|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 3 | Benign par-oxymal vertigo horizontal canal 显示文摘 | PAGNIN P NUTI D VANNUCCI P | 1989 | ORL1989，51，： | 1 |
| 4 | The treatment of horizontal canal positional vertigo :our experience in 66 cases 显示文摘 | CASANI A P VANNUCCI G FATTOR1 B | 2002 | Laryngoscope2002，112，： | 1 |
| 5 | Wavelet change-point prediction of transmembrane proteins显示文摘 | Lio P Vannucci M | 2000 | Bioinformatics2000，16，： | 1 |
| 6 | Fluorescent labelledthiourea-bridged glycodendrons 显示文摘 | Krist P Vannucci L Kuzma M | 2004 | Chembiochem2004，5，4： | 1 |
| 7 | The location and sizing of historical earthquakes using the attenuation of macroseismic intensity with distance显示文摘 | Gasperini P Vannucci G Tripone D etal | 2010 | Bull Seismol Soc Am2010，100，： | 1 |
| 8 | Microwave applicator for hy- perthermia treatment on in vivo melanoma model 显示文摘 | Togni P Vrba J Vannucci L | 2010 | Med Biol Eng Comput2010，48，： | 1 |
| 9 | The treatment of horizontal canal positional vertigo :our experience in 66 cases 显示文摘 | CASANI A P VANNUCCI G FATTOR1 B | 2002 | Laryngoscope2002，112，： | 1 |
| 10 | Some exact solutions for fully orthotropic laminates 显示文摘 | Valot E Vannucci P | 2005 | Composite Structures2005，69，2： | 1 |
| 11 | Fractionation of Nb and Ta from Zr and Hf at mantle depths: The role of titanian pargasite and kaersutite 显示文摘 | Tiepolo M Bottazzi P Foley S F Oberti R Vannucci R Zanetti A | 2001 | J Petrol2001，42，1： | 1 |
| 12 | The treatment of horizontal canal positional vertigo:our experience in 66cases显示文摘 | CASANI A P VANNUCCI G FATTORI B | 2002 | Laryngoscope2002，112，： | 1 |
| 13 | Immunostimulatory properties and antitumor activities of glucans (Review) 显示文摘 | Vannucci L Krizan J Sima P | 2013 | Int J Oncol2013，43，2： | 1 |
| 14 | Assessment of sleep apnea syndrome in treated acromegalic patients and correlation of its severity with clinical and laboratory parameters 显示文摘 | Vannucci L Luciani P Gagliardi E | 2013 | J Endocrinol Invest2013，36，4： | 1 |
| 15 | The treatment of horizontal canal positional vertigo: our experience in 66 cases显示文摘 | CASANI A P VANNUCCI G FATTORI B | 2002 | Laryngoscope2002，112，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员