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| 1 | Oocyte Cryopreservation in Human Assited Reproduction显示文摘Embryo cryopreservation(CP) has became a very important part of the clinical use of in vitro fertilization. Oocyte CP offers more advantages compared with embryo freezing with regard to less ethical, legal and moral problems. However, the efficiency of this procedure is still low, which prevents its clinical application in wide range. The aim of our paper is to review the basic principles, technical and safety aspects and current status of oocyte cryopreservation in human assisted reproduction. | J Konc S Cseh E Varga R Kriston K Kanyó | 2006 | Journal of Reproduction and Contraception2006，17，2： | 7 |
| 2 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 3 | Comparison of different lymph node staging systems in prognosis of gastric cancer:a bi-institutional study from Hungary显示文摘Objective: The Union for International Cancer Control(UICC) Node(N) classification is the most common used staging method for the prognosis of gastric cancer. It demands adequate, at least 16 lymph nodes(LNs) to be dissected; therefore different staging systems were invented.Methods: Between March 2005 and March 2010, 164 patients were evaluated at the Department of General Surgery in the Kenézy Gyula Hospital and at the Department of General, Thoracic and Vascular Surgery in the Kaposi Mór Hospital. The 6th, 7th and 8th UICC N-staging systems, the number of examined LNs, the number of harvested negative LNs, the metastatic lymph node ratio(MLR) and the log odds of positive LNs(LODDS) were determined to measure their 5-year survival rates and to compare them to each other.Results: The overall 5-year survival rate for all patients was 55.5% with a median overall survival time of 102 months. The tumor stage, gender, UICC N-stages, MLR and the LODDS were significant prognostic factors for the 5-year survival with univariate analysis. The 6th UICC N-stage did not follow the adequate risk in comparing N2 vs. N0 and N3 vs. N0 with multivariate investigation. Comparison of performances of the residual N classifications proved that the LODDS system was first in the prediction of prognosis during the evaluation of all patients and in cases with less than 16 harvested LNs. The MLR gave the best prognostic prediction when adequate(more than or equal to 16) lymphadenectomy was performed.Conclusions: We suggest the application of LODDS system routinely in western patients and the usage of MLR classification in cases with extended lymphadenectomy. | dezso tóth adrienn bíró zsolt varga miklós torok péterárkosy | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 4 | Decomposition of some polynitro arenes initiated by heat and shock显示文摘 | Róbert Varga Svatopluk Zeman Martin Kouba | 2006 | Journal of Hazardous Materials2006，，3： | 2 |
| 5 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 6 | Activating killer cell immunoglobulin-tike receptor genes' association with recurrent miscarriage显示文摘 | Vargas R G Bompeixe E P Franca P P | 2009 | Am J Reprod Immunol2009，62，1： | 1 |
| 7 | Antioxidant and free radical scavenging activities of 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia 显示文摘 | PF REZ G R M VARGAS S R MARTINEZ M F J | 2004 | Phytother Res2004，18，5： | 1 |
| 8 | Co-occurrence of aflatoxins B1, B2,G1,G2,zearalenone and fumonisin B1 in Brazilian corn显示文摘 | Vargas E A Preis R A Castro L | 2001 | Food Addit Con- tam2001，18，11： | 1 |
| 9 | Ion channels and lymphocyte activation 显示文摘 | PANYI G VARGA Z GASPAR R | 2004 | Immunol Lett2004，92，： | 1 |
| 10 | Predictive control of a three-phase neutral-point-clamped inverter显示文摘 | Vargas R Cortes P Ammarm U | 2007 | IEEE Transactions on Industrial Electronics2007，54，5： | 1 |
| 11 | Tumor microR-NA expression profiling identifies circulating microRNAs for earlybreast cancer detection显示文摘 | Matamala N Vargas MT Gonzalez - Campora R | 2015 | Clin Chem2015，61，8： | 1 |
| 12 | Study of humic-like substances in fog and interstitial aerosol by size-exclusion chromatography and capillary electrophoresis显示文摘 | Z Krivácsy Gy Kiss B Varga I Galambos Zs Sárvári A Gelencsér á Molnár S Fuzzi M.C Facchini S Zappoli A Andracchio T Alsberg H.C Hansson L Persson | 2000 | Atmospheric Environment2000，，25： | 1 |
| 13 | Dollar spot resistance to DMI fungicides显示文摘 | Vargas J M Golembiewski R C Detweiler A R | 1992 | Golf Course Management1992，60，3： | 1 |
| 14 | Juvenile-onset spondyloarthropathies显示文摘 | BURGOS VARGAS R PACHECO TENA C VAZQUEZ MELLADO J | 1997 | Rheum Dis Clin North Am1997，23，3： | 1 |
| 15 | Reduction of humic substances and Fe (Ⅲ ) by hyperthermophilic microorganisms 显示文摘 | LOVLEY D R KASHEFI K VARGAS M | 2000 | Chemical Geology2000，169，9： | 1 |
| 16 | Long-term clinical efficacy of grass-pollen immunotherapy显示文摘 | DURHAM S R WALKER S M VARGA E M | 1999 | N Engl J Med1999，34，1： | 1 |
| 17 | Effects of cationic dopants on the phase transition temperature of titania prepared by the sol-gel method显示文摘 | Vargas S Arroyo R Haro E | 1999 | J Mater Res1999，14，10： | 1 |
| 18 | control of a three-phase neutral-point- inverter 显示文摘 | VARGAS Predictive clamped Electronic R CORTES P AMMANN U | 2007 | IEEE Trans on Industrial s2007，54，5： | 1 |
| 19 | Long-term clinical effeacy of grass-pollen immunotherapy显示文摘 | DURHAM S R WALKER S M VARGA E M | 1999 | N Engl Med1999，341，： | 1 |
| 20 | Magnetization processes in thin magnetic wires 显示文摘 | Varga R Garcia K L Zhukov A | 2006 | Journal of Magnetism & Magnetic Materials2006，300，1： | 1 |
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