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| 1 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 2 | MicroRNA-21 in pancreatic cancer:correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity显示文摘 | Giovannetti E Funel N Peters G J Del Chiaro M Erozenci LA Vasile E | | 0，，： | 1 |
| 3 | Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis显示文摘 | NAGY J A VASILE E FENG D | 2002 | J Exp Med2002，196，11： | 1 |
| 4 | Architecture of a protein central to iron homeostasis: crystal structure and spectroscopic analysis of the ferric uptake regulator显示文摘 | Pohl E Haller J C Mijovilovich A Meyer-Klaucke W Garman E Vasil M L | 2003 | Molecular Microbiology2003，47，4： | 1 |
| 5 | Chemically assisted sputter etching of permalloy using CO or CI2 显示文摘 | VASILE M J MOGAB C J | 1986 | Journal of Vacuum Science & Technology: A1986，4，3： | 1 |
| 6 | Accurate focused ion beam sculpting of silicon using a variable pixel dwell time approach 显示文摘 | ADAMS D P VASILE M J | 2006 | JVac SciTechnolB2006，24，2： | 1 |
| 7 | Hepatic adenomas and focal nodular hyperplasia dynamic CT study显示文摘 | Mathieu D BrunetonJ Drouillard J Pointrean CC and Vasile N | 1986 | Radiology1986，160，1： | 1 |
| 8 | Microfabrication techniques using focused ion beams and emergent applications 显示文摘 | Vasile M J Nassar R Xie J Guo H | 1999 | Micron1999，30，： | 1 |
| 9 | Structures and high and low affinity ligand binding properties of murine type Ⅰ and type Ⅱ macrophage scavenger receptors显示文摘 | Ashkenas J Penman M Vasile E | 1993 | J Lipid Res1993，34，6： | 1 |
| 10 | Convergence analysis and improvements of quantum-behaved particle swarm optimization显示文摘 | Sun J Wu X J Vasile P | 2012 | Information Sciences2012，193，： | 1 |
| 11 | Potential oflaser-induced ablation for future space applications 显示文摘 | Gibbings A Vasile M Hopkins J M | 2012 | Space Policy2012，28，3： | 1 |
| 12 | Focused ion beam technology applied to microstructure fabrication显示文摘 | VASILE M J NASSAR R XIE J | 1998 | Journal of Vacuum Science & Technology B:Microelectronics and Nonometer Structures1998，16，4： | 1 |
| 13 | Micro milling of metal alloys with focused ion beam-fabricated tools显示文摘 | Adams D P Vasile M J Benavides G | 2001 | Precision Engineering2001，25，2： | 1 |
| 14 | Anatomic imaging of abdominal perforator flaps without ionizing radiation:seeing is believing with magnetic resonance imaging angiography显示文摘 | GREENSPUN D VASILE J LEVINE JL | 2010 | J Reconstr Microsurg2010，26，1： | 1 |
| 15 | Intensity-driven- adaptive-neighborhood technique for polarimetrie and interferometric parameter estimation 显示文摘 | Vasile G Trouve E Lee J S | 2006 | IEEE Transactions on Geoseienee and Remote Sensing2006，44，4： | 1 |
| 16 | Microgrooving and Microthreading Tools for Fabricating Curvilinear Features 显示文摘 | Adams D P Vasile M J Krishnan A S M | 2000 | Precision Engineering2000，24，4： | 1 |
| 17 | Expression of Von Wiilebrand factor, an endothelial cell marker, is up - regulated by angiogenesis factors: a potential method for objective assessment of tumor angiogenesis 显示文摘 | ZANETYA L MARCUS S G VASILE J | 2000 | Int J Cancer2000，85，2： | 1 |
| 18 | Anatomic imaging of abdominal perforator flaps without ionizing radiation:seeing is believing with magnetic resonance imaging angiography显示文摘 | Greenspun D Vasile J Levine JL | 2010 | J Reconstr Microsurg2010，26，1： | 1 |
| 19 | Micromilling development and applications for microfabrication 显示文摘 | C R Friedrich P J Coane M J Vasile | 1997 | Microelectronic Engineering1997，，35： | 1 |
| 20 | Intensity-driven Adaptive-neighborhood Technique for Polarimetric and Interferometric SAR Parameters Estimation 显示文摘 | Vasile G Trouve E Lee J S | 2006 | IEEE Trans Geosci Remote Sensing2006，44，6： | 1 |
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