-PREZ Marco A GONZLEZ-TAGLE José R VALDZ-LAZALDE Guillermo SNCHEZ-DíAZ Reija HAAPANEN Alejandro I AGUIRRE-SALADO Liliana MIRANDA-ARAGóN | 2014 | Journal of Arid Land2014，6，1： | 3 |
| 4 | ECG after near-drowning mimicking acute coronary syndrome with left main coronary artery involvement显示文摘We present the case of a 74-year-old man with diabetes and hypertension who had to be rescued owing to a near-drowning syndrome at sea.When he was rescued,he complained of dyspnea and chest pain.An electrocardiogram(ECG)suggested acute coronary syndrome(ACS)affecting the left main coronary artery.Therefore,he was referred to our hospital for urgent coronary angiography. | Alfredo Vidal García Javier Lacunza Ruiz José María Lpez Ayala Mariano Valdés | 2013 | World Journal of Emergency Medicine2013，4，1： | 2 |
| 5 | Making drug discovery a SNP显示文摘 | Campbell DA Valdes A Spurr N | 2000 | Drug Discov Today2000，5，： | 1 |
| 6 | First report on fatal myocar- ditis associated with adenovirus infection in Cuba 显示文摘 | Valdes O Acosta B Pinon A | 2008 | J Med Virol2008，80，10： | 1 |
| 7 | Modified gypsum compounds : An ecologi- cal-economical choice to improve traditional plasters显示文摘 | MAGALLANES-RIVERA R X JUAREZ-ALVARADO C A VALDE P | 2012 | Con- struction and Building Materials2012，37，12： | 1 |
| 8 | Kinetics and Mechanism of Low - temperature SCR of NO with NH, Over Vanadium Oxide Supported on Carbon - ceramic Cellular Monoliths 显示文摘 | Valdes - Solis T Marban G Fuertes A B | 2004 | Ind EngChem Res2004，43，10： | 1 |
| 9 | Heterogeneous and homogeneous catalytic ozonation of benzothiazole promoted by activated cabon:Kinetic approach显示文摘 | Héctor Valdés Zaror C A | 2006 | Chemosphere2006，65，7： | 1 |
| 10 | Corporate governance, ownership structure and performance in Mexico显示文摘 | Martin-Reyna J M S Durim-Vezquez R Valdes A L | 2012 | International Business Research2012，5，： | 1 |
| 11 | Diagnosing tuberculous pleu- ral effusion using clinical data and pleural fluid analysis:A study of patients less than 40 years - old in an area with a high incidence of tuberculosis显示文摘 | Valdes L San Jose ME Pose A | 2010 | Respir Med2010，104，8： | 1 |
| 12 | Deglacial rapid sea level rises caused by ice-sheet saddle collapses显示文摘 | Gregoire L J Payne A J Valdes P J | 2012 | Nature2012，487，7406： | 1 |
| 13 | Obesity, cigarette smoking, and telomere length in women显示文摘 | AM Valdes T Andrew JP Gardner M Kimura E Oelsner LF Cherkas A Aviv TD Spector | 2005 | The Lancet2005，，9486： | 1 |
| 14 | Global warming and hydrological cycle 显示文摘 | Loaiciga H A Valdes J B Vogel R | 1996 | Journal of Hydrology1996，174，： | 1 |
| 15 | Allele frequencies at microsatellite loci: the stepwise mutation model revisited显示文摘 | Valdes A M | 1993 | Genetics1993，133，3： | 1 |
| 16 | Low-tem- perature SCR of NOx with NH3 over carbon-ceramic supported catalysts显示文摘 | VALDES SOLIS T MARB N G FUERTES A B | 2003 | Applied Catalysis B~ Environmental2003，46，2： | 1 |
| 17 | Mutation processes of simple-sequence repeat loci in human population显示文摘 | DI RIENZO A PETERSON A C GARZA J C VALDES A M SLATKIN M FREIMER N B | 1994 | Proceedings of the National Academy of Sciences USA1994，91，： | 1 |
| 18 | A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery显示文摘 | Vald's P A Leblond F Kim A | 2012 | Optics Letters2012，37，11： | 1 |
| 19 | Allele frequencies at microsatellite loci: the stepwise mutation model revisited显示文摘 | Valdes A M Slatkin M Freimer N B | 1993 | Genetics1993，133，： | 1 |
| 20 | Assessment of pregestational insulin resistance as a risk factor of pree- clampsia显示文摘 | Valdes E Sepulveda-Marttnez A Manukian B | 2014 | GynecolObstet Invest2014，77，2： | 1 |
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