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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression显示文摘 | Vargas AC Reed AE Waddell N | 2012 | Breast Cancer Res Treatm2012，135，1： | 1 |
| 4 | Tumor microR-NA expression profiling identifies circulating microRNAs for earlybreast cancer detection显示文摘 | Matamala N Vargas MT Gonzalez - Campora R | 2015 | Clin Chem2015，61，8： | 1 |
| 5 | Esters of 3-chlOro-1,2- propanediol (3-MCPD) in vegetable oils: significance in the formation of 3-MCPD显示文摘 | SEEFELDER W VARGA N STUDER A | 2008 | Food Additives and Contaminants2008，25，4： | 1 |
| 6 | Acrylamide from Maillard reaction products显示文摘 | Stadler R H Blank I Varga N | 2002 | Nature2002，419，： | 1 |
| 7 | Conservative management of cesarean scar pregnancy with sonographically guided transwaginal methotrexate injection显示文摘 | Brasic N Warden M Vargas JE | 2013 | J Ultrasound Med2013，32，： | 1 |
| 8 | Acrylamide from Maillard reaction products显示文摘 | Stadler R H Blank I Varga N | 2002 | Nature2002，419，6906： | 1 |
| 9 | Bioleaching of refractory gold concentrates at high pulp densities in a nonconventional rotating-drum reactor 显示文摘 | HERRERA M N ESCOBAR B PARRA N GONZALEZ C VARGAS T | 1998 | Minerals and Metallurgy Processing1998，15，： | 1 |
| 10 | Hyperbranched polyglycerol electrospun nanofibers for wound dressing applica tions显示文摘 | Vargas E A T Do Vale Baraeho N C De Brilo J | 2010 | Aeta biornaterialia2010，6，3： | 1 |
| 11 | Esters of 3-ehloro-I , 2- propanediol (3-MCPD) in vegetable oils: significance in the formation of 3-MCPD 显示文摘 | Seefelder W Varga N Studer A | 2008 | Food Additives & Contaminants: Part A Chemistry Analysis Control Exposure & Risk Assessmen2008，25，4： | 1 |
| 12 | Formation of Vinylogous Compounds in Model Maillard Reaction Systems 显示文摘 | Stadler R H Verzegnassi L Varga N | 2003 | Chemical Research in Toxicology2003，16，： | 1 |
| 13 | Acrylamide from maillard reaction products显示文摘 | Stadler R H Blank I Varga N | 2002 | Nature2002，，419： | 1 |
| 14 | The nuclear receptor LXR is a glucose sensor 显示文摘 | Mitro N Mak PA Vargas L | 2007 | Nature2007，445，： | 1 |
| 15 | Triiodothyronine,a regulator of osteoblastic differentiation:depression of histone H4,attenuation of c-fos/ c-jun,and induction of osteocalcin expression显示文摘 | Varga F Rumpler M Luegmayr E Fratzl-Zelman N Glantschnig H Klaushofer K | | 0，，： | 1 |
| 16 | Atherosclerosis of the descending aorta predicts cardiovascular events:A transesophageal echocardiography study显示文摘 | Varga A Gruber N Forster T | 2004 | Cardiovasc Ultrasound2004，2，： | 1 |
| 17 | Acrylamide from maillard ceaction products显示文摘 | STADLE R H BLANK I VARGA N | 2002 | Nature2002，419，： | 1 |
| 18 | Factors associated with local recurrence and cause - specific survival in patients with ductal carcinoma in situ of the breast treated with breast - conserving therapy or mastectomy显示文摘 | Vargas C Kestin L Go N | 2005 | Int J Radiat Oncol Biol Phys2005，63，5： | 1 |
| 19 | Role of the tumor markers CA 199 and carcinoembryonic antigen(CEA)in diagnosis,treatment and prognosis of pancreatic cancer显示文摘 | Kokhanenko N U Ignashov A M Varga E V | 2001 | Vopr Onkol2001，47，3： | 1 |
| 20 | Tri-iodothy-ronine inhibits muhilayer formation of the osteoblastic cell line, MC3T3-E1, by promoting apoptosis 显示文摘 | Varga F Luegmayr E Fratzl-Zelman N | 1999 | J Endocrinol1999，160，1： | 1 |
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