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| 1 | Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease:A controversial issue显示文摘Autophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to macronutrients.The potential role of autophagy in disease is increasingly recognised and investigated in the last decade.Nowadays it is commonly accepted that autophagy plays a role in the hepatic lipid metabolism.Hence,dysfunction of autophagy may be an underlying cause of non-alcoholic fatty liver disease.However,controversy of the exact role of autophagy in the lipid metabolism exists:some publications report a lipolytic function of autophagy,whereas others claim a lipogenic function.This review aims to give an update of the present knowledge on autophagy in the hepatic lipid metabolism,hepatic insulin resistance,steatohepatitis and hepatic fibrogenesis. | Wilhelmus J Kwanten Wim Martinet Peter P Michielsen Sven M Francque | 2014 | World Journal of Gastroenterology2014，20，23： | 17 |
| 2 | Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma显示文摘Chronic hepatitis B virus(HBV) infected patients have an almost 100-fold increased risk to develop hepatocellular carcinoma(HCC). HCC is the fifth most common and third most deadly cancer worldwide. Up to 50% of newly diagnosed HCC cases are attributed to HBV infection. Early detection improves survival and can be achieved through regular screening. Six-monthly abdominal ultrasound, either alone or in combination with alphafetoprotein serum levels, has been widely endorsed for this purpose. Both techniques however yield limited diagnostic accuracy, which is not improved when they are combined. Alternative circulating or histological markers to predict or diagnose HCC are therefore urgently needed. Recent advances in systems biology technologies have enabled the identification of several new putative circulating biomarkers. Although results from studies assessing combinations of these biomarkers are promising, evidence for their clinical utility remains low. In addition, most of the studies conducted so far show limitations in design. Attention must be paid for instance to different ethnicities and different etiologies when studying biomarkers for hepatocellular carcinoma. This review provides an overview on the current understandings and recent progress in the field of diagnostic and predictive circulating biomarkers for hepatocellular carcinoma in chronically infected HBV patients and discusses the future prospects. | Stijn Van Hees Peter Michielsen Thomas Vanwolleghem | 2016 | World Journal of Gastroenterology2016，22，37： | 13 |
| 3 | Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks显示文摘AIM: To study the predictive value of the vegetative- depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-2b of chronic hepatitis C (CHC) patients. METHODS: The predictive value of vegetative- depressive symptoms at 4 wk of treatment for the occurrence of a subsequent diagnosis of major depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multi- center treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS: Out of 49 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION: In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetativedepressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results. | Geert Robaeys Jozef De Bie Marieke C Wichers Liesbeth Bruckers Frederik Nevens Peter Michielsen Marc Van Ranst Frank Buntinx | 2007 | World Journal of Gastroenterology2007，13，43： | 4 |
| 4 | HBV-specific lymphoproliferative and cytokine responses in patients with chronic hepatitis B显示文摘 | Johan Vingerhoets Peter Michielsen Guido Vanham Eugène Bosmans Wilma Paulij Albert Ramon Paul Pelckmans Luc Kestens Geert Leroux-Roels | 1998 | Journal of Hepatology1998，，1： | 1 |
| 5 | HLA association of amoxicillin-clavulanate–induced hepatitis显示文摘 | Marc L. Hautekeete Yves Horsmans Christine van Waeyenberge Christian Demanet Jean Henrion Louis Verbist Reginald Brenard Christine Sempoux Peter P. Michielsen Paul S.H. Yap Jacques Rahier Andre P. Geubel | 1999 | Gastroenterology1999，，5： | 1 |
| 6 | Diagnostic challenges in alcohol use disorder and alcoholic liver disease显示文摘Alcohol use disorders represent a heterogeneous spectrum of clinical manifestations that have been defined by the Diagnostic and Statistical Manual of Mental Disorders-5. Excessive alcohol intake can lead to damage of various organs, including the liver. Alcoholic liver disease includes different injuries ranging from steatosis to cirrhosis and implicates a diagnostic assessment of the liver disease and of its possible complications. There is growing interest in the possible different tools for assessing previous alcohol consumption and for establishing the severity of liver injury, especially by noninvasive methods. | Luisa Vonghia Peter Michielsen Geert Dom Sven Francque | 2014 | World Journal of Gastroenterology2014，20，25： | 1 |
| 7 | Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis显示文摘 | An Verrijken Sven Francque Ilse Mertens Janne Prawitt Sandrine Caron Guy Hubens Eric Marck Bart Staels Peter Michielsen Luc Van Gaal | 2014 | Hepatology2014，，1： | 1 |
| 8 | Hepatitis B virus and hepatitis C virus infections in Belgium: similarities and differences in epidemics and initial management显示文摘 | Bénédicte De Vroey Christophe Moreno Wim Laleman Marc van Gossum Isabelle Colle Chantal de Galocsy Philippe Langlet Geert Robaeys Hans Orlent Peter Michielsen Jean Delwaide Hendrik Reynaert Fran?ois D’Heygere Dirk Sprengers Stefan Bourgeois Collins Assene | 2013 | European Journal of Gastroenterology & Hepatology2013，，5： | 1 |
| 9 | Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis显示文摘 | Sven Francque An Verrijken Ilse Mertens Guy Hubens Eric Van Marck Paul Pelckmans Luc Van Gaal Peter Michielsen | 2010 | European Journal of Gastroenterology & Hepatology2010，，12： | 1 |
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