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| 1 | Treatment of gastric cancer显示文摘The authors focused on the current surgical treatment of resectable gastric cancer,and significance of periand post-operative chemo or chemoradiation.Gastric cancer is the 4thmost commonly diagnosed cancer and the second leading cause of cancer death worldwide.Surgery remains the only curative therapy,while perioperative and adjuvant chemotherapy,as well as chemoradiation,can improve outcome of resectable gastric cancer with extended lymph node dissection.More than half of radically resected gastric cancer patients relapse locally or with distant metastases,or receive the diagnosis of gastric cancer when tumor is disseminated;therefore,median survival rarely exceeds12 mo,and 5-years survival is less than 10%.Cisplatin and fluoropyrimidine-based chemotherapy,with addition of trastuzumab in human epidermal growth factor receptor 2 positive patients,is the widely used treatment in stageⅣpatients fit for chemotherapy.Recent evidence supports the use of second-line chemotherapy after progression in patients with good performance | Michele Orditura Gennaro Galizia Vincenzo Sforza Valentina Gambardella Alessio Fabozzi Maria Maddalena Laterza Francesca Andreozzi Jole Ventriglia Beatrice Savastano Andrea Mabilia Eva Lieto Fortunato Ciardiello Ferdinando De Vita | 2014 | World Journal of Gastroenterology2014，20，7： | 116 |
| 2 | Clinical management of advanced gastric cancer: The role of new molecular drugs显示文摘Gastric cancer is the fourth most common malignant neoplasm and the second leading cause of death for cancer in Western countries with more than 20000 new cases yearly diagnosed in the United States.Surgery represents the main approach for this disease but,notwithstanding the advances in surgical techniques,we observed a minimal improvement in terms of overall survival with a significant increasing of relapsing disease rates.Despite the development of new drugs has significantly improved the effectiveness of chemothera-py,the prognosis of patients with unresectable or metastatic gastric adenocarcinoma remains poor.Recently,several molecular target agents have been investigated;in particular,trastuzumab represents the first target molecule showing improvements in overall survival in human epithelial growth factor 2-positive gastric cancer patients.New molecules targeting vascular epithelial growth factor,mammalian target of rapamycin,and anti hepatocyte growth factor-c-Met pathway are also under investigation,with interesting results.Anyway,it seems necessary to select more accurately the population to treat with new agents by the identification of new biomarkers in order to optimize the results.In this paper we review the actual'scenario'of targeted treatments,also focusing on the new agents in development for gastric cancer and gastro-esophageal carcinoma,discussing their efficacy and potential applications in clinical practice. | Ferdinando De Vita Natale Di Martino Alessio Fabozzi Maria Maddalena Laterza Jole Ventriglia Beatrice Savastano Angelica Petrillo Valentina Gambardella Vincenzo Sforza Luigi Marano Annamaria Auricchio Gennaro Galizia Fortunato Ciardiello Michele Orditura | 2014 | World Journal of Gastroenterology2014，20，40： | 12 |
| 3 | Congenital malformations and asymmetric crying facies 显示文摘 | Garzena E Ventriglia A Patanella GA | 2000 | Acta Biomed Ateneo Parmense2000，71，： | 1 |
| 4 | Osteoclast stimulating and differentiating factors in human cholesteatoma显示文摘 | Hamzei M Ventriglia G Hagnia M | 2003 | Laryngoscope2003，113，： | 1 |
| 5 | VEGF serum levels in depressed patients during SSRI antidepressant treatment显示文摘 | Ventriglia M Zanardini R Pedrini L | 2009 | Prog Neuropsychopharmacol Biol Psychiatry2009，33，1： | 1 |
| 6 | Simplified clean-up for the determination of benzimidazolic fungicides by high-performance liquid chromatography with UV detection显示文摘 | A D MUCCIO I CAMONI M VENTRIGLIA | 1995 | 1995，，1： | 1 |
| 7 | Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients 显示文摘 | Zanardini R Gazzoli A Ventriglia M | 2006 | J Affect Disord2006，91，1： | 1 |
| 8 | 3' UTR (AGG)n repeat of glial eell line-derived neurotrophic factor (GDNF) gene polymorphism in schizophrenia显示文摘 | Michelato A Bonvicini C Ventriglia M | 2004 | Neurosci Lett2004，357，3： | 1 |
| 9 | 3' UTR(AGG) n repeat of ghal cell line-derived neurotrophic factor(GDNF) gene polymorphism in schizophrenia 显示文摘 | Michelato A Bonvicini C Ventriglia M | 2004 | Neurosci Lett2004，357，3： | 1 |
| 10 | Simplified cleanup for the determination of benzimidazolic fungicides by highperformance liquid chromatography with UV detection显示文摘 | MUCCIO A DI COMONI I VENTRIGLIA M | 1995 | Journal of Chromatography A1995，697，： | 1 |
| 11 | Congenital malformations and asymmetric crying facies显示文摘 | Garzena E Ventriglia A Patanella GA | 2000 | Acta Biomed Ateneo Parmense2000，71，： | 1 |
| 12 | Effects of he- mochromatosis and transferrin gene mutations on peripheral iron dyshomeostasis in mild cognitive impairment and AI- zheimer's and Parkinson's diseases显示文摘 | Mariani S Ventriglia M Simonelli I | 2013 | Front Aging Neuro- sci2013，，5： | 1 |
| 13 | VEGF serum levels in depressed patients during SSRI antidepressant treatment 显示文摘 | Ventriglia M Zanardini R Pedrini L | 2009 | Frog Neuropsychopharmacol Biol Psychiatry2009，33，： | 1 |
| 14 | 'Free' copper in serum of Alzheimer's disease patients correlates with markers of liver function显示文摘 | Squitti R Ventriglia M Barbati G | 2007 | J Neural Transm2007，114，12： | 1 |
| 15 | Effect of repetitive tranranial manetic stimulation on semm brain derived neurotmphic factor in drug resistant depressed patients显示文摘 | Zanardini R Gazzoli A Ventriglia M | 2006 | J Affect Disord2006，91，： | 1 |
| 16 | Osteoclast stimulating and differentiating factors in human cholesteatoma显示文摘 | Hamzei M Ventriglia G Hagnia M | 2003 | Laryngoscope2003，113，3： | 1 |
| 17 | MRI features of solid pseudopapillary neoplasm of the pancreas显示文摘 | Ventriglia A Manfredi R Mehrabi S | 2014 | Abdom Imaging2014，39，6： | 1 |
| 18 | Congenital malformations and asymmetric crying facies 显示文摘 | Garzena E Ventriglia A Patanclla GA Simonitti A Becchino L Garbarini S | 2000 | Acta Biomed Ateneo Parmense2000，71，1： | 1 |
| 19 | Association between sex,systemic iron variation and probability of Parkinson′s disease显示文摘 | Mariani S Ventriglia M Simonelli I | 2016 | Int J Neurosci2016，126，4： | 1 |
| 20 | Copper in Alzheimer's disease:a meta-analysis of serum,plasma,and cerebrospinal fluid studies显示文摘 | Bucossi S Ventriglia M Panetta V | 2011 | J Alzheimers Dis2011，24，1： | 1 |
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