|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 2 | A simple frequency independent method for calculating th reactive and harmonic current in a nonlinear load显示文摘 | Tepper J S Dixon J W Venegas G | 1996 | IEEE Trans on Industrial Electronics1996，43，6： | 1 |
| 3 | A series active power filter based on a sinusoidal current-controlled voltage-source inverter显示文摘 | Dixon J W Venegas G Moran L A | 1997 | IEEE Transactions on Industrial Electronics1997，44，5： | 1 |
| 4 | Cholesterol superlattice modulates CA4P release from liposomes and CA4P cylotoxicity on mammary cancer cells 显示文摘 | Venegas B Zhu W Haloupek NB | 2012 | Biophys J2012，102，9： | 1 |
| 5 | A simple frequency independent method for calculating the reactive and harmonic current in a nonlinear load显示文摘 | Tepper J S Dixon J W Venegas G | 1996 | IEEE Trans Ind Electron1996，43，： | 1 |
| 6 | Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas显示文摘 | Wendell W Tang Arwen A Stelter Samuel French Steven Shen Suimin Qiu Rose Venegas Julie Wen Hui-Qun Wang and Jingwu Xie | 2007 | Modem Pathology(2007)202007，，： | 1 |
| 7 | A Simple Frequency-independent Method for Calculating the Reactive and Harmonic Current in a Nonlinear load显示文摘 | J Sebastian Tepper Juan W Dixon Gustavo Venegas | 1996 | IEEE Transactions on Industrial Electronics1996，43，6： | 1 |
| 8 | Human dermatitis caused by a nymph of Sebekia显示文摘 | Mairena H Solano M Venegas W | 1989 | Am J Trop Med Hvg1989，41，3： | 1 |
| 9 | Evaluation of micronucleus induction in a Chilean population environmentally exposed to arsenic显示文摘 | MARTINEZ V CREUS A VENEGAS W | 2004 | Murat Res2004，564，1： | 1 |
| 10 | A series active power filter based on a sinusoidal current-controlled voltage-source inverter 显示文摘 | DIXON J W VENEGAS G Meran L A | 1997 | IEEE Trans Ind Electron1997，44，： | 1 |
| 11 | A series active power filter based on a sinuseidal current controlled voltage-source inverter显示文摘 | DIXON J W VENEGAS G MORAN L A | 1997 | IEEE Trans on Ind Electron1997，44，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员