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| 1 | Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma显示文摘Chronic hepatitis B virus(HBV) infected patients have an almost 100-fold increased risk to develop hepatocellular carcinoma(HCC). HCC is the fifth most common and third most deadly cancer worldwide. Up to 50% of newly diagnosed HCC cases are attributed to HBV infection. Early detection improves survival and can be achieved through regular screening. Six-monthly abdominal ultrasound, either alone or in combination with alphafetoprotein serum levels, has been widely endorsed for this purpose. Both techniques however yield limited diagnostic accuracy, which is not improved when they are combined. Alternative circulating or histological markers to predict or diagnose HCC are therefore urgently needed. Recent advances in systems biology technologies have enabled the identification of several new putative circulating biomarkers. Although results from studies assessing combinations of these biomarkers are promising, evidence for their clinical utility remains low. In addition, most of the studies conducted so far show limitations in design. Attention must be paid for instance to different ethnicities and different etiologies when studying biomarkers for hepatocellular carcinoma. This review provides an overview on the current understandings and recent progress in the field of diagnostic and predictive circulating biomarkers for hepatocellular carcinoma in chronically infected HBV patients and discusses the future prospects. | Stijn Van Hees Peter Michielsen Thomas Vanwolleghem | 2016 | World Journal of Gastroenterology2016，22，37： | 13 |
| 2 | Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers显示文摘Here, we describe the use of monolayers of intestinal epithelial cells derived from intestinal organoids and transcriptomics to investigate the direct effects of dietary protein sources on epithelial function. Mechanically dissociated 3 D organoids of mouse duodenum were used to generate a polarized epithelium containing all cell types found in the tissue of origin. The organoid-derived cell monolayers were exposed to 4%(w/v) of ‘undigested(non-hydrolysed)-soluble' fraction of protein sources used as feed ingredients [soybean meal(SBM) and casein], or alternative protein sources(spray dried plasma protein, and yellow meal worm), or controls for 6 h prior to RNA isolation and transcriptomics. All protein sources altered expression of unique biological processes in the epithelial cells. Exposure of intestinal organoids to SBM downregulated expression of retinol and retinoid metabolic processes as well as cholesterol and lipid biosynthetic pathways, consistent with the reported hypotriglyceridaemic effect of soy protein in vivo. These findings support the use of intestinal organoids as models to evaluate complex interactions between dietary ingredients and the intestinal epithelium and highlights some unique host effects of alternative protein sources in animal feed and potentially human food. | Soumya K.Kar Bart van der Hee Linda M.P.Loonen Nico Taverne Johanna J.Taverne-Thiele Dirkjan Schokker Mari A.Smits Alfons J.M.Jansman Jerry M.Wells | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 3 |
| 3 | GC-MS analysis of breath odor compounds in liver patients显示文摘 | Van den Velde S Nevens F Van Hee P | 2008 | J Chromatogr B Analyt Technol Biomed Life Sci2008，875，2： | 1 |
| 4 | Multistage electrodialysis for large-scale separation of raeemie mixtures显示文摘 | Van der Ent EM Van Hee P Keurentjes JTF | 2002 | J Membr Sei2002，204，12： | 1 |
| 5 | Biodegradation of low molecular weight organic acids in coniferous forest Podzolic soil显示文摘 | VAN HEES P A W JONES D L GODBOLD D L | 2002 | Soil Biology &Biochemistry2002，34，： | 1 |
| 6 | The carbon we do not see-the impact of low molecular weight compounds on carbon dynamics and respiration in forest soils: a review显示文摘 | VAN HEES P A W JONES D L FINLAY R | 2005 | Soil Biology : Biochemistry2005，37，1： | 1 |
| 7 | Low molecular weight organic acids adsorption in forest soils: effects on soil solution concentrations and biodegradation rates显示文摘 | VAN HEES P A W VINOGRADOFF S I EDWARDS A C | 2003 | Soil Biology & Biochemistry2003，35，： | 1 |
| 8 | Capabilities and Achievements:An Empirical Study显示文摘 | Anand Paul Martin van Hees | 2006 | Journal of Socio-Economics2006，，2： | 1 |
| 9 | Deep venous thrombosis after laparoscopic cholecystectomy and prevention with nadroparin 显示文摘 | Schaepkens Van Riempst J T Van Hee R H Weyler J J | 2002 | Surg Endosc2002，16，1： | 1 |
| 10 | Business process redesign: a Petri-net-based approach显示文摘 | van der Aalst W van Hee K M | 1996 | Computers in Industry1996，29，12： | 1 |
| 11 | Gravity Survey of the North Sea 显示文摘 | Van Hees G L | 1983 | Marine Geodesy1983，6，2： | 1 |
| 12 | Business Process Redesign:A Petri-net-based Approach 显示文摘 | Van Der Aalst W M P Van Hee K M | 1996 | Computers in Industry1996，29，12： | 1 |
| 13 | Value of somatosensory and motor evoked potentials in predicting arm reeovmw after a stroke显示文摘 | Feys H Van Hees J Bruvninekx F | 2000 | J Neural Neurosurg Psychiatry2000，68，： | 1 |
| 14 | Deep venous thrombosis after laparoscopic cholecystectomy and prevention with nadroparin 显示文摘 | Schaepkens Van Riempst JT Van Hee RH | 2002 | Surg Endosc2002，16，1： | 1 |
| 15 | Thaumasite swelling in historic mortars: field observations and laboratory research显示文摘 | van HEES R P J WIJFFELS T J van der KLUGT L J A R | 2003 | Cem & Concr Compo2003，25，8： | 1 |
| 16 | Predictors of mortality af- ter aortic valve replacement显示文摘 | Tjang Y S van Hees Y Korfer R | 2007 | EurJ Cardiothorac Sury2007，32，3： | 1 |
| 17 | Desalination of masom structures: Fine tuning of pore size distribution of poul- tices to substrate properties 显示文摘 | LUBELLI B VAN HEES R | 2010 | Journal of Cultural Herit- age2010，11，1： | 1 |
| 18 | Precision of the Geoid, Computed from Terrestrial Gravity Measurements显示文摘 | STRANG VAN HEES G | 1986 | Manuscripta Geodaetica1986，11，： | 1 |
| 19 | Multistage electrodialysis for large - scale separation of racemic mixtures显示文摘 | E M van der Ent P van Hee Keurentjes J T F | 2002 | J Membr Sci2002，204，： | 1 |
| 20 | Plant-induced changes in soil chemistry do not explain differences in uranium transfer显示文摘 | L. Duquène H. Vandenhove F. Tack E. Van der Avoort M. Van Hees J. Wannijn | 2006 | Journal of Environmental Radioactivity2006，，1： | 1 |
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